{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:54:12Z","timestamp":1792011252633,"version":"4.4.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>We conducted a systematic review of studies that have investigated the association between prescribed insulin for type 2 diabetes and the risk of skin cancer. Four studies met the inclusion criteria, one trial and three cohort studies. Of these, all bar one were high-quality. The majority of studies report no statistically significant association and the direction was inconsistent. Future research should evaluate the effect of different insulin analogues, dosages, and exposure periods, and consider confounding by indication.<\/jats:p>","DOI":"10.1093\/ced\/llag444","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:36:11Z","timestamp":1791891371000},"source":"Crossref","is-referenced-by-count":0,"title":["Prescribed insulin use in type II diabetes mellitus and skin cancer risk: A systematic review 3"],"prefix":"10.1093","author":[{"given":"Adele","family":"Sotgiu","sequence":"first","affiliation":[{"name":"School of Medicine, University of Nottingham , Nottingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9526-7899","authenticated-orcid":false,"given":"Girum","family":"Assefa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hawassa University ,","place":["Ethiopia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Tutt","sequence":"additional","affiliation":[{"name":"Centre of Evidence-Based Dermatology, School of Medicine, University of Nottingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Baby","sequence":"additional","affiliation":[{"name":"Foundation Year 2, University Hospitals of Leicester NHS Trust , Leicester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe C","family":"Venables","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia , Norwich ,","place":["UK"]},{"name":"Norfolk and Norwich University Hospital , Norwich ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-074X","authenticated-orcid":false,"given":"Zenas Z N","family":"Yiu","sequence":"additional","affiliation":[{"name":"Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, NIHR Manchester Biomedical Research Centre, The University of Manchester ,","place":["UK"]},{"name":"Department of Dermatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre , Manchester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley E","family":"Rhodes","sequence":"additional","affiliation":[{"name":"Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, NIHR Manchester Biomedical Research Centre, The University of Manchester ,","place":["UK"]},{"name":"Department of Dermatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre , Manchester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iskandar","family":"Idris","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Nottingham , Nottingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2443-5100","authenticated-orcid":false,"given":"Sonia","family":"Gran","sequence":"additional","affiliation":[{"name":"Centre of Evidence-Based Dermatology, School of Medicine, University of Nottingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,14]]},"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llag444\/71948519\/llag444.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/advance-article-pdf\/doi\/10.1093\/ced\/llag444\/71948519\/llag444.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:42:03Z","timestamp":1792010523000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/advance-article\/doi\/10.1093\/ced\/llag444\/8916644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ced\/llag444","relation":{},"ISSN":["0307-6938","1365-2230"],"issn-type":[{"value":"0307-6938","type":"print"},{"value":"1365-2230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"article-number":"llag444"}}