{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:16:27Z","timestamp":1787008587914,"version":"build-2736575974"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T00:00:00Z","timestamp":1638662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Program of Platform Construction of Shenyang, Liaoning, China","award":["19-109-4-15"],"award-info":[{"award-number":["19-109-4-15"]}]},{"name":"Clinical Medical Research Center of Shenyang","award":["18009-4-03"],"award-info":[{"award-number":["18009-4-03"]}]},{"name":"Clinical Medical Research Center of Shenyang","award":["20-204-4-43"],"award-info":[{"award-number":["20-204-4-43"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing family member 6 (CMTM6), which is a key regulator of programmed death-1 (PD-1)\/programmed death ligand-1 (PD-L1) signaling in patients with primary Sj\u00f6gren\u2019s syndrome (pSS). In this study, we analyzed the serum levels of CMTM6, PD-1, and PD-L1 in 50 patients with pSS, 42 patients with non-pSS (simply dry mouth and\/or eyes symptoms) and 50 healthy controls (HC). The expression of CMTM6, PD-1, and PD-L1 in labial glands of the same 50 pSS patients and 42 non-pSS patients were assessed by immunohistochemistry (IHC). The clinical significance of CMTM6, PD-1, and PD-L1 were analyzed. We found that levels of CMTM6, PD-L1 as well as PD-1 in sera were all increased significantly in patients with pSS compared with non-pSS controls and HC. Serum CMTM6 level showed significantly correlation with PD-L1, PD-1, as well as clinical laboratory indicators and disease activity of pSS patients. CMTM6, PD-1, and PD-L1 expression in labial glands was also higher significantly in pSS patients than non-pSS controls. pSS patients with higher CM grade or ESSDAI score have higher CMTM6, PD-L1, and PD-1 expression in labial glands. These results suggest that CMTM6 may affect peripheral tolerance and lymphocytes activation by PD-1\/PD-L1 pathway in sera and target tissue in pSS.<\/jats:p>","DOI":"10.1093\/cei\/uxab003","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T13:52:46Z","timestamp":1641995566000},"page":"65-71","source":"Crossref","is-referenced-by-count":6,"title":["CMTM6: increased circulating level and up-regulated expression in labial salivary glands in patients with primary Sjogren\u2019s syndrome"],"prefix":"10.1093","volume":"207","author":[{"given":"Sirui","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingting","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, First Affiliated Hospital, China Medical University, Shenyang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7377-7249","authenticated-orcid":false,"given":"Chunshu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of 1st Cancer Institute, First Affiliated Hospital, China Medical University, Shenyang, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,5]]},"reference":[{"key":"2022042107315546000_CIT0001","doi-asserted-by":"crossref","first-page":"e3821","DOI":"10.1136\/bmj.e3821","article-title":"Primary Sjogren syndrome.","volume":"344","author":"Ramos-Casals","year":"2012","journal-title":"BMJ"},{"key":"2022042107315546000_CIT0002","first-page":"97","article-title":"Primary Sj\u00f6gren\u2019s syndrome.","volume":"379","author":"Mariette","year":"2018","journal-title":"N Engl J Med"},{"key":"2022042107315546000_CIT0003","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jaut.2009.10.004","article-title":"Characteristics of the minor salivary gland infiltrates in Sj\u00f6gren\u2019s syndrome.","volume":"34","author":"Christodoulou","year":"2010","journal-title":"J 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