{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:16:27Z","timestamp":1787008587570,"version":"build-2736575974"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endometriosis is a chronic inflammatory disorder resulting in pelvic pain and infertility. The role of T helper 17 (Th17) cells in endometriosis remains elusive. In this study, through detecting CXCR3, CCR4, CCR10, CCR6, interleukin-17 Receptor E (IL-17RE), and CD27, ROR\u03b3t-and-IL-17A-expressing Th17 cells were distinguished and sorted from peritoneal fluid (PF) of patients with stage III and IV endometriosis. Furthermore, we found that IL-17RE and CD27 were the labels of heterogeneous PF Th17 subsets, i.e. IL-17RE-CD27\u2212 subset, IL-17RE+CD27- subset, and IL-17RE+CD27+ subset. The former two subsets expressed higher IL-17A, GM-CSF, and IL-22 and were more proliferative than the latter subset. RNA-Seq analysis on IL-17RE+ Th17 subset and IL-17RE- Th17 subset revealed up-regulation of genes involved in oxidative phosphorylation and electron transport chain in IL-17RE+ Th17 subset relative to IL-17RE\u2212 Th17 subset. Consistently, the IL-17RE+ Th17 subset produced more adenosine triphosphate (ATP) and reactive oxygen species (ROS) than IL-17RE\u2212 Th17 subset. In conclusion, this study provides a novel method to detect and isolate live PF Th17 cells from endometriosis patients and unveils the functional and metabolic heterogeneity of PF Th17 subsets. Therefore, it sheds light on the elucidation of molecular mechanisms that modulate the function of pathological Th17 cells in endometriosis.<\/jats:p>","DOI":"10.1093\/cei\/uxac004","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T11:41:29Z","timestamp":1643370089000},"page":"360-369","source":"Crossref","is-referenced-by-count":8,"title":["Interleukin 17 receptor E identifies heterogeneous T helper 17 cells in peritoneal fluid of moderate and severe endometriosis patients"],"prefix":"10.1093","volume":"207","author":[{"given":"Yanping","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Gynaecology, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-7560","authenticated-orcid":false,"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Qin","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aili","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR 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