{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T12:19:50Z","timestamp":1767183590340,"version":"3.37.3"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005317","name":"Kermanshah University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the patients with neurological autoimmune diseases such as anti-IgLON5 disease, insomnia symptoms are very common. Clinical diagnosis of the anti-IgLON5 disease is usually made when neurodegenerative processes have occurred. To find the early signs of anti-IgLON5 disease, we evaluate the presence of IgLON5 autoantibodies in the serum of patients with chronic insomnia disease. Based on video-polysomnography, 22 individuals with isolated chronic insomnia disease were found. A control group of 22 healthy people was chosen using the Pittsburgh Sleep Quality Index (PSQI). An indirect immunofluorescence cell-based test of serum anti-IgLON5 antibodies was used to investigate IgLON5 autoimmunity. Anti-IgLON5 antibodies were detected in the serum of four of these patients with the titer of 1\/10. The presence of IgLON5 autoantibodies in some patients with chronic insomnia disease can be considered a causing factor of insomnia which can be effective in more specific treatments of these patients. Moreover, the recognition of anti-IgLON5 disease in the early stages and before the progression of tauopathies can be useful in effective and timely treatment.<\/jats:p>","DOI":"10.1093\/cei\/uxab017","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T18:52:33Z","timestamp":1642013553000},"page":"237-240","source":"Crossref","is-referenced-by-count":4,"title":["IgLON5 autoimmunity tested positive in patients with isolated chronic insomnia disease"],"prefix":"10.1093","volume":"207","author":[{"given":"Zahra","family":"Aghelan","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Karima","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, School of Medicine, Shahid Behehshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Rasoul","family":"Ghadami","sequence":"additional","affiliation":[{"name":"Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habibolah","family":"Khazaie","sequence":"additional","affiliation":[{"name":"Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariborz","family":"Bahrehmand","sequence":"additional","affiliation":[{"name":"Medical Biology Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asad","family":"Vaisi-Raygani","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Hosein","family":"Abtahi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Behehshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Khodarahmi","sequence":"additional","affiliation":[{"name":"Medical Biology Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"2022040512175521400_CIT0001","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s11606-016-3717-z","article-title":"Risk of autoimmune disease in adults with chronic insomnia requiring sleep-inducing pills: a population-based longitudinal study.","volume":"31","author":"Kok","year":"2016","journal-title":"J Gen Intern Med"},{"key":"2022040512175521400_CIT0002","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1152\/physrev.00010.2016","article-title":"Autoantibodies to synaptic receptors and neuronal cell surface proteins in autoimmune diseases of the central nervous system.","volume":"97","author":"Dalmau","year":"2017","journal-title":"Physiol Rev"},{"key":"2022040512175521400_CIT0003","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41386-019-0463-z","article-title":"Sleep and neurological autoimmune diseases.","volume":"45","author":"Iranzo","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"2022040512175521400_CIT0004","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3233\/JND-170259","article-title":"Expanding the clinical spectrum of IgLON5-syndrome.","volume":"4","author":"Wenninger","year":"2017","journal-title":"J Neuromuscul Dis"},{"key":"2022040512175521400_CIT0005","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00401-016-1591-8","article-title":"Neuropathological criteria of anti-IgLON5-related tauopathy.","volume":"132","author":"Gelpi","year":"2016","journal-title":"Acta Neuropathol"},{"key":"2022040512175521400_CIT0006","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3233\/JAD-170189","article-title":"Microglial and neuronal TDP-43 pathology in anti-IgLON5-related tauopathy.","volume":"59","author":"Cagnin","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"2022040512175521400_CIT0007","doi-asserted-by":"crossref","first-page":"5764017","DOI":"10.1155\/2020\/5764017","article-title":"Sleep deprivation and neurological disorders.","volume":"2020","author":"Bishir","year":"2020","journal-title":"Biomed Res Int"},{"key":"2022040512175521400_CIT0008","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fpsyt.2018.00255","article-title":"Rapid eye movement sleep, sleep continuity and slow wave sleep as predictors of cognition, mood, and subjective sleep quality in healthy men and women, aged 20-84 years.","volume":"9","author":"Della Monica","year":"2018","journal-title":"Front Psychiatry"},{"key":"2022040512175521400_CIT0009","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12974-020-01960-9","article-title":"The effect of insomnia on development of Alzheimer\u2019s disease.","volume":"17","author":"Sadeghmousavi","year":"2020","journal-title":"J Neuroinflammation"},{"key":"2022040512175521400_CIT0010","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1111\/ene.13566","article-title":"IgLON5 antibodies are infrequent in patients with isolated sleep apnea.","volume":"25","author":"Hasselbacher","year":"2018","journal-title":"Eur J Neurol"},{"key":"2022040512175521400_CIT0011","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1126\/science.aav2546","article-title":"The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans.","volume":"363","author":"Holth","year":"2019","journal-title":"Science"}],"container-title":["Clinical and Experimental 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