{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:19:34Z","timestamp":1791811174095,"version":"4.3.4"},"reference-count":134,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Experimental findings suggest an involvement of neuroinflammatory mechanisms in the pathophysiology of migraine. Specifically, preclinical models of migraine have emphasized the role of neuroinflammation following the activation of the trigeminal pathway at several peripheral and central sites including dural vessels, the trigeminal ganglion, and the trigeminal nucleus caudalis. The evidence of an induction of inflammatory events in migraine pathophysiological mechanisms has prompted researchers to investigate the human leukocyte antigen (HLA) phenotypes as well as cytokine genetic polymorphisms in order to verify their potential relationship with migraine risk and severity. Furthermore, the role of neuroinflammation in migraine seems to be supported by evidence of an increase in pro-inflammatory cytokines, both ictally and interictally, together with the prevalence of Th1 lymphocytes and a reduction in regulatory lymphocyte subsets in peripheral blood of migraineurs. Cytokine profiles of cluster headache (CH) patients and those of tension-type headache patients further suggest an immunological dysregulation in the pathophysiology of these primary headaches, although evidence is weaker than for migraine. The present review summarizes available findings to date from genetic and biomarker studies that have explored the role of inflammation in primary headaches.<\/jats:p>","DOI":"10.1093\/cei\/uxab025","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T18:52:15Z","timestamp":1642013535000},"page":"11-26","source":"Crossref","is-referenced-by-count":47,"title":["Immunological findings in patients with migraine and other primary headaches: a narrative review"],"prefix":"10.1093","volume":"207","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2878-9432","authenticated-orcid":false,"given":"Leonardo","family":"Biscetti","sequence":"first","affiliation":[{"name":"Istituto Nazionale di Riposo e Cura dell\u2019Anziano a carattere scientifico, IRCSS-INRCA, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioacchino","family":"De Vanna","sequence":"additional","affiliation":[{"name":"Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Cresta","sequence":"additional","affiliation":[{"name":"Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Bellotti","sequence":"additional","affiliation":[{"name":"Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"Corbelli","sequence":"additional","affiliation":[{"name":"Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Letizia Cupini","sequence":"additional","affiliation":[{"name":"UOC Neurologia, Ospedale Sant\u2019Eugenio, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Calabresi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Universit\u00e0 Cattolica Sacro Cuore, Rome, Italy"},{"name":"Neurologia, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Sarchielli","sequence":"additional","affiliation":[{"name":"Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,27]]},"reference":[{"key":"2022040410020858500_CIT0001","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.2174\/1381612825666190709204107","article-title":"Novelty in inflammation and immunomodulation in migraine.","volume":"25","author":"Cavestro","year":"2019","journal-title":"Curr Pharm Des"},{"issue":"1","key":"2022040410020858500_CIT0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"The International Classification of Headache Disorders, 3rd edition.","volume":"38","author":"Headache Classification Committee of the International Headache Society (IHS).","year":"2018","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0003","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1177\/0333102419867280","article-title":"Hypothalamic regulation of headache and migraine.","volume":"39","author":"May","year":"2019","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0004","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1523\/JNEUROSCI.07-12-04129.1987","article-title":"Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain.","volume":"7","author":"Markowitz","year":"1987","journal-title":"J Neurosci"},{"key":"2022040410020858500_CIT0005","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0306-4522(91)90253-K","article-title":"Trigeminal sensory fiber stimulation induces morphological changes reflecting secretion in rat dura mater mast cells.","volume":"44","author":"Dimitriadou","year":"1991","journal-title":"Neuroscience"},{"key":"2022040410020858500_CIT0006","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/j.1476-5381.1991.tb09805.x","article-title":"Further characterization of the putative 5-HT receptor which mediates blockade of neurogenic plasma extravasation in rat dura mater.","volume":"103","author":"Buzzi","year":"1991","journal-title":"Br J Pharmacol"},{"key":"2022040410020858500_CIT0007","first-page":"245","article-title":"An overview on immune system and migraine.","volume":"11","author":"Bruno","year":"2007","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2022040410020858500_CIT0008","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejphar.2018.12.004","article-title":"Progression in migraine: Role of mast cells and pro-inflammatory and anti-inflammatory cytokines.","volume":"844","author":"Conti","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"2022040410020858500_CIT0009","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00441-003-0779-0","article-title":"Macrophages and dendritic cells in the rat meninges and choroid plexus: three-dimensional localisation by environmental scanning electron microscopy and confocal microscopy.","volume":"313","author":"McMenamin","year":"2003","journal-title":"Cell Tissue Res"},{"key":"2022040410020858500_CIT0010","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.pneurobio.2017.05.002","article-title":"Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brain.","volume":"156","author":"Coles","year":"2017","journal-title":"Prog Neurobiol"},{"key":"2022040410020858500_CIT0011","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.immuni.2015.08.016","article-title":"Nociceptive sensory fibers drive interleukin-23 production from CD301b+ dermal dendritic cells and drive protective cutaneous immunity.","volume":"43","author":"Kashem","year":"2015","journal-title":"Immunity"},{"key":"2022040410020858500_CIT0012","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nm.3852","article-title":"The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase.","volume":"21","author":"Vicu\u00f1a","year":"2015","journal-title":"Nat Med"},{"key":"2022040410020858500_CIT0013","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41582-019-0216-y","article-title":"Does inflammation have a role in migraine?","volume":"15","author":"Edvinsson","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"2022040410020858500_CIT0014","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/0333102417691762","article-title":"CGRP receptor antagonist activity of olcegepant depends on the signalling pathway measured.","volume":"38","author":"Walker","year":"2018","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0015","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/00004647-200103000-00005","article-title":"Cortical spreading depression induces proinflammatory cytokine gene expression in the rat brain.","volume":"21","author":"Jander","year":"2001","journal-title":"J Cereb Blood Flow Metab"},{"key":"2022040410020858500_CIT0016","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1097\/01.WCB.0000126566.34753.30","article-title":"Multiplexed cytokine protein expression profiles from spreading depression in hippocampal organotypic cultures.","volume":"24","author":"Kunkler","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"key":"2022040410020858500_CIT0017","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1385\/MN:32:1:051","article-title":"Cortical spreading depression modifies components of the inflammatory cascade.","volume":"32","author":"Thompson","year":"2005","journal-title":"Mol Neurobiol"},{"key":"2022040410020858500_CIT0018","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1460-9568.2006.04862.x","article-title":"Microarray-based long-term detection of genes differentially expressed after cortical spreading depression.","volume":"24","author":"Urbach","year":"2006","journal-title":"Eur J Neurosci"},{"key":"2022040410020858500_CIT0019","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1177\/0333102417702132","article-title":"Astrocyte-mediated inflammation in cortical spreading depression.","volume":"38","author":"Ghaemi","year":"2018","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0020","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s12031-020-01788-1","article-title":"A comprehensive review on the role of genetic factors in the pathogenesis of migraine.","volume":"71","author":"Ebahimzadeh","year":"2021","journal-title":"J Mol Neurosci"},{"key":"2022040410020858500_CIT0021","doi-asserted-by":"crossref","first-page":"e2407","DOI":"10.1136\/bmj.e2407","article-title":"Cluster headache.","volume":"344","author":"Nesbitt","year":"2012","journal-title":"BMJ"},{"key":"2022040410020858500_CIT0022","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/brain\/117.3.427","article-title":"Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies.","volume":"117","author":"Goadsby","year":"1994","journal-title":"Brain"},{"key":"2022040410020858500_CIT0023","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/oxfordjournals.bmb.a072189","article-title":"Peptides and neurogenic inflammation.","volume":"43","author":"Foreman","year":"1987","journal-title":"Br Med Bull"},{"key":"2022040410020858500_CIT0024","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0959-4388(02)00340-9","article-title":"Endovanilloid signaling in pain.","volume":"12","author":"Di Marzo","year":"2002","journal-title":"Curr Opin Neurobiol"},{"key":"2022040410020858500_CIT0025","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S1474-4422(07)70325-3","article-title":"Tension-type headache: current research and clinical management.","volume":"7","author":"Fumal","year":"2008","journal-title":"Lancet Neurol"},{"key":"2022040410020858500_CIT0026","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/sji.12329","article-title":"Clinical role of human leukocyte antigen in health and disease.","volume":"82","author":"Mosaad","year":"2015","journal-title":"Scand J Immunol"},{"key":"2022040410020858500_CIT0027","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0198-8859(98)00087-1","article-title":"Chromosome 6p-encoded HLA-DR2 determination discriminates migraine without aura from migraine with aura.","volume":"60","author":"Martelletti","year":"1999","journal-title":"Hum Immunol"},{"key":"2022040410020858500_CIT0028","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10194-005-0180-3","article-title":"Association between migraine and HLA-DRB1 gene polymorphisms.","volume":"6","author":"Rainero","year":"2005","journal-title":"J Headache Pain"},{"key":"2022040410020858500_CIT0029","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1526-4610.1978.hed1803167.x","article-title":"HL-A antigens in cluster headache and classical migraine.","volume":"18","author":"Kudrow","year":"1978","journal-title":"Headache"},{"key":"2022040410020858500_CIT0030","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/0333102420902228","article-title":"HLA class I alleles are associated with clinic-based migraine and increased risks of chronic migraine and medication overuse.","volume":"40","author":"Huang","year":"2020","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0031","first-page":"32","article-title":"Relevance of the tumor necrosis factor alpha (TNF alpha) -308 promoter polymorphism in TNF alpha gene regulation.","volume":"46","author":"Brinkman","year":"1995","journal-title":"J Inflamm"},{"key":"2022040410020858500_CIT0032","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bbadis.2009.01.007","article-title":"Tumor necrosis factor alpha -308 gene locus promoter polymorphism: an analysis of association with health and disease.","volume":"1792","author":"Elahi","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"2022040410020858500_CIT0033","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1212\/01.WNL.0000101717.16799.8F","article-title":"Association between the tumor necrosis factor-alpha -308 G\/A gene polymorphism and migraine.","volume":"62","author":"Rainero","year":"2004","journal-title":"Neurology"},{"key":"2022040410020858500_CIT0034","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1163\/156856905774482814","article-title":"The -308 G\/A polymorphism of tumor necrosis factor alpha gene is not associated with migraine.","volume":"17","author":"Herken","year":"2005","journal-title":"Pain Clinic"},{"key":"2022040410020858500_CIT0035","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s00415-006-0270-4","article-title":"The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with migraine without aura.","volume":"253","author":"Mazaheri","year":"2006","journal-title":"J Neurol"},{"key":"2022040410020858500_CIT0036","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/j.1526-4610.2007.00847.x","article-title":"Association between a polymorphism in the lymphotoxin-a promoter region and migraine.","volume":"47","author":"Lee","year":"2007","journal-title":"Headache"},{"key":"2022040410020858500_CIT0037","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1007\/s00415-009-5430-x","article-title":"Investigation of TNFA 308G &gt; A and TNFB 252G &gt; A polymorphisms in genetic susceptibility to migraine.","volume":"257","author":"Ghosh","year":"2010","journal-title":"J Neurol"},{"key":"2022040410020858500_CIT0038","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1526-4637.2009.00791.x","article-title":"Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation.","volume":"11","author":"Yilmaz","year":"2010","journal-title":"Pain Med"},{"key":"2022040410020858500_CIT0039","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1111\/j.1526-4637.2011.01200.x","article-title":"Genetic variations in tumor necrosis factor alpha, interleukin-10 genes, and migraine susceptibility.","volume":"12","author":"Ates","year":"2011","journal-title":"Pain Med"},{"key":"2022040410020858500_CIT0040","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1017\/thg.2013.63","article-title":"Genetic variation in cytokine-related genes and migraine susceptibility.","volume":"16","author":"Stuart","year":"2013","journal-title":"Twin Res Hum Genet"},{"key":"2022040410020858500_CIT0041","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1177\/0333102411419022","article-title":"Tumour necrosis factor gene polymorphisms and migraine: a systematic review and meta-analysis.","volume":"31","author":"Sch\u00fcrks","year":"2011","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0042","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3892\/etm.2012.533","article-title":"The TNF-\u03b1-308G\/A polymorphism is associated with migraine risk: a meta-analysis.","volume":"3","author":"Gu","year":"2012","journal-title":"Exp Ther Med"},{"key":"2022040410020858500_CIT0043","doi-asserted-by":"crossref","first-page":"e0129372","DOI":"10.1371\/journal.pone.0129372","article-title":"Tumor necrosis factor (TNF) -308G&gt;A, nitric oxide synthase 3 (NOS3) +894G&gt;T polymorphisms and migraine risk: a meta-analysis.","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"2022040410020858500_CIT0044","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jns.2014.11.009","article-title":"Influence of tumor necrosis factor alpha gene promoter polymorphisms and its serum level on migraine susceptibility in Egyptian patients.","volume":"348","author":"Fawzi","year":"2015","journal-title":"J Neurol Sci"},{"key":"2022040410020858500_CIT0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1532\/IJH97.05120","article-title":"Tumor necrosis factor\/tumor necrosis factor receptor family members that positively regulate immunity.","volume":"83","author":"So","year":"2006","journal-title":"Int J Hematol"},{"key":"2022040410020858500_CIT0046","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.molimm.2007.04.012","article-title":"Differential expression of new LTA splice variants upon lymphocyte activation.","volume":"45","author":"Smirnova","year":"2008","journal-title":"Mol Immunol"},{"key":"2022040410020858500_CIT0047","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1526-4610.2002.02104.x","article-title":"Tumor necrosis factor gene polymorphism in migraine.","volume":"42","author":"Trabace","year":"2002","journal-title":"Headache"},{"key":"2022040410020858500_CIT0048","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s00415-009-0961-8","article-title":"Migraine and tumour necrosis factor gene polymorphism. An association study in a Sardinian sample.","volume":"256","author":"Asuni","year":"2009","journal-title":"J Neurol"},{"key":"2022040410020858500_CIT0049","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s11010-011-1188-4","article-title":"MAOA, MTHFR, and TNF-\u03b2 genes polymorphisms and personality traits in the pathogenesis of migraine.","volume":"363","author":"Ishii","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"2022040410020858500_CIT0050","doi-asserted-by":"crossref","first-page":"e100189","DOI":"10.1371\/journal.pone.0100189","article-title":"Effects of tumor necrosis factor-\u03b2 (TNF-\u03b2) 252A&gt;G polymorphism on the development of migraine: a meta-analysis.","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"2022040410020858500_CIT0051","first-page":"40","article-title":"MAOA and TNF-\u03b2 gene polymorphisms are associated with photophobia but not osmophobia in patients with migraine.","volume":"23","author":"Ishii","year":"2014","journal-title":"Acta Neurol Taiwan"},{"key":"2022040410020858500_CIT0052","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.gene.2012.09.116","article-title":"Investigation of lymphotoxin \u03b1 genetic variants in migraine.","volume":"512","author":"Oikari","year":"2013","journal-title":"Gene"},{"key":"2022040410020858500_CIT0053","doi-asserted-by":"crossref","DOI":"10.1007\/s10072-020-04967-5","article-title":"Association between tumor necrosis factor alpha and lymphotoxin alpha gene polymorphisms and migraine occurrence among Jordanians.","author":"Hamad","year":"2021","journal-title":"Neurol Sci"},{"key":"2022040410020858500_CIT0054","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1129-2377-15-62","article-title":"Genetic association and gene expression studies suggest that genetic variants in the SYNE1 and TNF genes are related to menstrual migraine.","volume":"15","author":"Rodriguez-Acevedo","year":"2014","journal-title":"J Headache Pain"},{"key":"2022040410020858500_CIT0055","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1526-4610.2002.02103.x","article-title":"A polymorphism in the interleukin-1alpha gene influences the clinical features of migraine.","volume":"42","author":"Rainero","year":"2002","journal-title":"Headache"},{"key":"2022040410020858500_CIT0056","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/art.1780380210","article-title":"A genetic association between juvenile rheumatoid arthritis and a novel interleukin-1 alpha polymorphism.","volume":"38","author":"McDowell","year":"1995","journal-title":"Arthritis Rheum"},{"key":"2022040410020858500_CIT0057","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/1531-8249(200003)47:3<361::AID-ANA12>3.0.CO;2-N","article-title":"Association of early-onset Alzheimer\u2019s disease with an interleukin-1alpha gene polymorphism.","volume":"47","author":"Grimaldi","year":"2000","journal-title":"Ann Neurol"},{"key":"2022040410020858500_CIT0058","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/1531-8249(200003)47:3<365::AID-ANA13>3.0.CO;2-G","article-title":"Association of interleukin-1 gene polymorphisms with Alzheimer\u2019s disease.","volume":"47","author":"Nicoll","year":"2000","journal-title":"Ann Neurol"},{"key":"2022040410020858500_CIT0059","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-3940(03)00304-5","article-title":"Absence of linkage between the interleukin-6 gene (-174 G\/C) polymorphism and migraine.","volume":"343","author":"Rainero","year":"2003","journal-title":"Neurosci Lett"},{"key":"2022040410020858500_CIT0060","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s10194-005-0181-2","article-title":"Cytotoxic T lymphocyte antigen 4 polymorphism 49 (A&gt;G) and migraine.","volume":"6","author":"Lulli","year":"2005","journal-title":"J Headache Pain"},{"key":"2022040410020858500_CIT0061","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.2147\/NDT.S109414","article-title":"Association between sequence variations of the Mediterranean fever gene and the risk of migraine: a case-control study.","volume":"12","author":"Co\u015fkun","year":"2016","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2022040410020858500_CIT0062","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jpain.2009.01.326","article-title":"A candidate gene association study of 77 polymorphisms in migraine.","volume":"10","author":"Sch\u00fcrks","year":"2009","journal-title":"J Pain"},{"key":"2022040410020858500_CIT0063","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/ng.3598","article-title":"Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.","volume":"48","author":"Gormley","year":"2016","journal-title":"Nat Genet"},{"key":"2022040410020858500_CIT0064","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/jcp.21706","article-title":"Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis.","volume":"219","author":"Ferrari","year":"2009","journal-title":"J Cell Physiol"},{"key":"2022040410020858500_CIT0065","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.semcdb.2019.12.010","article-title":"TGF-\u03b21 - A truly transforming growth factor in fibrosis and immunity.","volume":"101","author":"Lodyga","year":"2020","journal-title":"Semin Cell Dev Biol"},{"key":"2022040410020858500_CIT0066","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000057361","article-title":"Role of TGF-beta in vascular development and vascular reactivity.","volume":"24","author":"Perrella","year":"1998","journal-title":"Miner Electrolyte Metab"},{"key":"2022040410020858500_CIT0067","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/cr.2008.326","article-title":"TGF-beta signaling in vascular biology and dysfunction.","volume":"19","author":"Goumans","year":"2009","journal-title":"Cell Res"},{"key":"2022040410020858500_CIT0068","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1046\/j.1468-2982.2001.00196.x","article-title":"Migraine and function of the immune system: a meta-analysis of clinical literature published between 1966 and 1999.","volume":"21","author":"Kemper","year":"2001","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0069","first-page":"1111","article-title":"Serum cytokine and pro-brain natriuretic peptide (BNP) levels in patients with migraine.","volume":"15","author":"Uzar","year":"2011","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2022040410020858500_CIT0070","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10072-014-1931-1","article-title":"Increased interictal serum levels of CXCL8\/IL-8 and CCL3\/MIP-1\u03b1 in migraine.","volume":"36","author":"Duarte","year":"2015","journal-title":"Neurol Sci"},{"key":"2022040410020858500_CIT0071","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jneuroim.2017.09.008","article-title":"Unbalanced plasma TNF-\u03b1 and IL-12\/IL-10 profile in women with migraine is associated with psychological and physiological outcomes.","volume":"313","author":"Oliveira","year":"2017","journal-title":"J Neuroimmunol"},{"key":"2022040410020858500_CIT0072","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1526-4610.2005.05135.x","article-title":"Plasma cytokine levels in migraineurs and controls.","volume":"45","author":"Perini","year":"2005","journal-title":"Headache"},{"key":"2022040410020858500_CIT0073","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pediatrneurol.2009.02.001","article-title":"Proinflammatory plasma cytokines in children with migraine.","volume":"41","author":"Bo\u0107kowski","year":"2009","journal-title":"Pediatr Neurol"},{"key":"2022040410020858500_CIT0074","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1734-1140(10)70268-1","article-title":"Anti-inflammatory plasma cytokines in children and adolescents with migraine headaches.","volume":"62","author":"Bo\u0107kowski","year":"2010","journal-title":"Pharmacol Rep"},{"key":"2022040410020858500_CIT0075","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/j.1526-4610.2005.00246.x","article-title":"Increased plasma transforming growth factor-beta1 in migraine.","volume":"45","author":"Ishizaki","year":"2005","journal-title":"Headache"},{"key":"2022040410020858500_CIT0076","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1046\/j.1526-4610.1998.3806465.x","article-title":"Cytokines and migraine: increase of IL-5 and IL-4 plasma levels.","volume":"38","author":"Munno","year":"1998","journal-title":"Headache"},{"key":"2022040410020858500_CIT0077","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s001090050130","article-title":"Inhibition of intercellular adhesion molecule-1 (ICAM-1), soluble ICAM-1 and interleukin-4 by nitric oxide expression in migraine patients.","volume":"75","author":"Martelletti","year":"1997","journal-title":"J Mol Med (Berl)"},{"key":"2022040410020858500_CIT0078","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4103\/aian.AIAN_371_18","article-title":"Association of serum levels of calcitonin gene-related peptide and cytokines during migraine attacks.","volume":"22","author":"Han","year":"2019","journal-title":"Ann Indian Acad Neurol"},{"key":"2022040410020858500_CIT0079","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1046\/j.1526-4610.2001.01140.x","article-title":"Immunological aspects in migraine: increase of IL-10 plasma levels during attack.","volume":"41","author":"Munno","year":"2001","journal-title":"Headache"},{"key":"2022040410020858500_CIT0080","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jneuroim.2005.10.005","article-title":"The importance of cytokines, chemokines and nitric oxide in pathophysiology of migraine.","volume":"171","author":"Fidan","year":"2006","journal-title":"J Neuroimmunol"},{"key":"2022040410020858500_CIT0081","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1359-6101(02)00025-4","article-title":"The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS).","volume":"13","author":"Beebe","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"key":"2022040410020858500_CIT0082","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0896-8411(03)00044-1","article-title":"The complex role of interleukin-10 in autoimmunity.","volume":"20","author":"Groux","year":"2003","journal-title":"J Autoimmun"},{"key":"2022040410020858500_CIT0083","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1124\/jpet.102.038703","article-title":"Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response in mice and zymosan-induced knee joint incapacitation in rats.","volume":"304","author":"Vale","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"2022040410020858500_CIT0084","doi-asserted-by":"crossref","first-page":"11701","DOI":"10.1523\/JNEUROSCI.1799-17.2017","article-title":"Autocrine interleukin-10 mediates glucagon-like peptide-1 receptor-induced spinal microglial \u03b2-endorphin expression.","volume":"37","author":"Wu","year":"2017","journal-title":"J Neurosci"},{"key":"2022040410020858500_CIT0085","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.3389\/fimmu.2019.03059","article-title":"IL-27 counteracts neuropathic pain development through induction of IL-10.","volume":"10","author":"Fonseca","year":"2019","journal-title":"Front Immunol"},{"issue":"1","key":"2022040410020858500_CIT0086","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3390\/brainsci10010030","article-title":"Calcitonin gene-related peptide (CGRP) and cluster headache.","volume":"10","author":"Carmine Belin","year":"2020","journal-title":"Brain Sci"},{"key":"2022040410020858500_CIT0087","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1526-4610.2006.00337.x","article-title":"Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally.","volume":"46","author":"Sarchielli","year":"2006","journal-title":"Headache"},{"key":"2022040410020858500_CIT0088","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1526-4610.2004.04189.x","article-title":"Chemokine levels in the jugular venous blood of migraine without aura patients during attacks.","volume":"44","author":"Sarchielli","year":"2004","journal-title":"Headache"},{"key":"2022040410020858500_CIT0089","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s12031-020-01745-y","article-title":"Differential Expression of cytokine-coding genes among migraine patients with and without aura and normal subjects.","volume":"71","author":"Taheri","year":"2021","journal-title":"J Mol Neurosci"},{"key":"2022040410020858500_CIT0090","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/j.1526-4610.2006.00722.x","article-title":"Elevation of CSF tumor necrosis factor alpha levels in new daily persistent headache and treatment refractory chronic migraine.","volume":"47","author":"Rozen","year":"2007","journal-title":"Headache"},{"key":"2022040410020858500_CIT0091","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1111\/head.12622","article-title":"CSF TNF\u03b1 has not been shown to be elevated in headache patients.","volume":"55","author":"Saxon","year":"2015","journal-title":"Headache"},{"key":"2022040410020858500_CIT0092","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.clindermatol.2003.11.006","article-title":"Pharmacology and immunology of botulinum toxin type A.","volume":"21","author":"Aoki","year":"2003","journal-title":"Clin Dermatol"},{"key":"2022040410020858500_CIT0093","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1472-8206.2008.00615.x","article-title":"Lack of anti-inflammatory effect of botulinum toxin type A in experimental models of inflammation.","volume":"22","author":"Bach-Rojecky","year":"2008","journal-title":"Fundam Clin Pharmacol"},{"key":"2022040410020858500_CIT0094","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pain.2003.10.008","article-title":"Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.","volume":"107","author":"Cui","year":"2004","journal-title":"Pain"},{"key":"2022040410020858500_CIT0095","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1097\/j.pain.0000000000000119","article-title":"OnabotulinumtoxinA decreases interictal CGRP plasma levels in patients with chronic migraine.","volume":"156","author":"Cernuda-Moroll\u00f3n","year":"2015","journal-title":"Pain"},{"key":"2022040410020858500_CIT0096","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/head.13211","article-title":"CGRP and PTX3 as predictors of efficacy of onabotulinumtoxin type A in chronic migraine: an observational study.","volume":"58","author":"Dom\u00ednguez","year":"2018","journal-title":"Headache"},{"key":"2022040410020858500_CIT0097","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1002\/JPER.19-0051","article-title":"Periodontal inflammation is related to increased serum calcitonin gene-related peptide levels in patients with chronic migraine.","volume":"90","author":"Leira","year":"2019","journal-title":"J Periodontol"},{"key":"2022040410020858500_CIT0098","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/s41598-020-80283-4","article-title":"Mild systemic inflammation enhances response to OnabotulinumtoxinA in chronic migraineurs.","volume":"11","author":"Leira","year":"2021","journal-title":"Sci Rep"},{"key":"2022040410020858500_CIT0099","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF02527632","article-title":"[Immunological abnormalities in migraine and cluster headache-epiphenomenon or pathogenetic factors?].","volume":"7","author":"Heesen","year":"1993","journal-title":"Schmerz"},{"key":"2022040410020858500_CIT0100","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1526-4610.2011.01892.x","article-title":"One hundred years of migraine research: major clinical and scientific observations from 1910 to 2010.","volume":"51","author":"Tfelt-Hansen","year":"2011","journal-title":"Headache"},{"key":"2022040410020858500_CIT0101","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1046\/j.1468-2982.1999.019008713.x","article-title":"T-cell subsets and expression of integrins in peripheral blood of patients with migraine.","volume":"19","author":"Empl","year":"1999","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0102","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1046\/j.1468-2982.1994.1402139.x","article-title":"Leukocyte subsets and cortisol serum levels in patients with migraine without aura and chronic tension-type headache.","volume":"14","author":"Leone","year":"1994","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0103","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1046\/j.1468-2982.1998.1804197.x","article-title":"Flow cytometric analysis of lymphocyte subsets in migraine patients during and outside of an acute headache attack.","volume":"18","author":"Mosnaim","year":"1998","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0104","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-2567.2008.03027.x","article-title":"CD56bright natural killer (NK) cells: an important NK cell subset.","volume":"126","author":"Poli","year":"2009","journal-title":"Immunology"},{"key":"2022040410020858500_CIT0105","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1046\/j.1468-2982.1998.1805241-5.x","article-title":"NK-mediated links for migraine.","volume":"18","author":"Martelletti","year":"1998","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0106","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1111\/j.1526-4610.2008.01136.x","article-title":"Triptan drugs, natural killer cell cytotoxicity, and neutrophils pro-matrix metalloproteinase-9 secretion.","volume":"48","author":"Puente","year":"2008","journal-title":"Headache"},{"key":"2022040410020858500_CIT0107","first-page":"131","article-title":"Peripheral blood T-lymphocyte subsets in autoimmune thyroid disease.","volume":"2","author":"Covas","year":"1992","journal-title":"J Investig Allergol Clin Immunol"},{"key":"2022040410020858500_CIT0108","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1615\/CritRevImmunol.v30.i4.10","article-title":"Role of CD8 T-cell-mediated autoimmune diseases of the central nervous system.","volume":"30","author":"Deckert","year":"2010","journal-title":"Crit Rev Immunol"},{"key":"2022040410020858500_CIT0109","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jneuroim.2015.11.015","article-title":"Reduction of CD4(+)CD25(+) regulatory T-cells in migraine: Is migraine an autoimmune disorder?","volume":"290","author":"Arumugam","year":"2016","journal-title":"J Neuroimmunol"},{"key":"2022040410020858500_CIT0110","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/jaut.2000.0473","article-title":"Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells.","volume":"16","author":"Suri-Payer","year":"2001","journal-title":"J Autoimmun"},{"key":"2022040410020858500_CIT0111","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1097\/01.tp.0000232330.46688.37","article-title":"Requirement of CD28 signaling in homeostasis\/survival of TGF-beta converted CD4+CD25+ Tregs from thymic CD4+CD25- single positive T cells.","volume":"82","author":"Liu","year":"2006","journal-title":"Transplantation"},{"key":"2022040410020858500_CIT0112","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1365-2133.2005.06675.x","article-title":"Relative impact of CD4+CD25+ regulatory T cells and tacrolimus on inhibition of T-cell proliferation in patients with atopic dermatitis.","volume":"153","author":"Vukmanovic-Stejic","year":"2005","journal-title":"Br J Dermatol"},{"key":"2022040410020858500_CIT0113","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1046\/j.1440-1711.2002.01127.x","article-title":"The role of CD4+CD25+ immunoregulatory T cells in the induction of autoimmune gastritis.","volume":"80","author":"Laurie","year":"2002","journal-title":"Immunol Cell Biol"},{"key":"2022040410020858500_CIT0114","doi-asserted-by":"crossref","first-page":"7135","DOI":"10.4049\/jimmunol.175.11.7135","article-title":"CD4+CD25+ T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells.","volume":"175","author":"DiPaolo","year":"2005","journal-title":"J Immunol"},{"key":"2022040410020858500_CIT0115","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.2337\/db08-1504","article-title":"CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells.","volume":"58","author":"Mari\u00f1o","year":"2009","journal-title":"Diabetes"},{"key":"2022040410020858500_CIT0116","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1034\/j.1600-065X.2001.1820102.x","article-title":"Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance.","volume":"182","author":"Sakaguchi","year":"2001","journal-title":"Immunol Rev"},{"key":"2022040410020858500_CIT0117","first-page":"1","article-title":"Reduced regulatory T lymphocytes in migraine patients","author":"Faraji","year":"2021","journal-title":"Neurol Res"},{"key":"2022040410020858500_CIT0118","doi-asserted-by":"crossref","first-page":"12277","DOI":"10.1038\/s41598-020-69285-4","article-title":"The role of the immune system and the biomarker CD3\u2009+\u2009CD4\u2009+\u2009CD45RA-CD62L- in the pathophysiology of migraine.","volume":"10","author":"Pavelek","year":"2020","journal-title":"Sci Rep"},{"key":"2022040410020858500_CIT0119","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1526-4610.1984.hed2403152.x","article-title":"HLA-B14 antigen in cluster headache.","volume":"24","author":"Martelletti","year":"1984","journal-title":"Headache"},{"key":"2022040410020858500_CIT0120","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1526-4610.1987.hed2701035.x","article-title":"Variations in the Leu7+ and LeuM3+ leukocyte subpopulations observed in cluster headache are dependent on HLA-DR antigens.","volume":"27","author":"Giacovazzo","year":"1987","journal-title":"Headache"},{"key":"2022040410020858500_CIT0121","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1046\/j.1468-2982.1993.1305343.x","article-title":"Serum interleukin-1 beta is increased in cluster headache.","volume":"13","author":"Martelletti","year":"1993","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0122","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1526-4610.2003.03011.x","article-title":"Soluble interleukin-2 receptors increase during the active periods in cluster headache.","volume":"43","author":"Empl","year":"2003","journal-title":"Headache"},{"key":"2022040410020858500_CIT0123","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1600-0404.2010.01434.x","article-title":"Interleukin-2 gene expression in different phases of episodic cluster headache\u2013a pilot study.","volume":"124","author":"Steinberg","year":"2011","journal-title":"Acta Neurol Scand"},{"key":"2022040410020858500_CIT0124","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/0333102414539057","article-title":"Corticosteroids alter CGRP and melatonin release in cluster headache episodes.","volume":"35","author":"Neeb","year":"2015","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0125","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s10194-016-0609-x","article-title":"Methylprednisolone blocks interleukin 1 beta induced calcitonin gene related peptide release in trigeminal ganglia cells.","volume":"17","author":"Neeb","year":"2016","journal-title":"J Headache Pain"},{"key":"2022040410020858500_CIT0126","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1177\/0333102414559734","article-title":"Increased serum levels of interleukin-8 in patients with tension-type headache.","volume":"35","author":"Domingues","year":"2015","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0127","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1155\/2013\/796161","article-title":"Peripheral interleukin-1\u00df levels are elevated in chronic tension-type headache patients.","volume":"18","author":"Della Vedova","year":"2013","journal-title":"Pain Res Manag"},{"key":"2022040410020858500_CIT0128","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s10072-019-04151-4","article-title":"Salivary inflammatory markers in tension type headache and migraine: the SalHead cohort study.","volume":"41","author":"Bougea","year":"2020","journal-title":"Neurol Sci"},{"key":"2022040410020858500_CIT0129","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1468-2982.2008.01727.x","article-title":"Cerebrospinal fluid cytokine levels in migraine, tension-type headache and cervicogenic headache.","volume":"29","author":"B\u00f8","year":"2009","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0130","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1177\/0333102418771350","article-title":"Current understanding of meningeal and cerebral vascular function underlying migraine headache.","volume":"39","author":"Levy","year":"2019","journal-title":"Cephalalgia"},{"key":"2022040410020858500_CIT0131","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s11916-014-0464-x","article-title":"What is the evidence for the use of corticosteroids in migraine?","volume":"18","author":"Woldeamanuel","year":"2014","journal-title":"Curr Pain Headache Rep"},{"key":"2022040410020858500_CIT0132","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2377-13-99","article-title":"Study protocol of Prednisone in episodic Cluster Headache (PredCH): a randomized, double-blind, placebo-controlled parallel group trial to evaluate the efficacy and safety of oral prednisone as an add-on therapy in the prophylactic treatment of episodic cluster headache with verapamil.","volume":"13","author":"Holle","year":"2013","journal-title":"BMC Neurol"},{"key":"2022040410020858500_CIT0133","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1474-4422(20)30363-X","article-title":"Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial.","volume":"20","author":"Obermann","year":"2021","journal-title":"Lancet Neurol"},{"key":"2022040410020858500_CIT0134","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1474-4422(20)30402-6","article-title":"Oral steroids for episodic cluster headache.","volume":"20","author":"Ducros","year":"2021","journal-title":"Lancet Neurol"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cei\/advance-article-pdf\/doi\/10.1093\/cei\/uxab025\/42293233\/uxab025.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/207\/1\/11\/43249284\/uxab025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/207\/1\/11\/43249284\/uxab025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T10:09:05Z","timestamp":1649066945000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/207\/1\/11\/6445010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,27]]},"references-count":134,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,11,27]]},"published-print":{"date-parts":[[2022,1,28]]}},"URL":"https:\/\/doi.org\/10.1093\/cei\/uxab025","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2021,11,27]]}}}