{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:18:48Z","timestamp":1792603128225,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Familial multiple lipomatosis (FML) is a rare hereditary disease characterized by multiple subcutaneous lipomas, most commonly affecting the trunk and extremities. Although benign, the cumulative tumour burden can cause cosmetic disfigurement, discomfort and functional limitations. Treatment options include conventional excision, liposuction and injection lipolysis, but there are no consensus guidelines, and evidence remains fragmented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To summarize reported management strategies, outcomes and recurrence rates to better inform clinical decision-making for the management of FML.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted in accordance with PRISMA guidelines using OVID Medline (1946\u2013April 2025) and Embase (1974\u2013April 2025). Of 4259 studies identified, 15 case reports met the inclusion criteria. Data were extracted on demographics, lesion distribution, management and recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patient ages ranged from 14 to 71\u2005years, with a male predominance and strong familial clustering. Lesions were typically soft, mobile and nontender, most often located on the arms, thighs and trunk. Excision was the primary treatment in most reports (n = 12), followed by liposuction (n = 2) and injection lipolysis (n = 1). Recurrence occurred with both excision and injection treatments, although follow-up data were inconsistently reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Minimally invasive excision and liposuction-based approaches show promise for improved cosmesis. However, their interpretation in the current literature remains limited by the lack of comparative or prospective studies, substantial heterogeneity among studies and the lack of standardized outcomes. This review consolidates the existing literature on FML, underscoring the need for further studies with patient-reported outcome measures to clarify recurrence risk and optimize management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llag252","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:39:53Z","timestamp":1781613593000},"source":"Crossref","is-referenced-by-count":1,"title":["Treatment of familial multiple lipomatosis: a systematic review"],"prefix":"10.1093","author":[{"given":"Kieron","family":"Young","sequence":"first","affiliation":[{"name":"Imperial College London , South Kensington, London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dardan","family":"Popova","sequence":"additional","affiliation":[{"name":"The Royal London Hospital, Barts Health NHS Trust , London 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