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The imbalance or dysregulation of chemokines has contributed to the development of several diseases, especially cancer. CCL19 is one of the homeostatic chemokines that is abundantly expressed in the thymus and lymph nodes. This chemokine, which primarily regulates immune cell trafficking, is involved in cancer development. Through the induction of anti-tumor immune responses and inhibition of angiogenesis, CCL19 exerts tumor-suppressive functions. In contrast, CCL19 also acts as a tumor-supportive factor by inducing inflammation, cell growth, and metastasis. Moreover, CCL19 dysregulation in several cancers, including colorectal, breast, pancreatic, and lung cancers, has been considered a tumor biomarker for diagnosis and prognosis. Using CCL19-based therapeutic approaches has also been proposed to overcome cancer development. This review will shed more light on the multifarious function of CCL19 in cancer and elucidate its application in diagnosis, prognosis, and even therapy. It is expected that the study of CCL19 in cancer might be promising to broaden our knowledge of cancer development and might introduce novel approaches in cancer management.<\/jats:p>","DOI":"10.1093\/cei\/uxab039","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T13:53:10Z","timestamp":1641995590000},"page":"164-175","source":"Crossref","is-referenced-by-count":67,"title":["Does CCL19 act as a double-edged sword in cancer development?"],"prefix":"10.1093","volume":"207","author":[{"given":"Arezoo","family":"Gowhari Shabgah","sequence":"first","affiliation":[{"name":"School of Medicine, Bam University of Medical Sciences, Bam, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid Mahdi Jaber","family":"Al-Obaidi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, University of Alkafeel, Najaf, Iraq"},{"name":"Department of Chemistry and Biochemistry, College of Medicine, University of Kerbala, Karbala, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heshu","family":"Sulaiman Rahman","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine, University of Sulaimani, Sulaimaniyah, Iraq"},{"name":"Department of Medical Laboratory Sciences, Komar University of Science and Technology, Sulaimaniyah, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Kamal Abdelbasset","sequence":"additional","affiliation":[{"name":"Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia"},{"name":"Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanich","family":"Suksatan","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry O","family":"Bokov","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation"},{"name":"Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Thangavelu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha institute of medical and Technical Sciences, Saveetha University, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abduladheem","family":"Turki Jalil","sequence":"additional","affiliation":[{"name":"Faculty of Biology and Ecology, Yanka Kupala State University of Grodno, Grodno, Belarus"},{"name":"College of Technical 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