{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:07:32Z","timestamp":1790075252125,"version":"4.0.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D has been hypothesized to influence melanoma risk and progression, but observational findings are confounded by ultraviolet exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the effect of vitamin D supplementation on melanoma recurrence and melanoma incidence using randomized controlled trial (RCT) evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A PRISMA-guided systematic review and meta-analysis identified RCTs evaluating oral vitamin D supplementation, with or without calcium, reporting melanoma incidence or recurrence. Hazard ratios (HRs) were pooled for recurrence and relative risks (RRs) for incidence using random-effects models with the Hartung\u2013Knapp\u2013Sidik\u2013Jonkman (HKSJ) correction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five RCTs including 56,901 participants met inclusion criteria. Vitamin D supplementation was not associated with reduced melanoma recurrence (pooled HR 1.23; 95% CI 0.29\u20135.18; HKSJ-adjusted) or melanoma incidence (pooled RR 0.94; 95% CI 0.71\u20131.24; HKSJ-adjusted). Findings were consistent across varied dosing regimens and follow-up durations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>Melanoma was a secondary endpoint in some trials, event rates were low, and dosing regimens varied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Current randomized evidence does not support vitamin D supplementation as a strategy to reduce melanoma incidence or recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ced\/llag418","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:42:15Z","timestamp":1790073735000},"source":"Crossref","is-referenced-by-count":0,"title":["Vitamin D Supplementation and Melanoma Incidence and Recurrence: A Meta-analysis of Randomized Controlled Trials"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3686-9692","authenticated-orcid":false,"given":"Christian","family":"Roberti","sequence":"first","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine , Bradenton, FL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savannah","family":"Chapman","sequence":"additional","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine , Bradenton, FL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine , Bradenton, FL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Paul","family":"Lemchak","sequence":"additional","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine , Bradenton, FL ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Mueller","sequence":"additional","affiliation":[{"name":"Sturdy Memorial Hospital , Attleboro, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,22]]},"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llag418\/71309994\/llag418.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llag418\/71309994\/llag418.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:42:15Z","timestamp":1790073735000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/advance-article\/doi\/10.1093\/ced\/llag418\/8827465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ced\/llag418","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]},"article-number":"llag418"}}