{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:31:45Z","timestamp":1779931905612,"version":"3.53.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["20960"],"award-info":[{"award-number":["20960"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["21139"],"award-info":[{"award-number":["21139"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["22272"],"award-info":[{"award-number":["22272"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>MicroRNAs (miRs) are known to regulate pro-inflammatory effector functions of myeloid cells, and miR dysregulation is implicated in rheumatoid arthritis (RA), a condition characterized by inflammation and destruction of the joints. We showed previously that miR-155 is increased in myeloid cells in RA and induces pro-inflammatory activation of monocytes and macrophages; however, its role at the interface between innate and adaptive immunity was not defined. Here, RNA-sequencing revealed that overexpression of miR-155 in healthy donor monocytes conferred a specific gene profile which bears similarities to that of RA synovial fluid-derived CD14+ cells and HLAhighISG15+ synovial tissue macrophages, both of which are characterized by antigen-presenting pathways. In line with this, monocytes in which miR-155 was overexpressed, displayed increased expression of HLA-DR and both co-stimulatory and co-inhibitory molecules, and induced activation of polyfunctional T cells. Together, these data underpin the notion that miR-155-driven myeloid cell activation in the synovium contributes not only to inflammation but may also influence the adaptive immune response.<\/jats:p>","DOI":"10.1093\/cei\/uxab016","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T18:52:30Z","timestamp":1642013550000},"page":"188-198","source":"Crossref","is-referenced-by-count":13,"title":["miR-155-overexpressing monocytes resemble HLAhighISG15+ synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T-cell activation"],"prefix":"10.1093","volume":"207","author":[{"given":"Anton M","family":"Olsson","sequence":"first","affiliation":[{"name":"Centre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni A M","family":"Povoleri","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Somma","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L","family":"Ridley","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King\u2019s College London, London, UK"},{"name":"GSK, Stevenage, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Rizou","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King\u2019s College London, London, UK"},{"name":"Francis Crick Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvine","family":"Lalnunhlimi","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Macdonald","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, UK"},{"name":"Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha","family":"Rajasekhar","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King\u2019s College London, London, UK"},{"name":"Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio T","family":"Martinez-Nunez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, School of Immunology & Microbial Sciences, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariola","family":"Kurowska-Stolarska","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, UK"},{"name":"Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9337-7194","authenticated-orcid":false,"given":"Leonie S","family":"Taams","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Biology and Cancer Immunology, Department of Inflammation Biology, School of Immunology and Microbial Sciences, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"2022040512182025200_CIT0001","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3389\/fimmu.2015.00571","article-title":"The interplay between monocytes\/macrophages and CD4(+) T cell subsets in rheumatoid arthritis.","volume":"6","author":"Roberts","year":"2015","journal-title":"Front Immunol"},{"key":"2022040512182025200_CIT0002","doi-asserted-by":"crossref","first-page":"e109775","DOI":"10.1371\/journal.pone.0109775","article-title":"Functional phenotype of synovial monocytes modulating inflammatory T-cell responses in rheumatoid arthritis (RA).","volume":"9","author":"Yoon","year":"2014","journal-title":"PLoS One"},{"key":"2022040512182025200_CIT0003","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/art.37832","article-title":"Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cells.","volume":"65","author":"Walter","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2022040512182025200_CIT0004","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.1073\/pnas.0808144106","article-title":"In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses.","volume":"106","author":"Evans","year":"2009","journal-title":"Proc Natl Acad Sci 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II. Low levels of synovial fluid and synovial tissue interferon suggest that gamma-interferon is not the primary macrophage activating factor.","volume":"30","author":"Firestein","year":"1987","journal-title":"Arthritis Rheum"},{"key":"2022040512182025200_CIT0006","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2249.1995.tb03850.x","article-title":"Changes in the phenotype of monocytes\/macrophages and expression of cytokine mRNA in peripheral blood and synovial fluid of patients with rheumatoid arthritis.","volume":"102","author":"Highton","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"2022040512182025200_CIT0007","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.3389\/fimmu.2017.01932","article-title":"MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis.","volume":"8","author":"Alivernini","year":"2017","journal-title":"Front 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