{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:45:07Z","timestamp":1792143907314,"version":"4.4.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cutaneous T-cell lymphomas (CTCLs) comprise a clinically, histologically and molecularly heterogeneous group of subtypes. They fulfil aspects of both chronic and malignant skin conditions and may thus affect health-related quality of life (HRQL) in various ways. To date, there is little information known about the topology of patients with CTCL in routine care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize the frequency and distribution of body sites affected by CTCLs in routine care and to analyse the impact on HRQL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross-sectional survey study, as part of the routine care at a university medical centre. Topical distribution was identified with a detailed grid scheme filled in by the patient, and the affected body surface area (BSA) was recorded by the physician. Skindex-29 measured HRQL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 153 patients with CTCL were included, with a mean age of 59.5 (SD 16.5) years and the majority were male patients (61.4%, 94\/153). The mean number of grids marked was 129.2 (SD 263.8), corresponding to 12.7% of the BSA, and the most frequently affected body areas were thighs, back and lower legs. Skindex-29 revealed that HRQL in patients with CTCL is impaired on a mild level, with a mean of 27.5 (SD 21.3). Patients with involvement of the visible or genital areas showed a significantly poorer HRQL. Overall, 70.0% (107\/153) of patients reported relevant pruritus (numeric rating scale \u2265 3), which was strongly associated with worse HRQL, independent of localization. Linear regression analysis revealed a significant correlation between an increased impairment of HRQL and a higher BSA, a manifestation in visible areas, and a higher itching intensity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This analysis provides data on the distribution of CTCLs in routine care. Our study highlights the importance of specific areas, such as visible body areas or the genital area, as determinants for the reduction of HRQL. This knowledge can help to improve patient-centred healthcare in CTCL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llag358","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:32:33Z","timestamp":1788258753000},"source":"Crossref","is-referenced-by-count":0,"title":["Topology and the impact on quality of life of cutaneous T-cell lymphomas: a cross-sectional study of 153 patients"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5579-4337","authenticated-orcid":false,"given":"Inga","family":"Hansen-Abeck","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"K\u00f6lln","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Heidrich","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Abeck","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"K\u00f6tt","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan W","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University 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