{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:19:52Z","timestamp":1788434392565,"version":"build-2803163510"},"reference-count":9,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Skin toxicities like paronychia and acneiform rash are common side effects of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) and significantly impact patients\u2019 quality of life. Tetracycline antibiotics are the recommended first-line treatment but can cause side effects, leading to intolerance and untreated toxicities, highlighting the need for alternative therapies. We present a case of stage IV EGFR-mutated non-small cell lung cancer treated with the second-generation EGFR TKI, dacomitinib. The patient developed grade 3 skin toxicities and was subsequently treated with azithromycin after demonstrating intolerance to tetracycline antibiotics. Azithromycin was administered using various dosing strategies, and we found 500\u2005mg every other day to be the most effective regimen for treating EGFR TKI-induced acneiform rash. However, this approach appeared to be less effective in managing paronychia.<\/jats:p>","DOI":"10.1093\/ced\/llag346","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:44:01Z","timestamp":1785498241000},"source":"Crossref","is-referenced-by-count":0,"title":["Pulsed azithromycin for the treatment of dacomitinib-induced skin toxicity in a patient with tetracycline intolerance: a case report"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4996-1978","authenticated-orcid":false,"given":"Wei","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Pharmacy, National Taiwan University Cancer Center , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Taiwan University Cancer Center , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-3729","authenticated-orcid":false,"given":"Mong-Wei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Surgery, National Taiwan University Hospital , Taipei ,","place":["Taiwan"]},{"name":"National Taiwan University College of Medicine , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qing","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Nursing, National Taiwan University Cancer Center , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yu","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-0850","authenticated-orcid":false,"given":"Shu-Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National Taiwan University Cancer Center , Taipei ,","place":["Taiwan"]},{"name":"School of Pharmacy, College of Medicine, National Taiwan University , Taipei ,","place":["Taiwan"]},{"name":"Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"key":"2026090306520096400_llag346-B1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev-med-051718-013524","article-title":"Precision management of advanced non-small cell lung cancer","volume":"71","author":"Yang","year":"2020","journal-title":"Annu Rev 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inhibitor-induced skin rashes: results of a placebo-controlled trial from the North Central Cancer Treatment Group (N03CB)","volume":"113","author":"Jatoi","year":"2008","journal-title":"Cancer"},{"key":"2026090306520096400_llag346-B5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000338865","article-title":"Azithromycin pulses for the treatment of epidermal growth factor receptor inhibitor-related papulopustular eruption: an effective and convenient alternative to tetracyclines","volume":"224","author":"Nikolaou","year":"2012","journal-title":"Dermatology"},{"key":"2026090306520096400_llag346-B6","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nrc1970","article-title":"Mechanisms of cutaneous toxicities to EGFR inhibitors","volume":"6","author":"Lacouture","year":"2006","journal-title":"Nat Rev 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inhibitors","volume":"16","author":"Segaert","year":"2005","journal-title":"Ann Oncol"}],"container-title":["Clinical and Experimental 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