{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:03:58Z","timestamp":1785240238835,"version":"3.55.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z171100001017098"],"award-info":[{"award-number":["Z171100001017098"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670166"],"award-info":[{"award-number":["81670166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870140"],"award-info":[{"award-number":["81870140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070184"],"award-info":[{"award-number":["82070184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370666"],"award-info":[{"award-number":["81370666"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Peking University People\u2019s Hospital Research and Development Funds","award":["RDX2019-14"],"award-info":[{"award-number":["RDX2019-14"]}]},{"name":"Peking University People\u2019s Hospital Research and Development Funds","award":["RDL2021-01"],"award-info":[{"award-number":["RDL2021-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cytomegalovirus (CMV) infection and acute graft-versus-host disease (aGVHD) are two major complications that contribute to a poor prognosis after hematopoietic stem cell transplantation (HSCT). Superior early immune reconstitution (IR) is associated with improved survival after HSCT. However, when all three factors, CMV infection, aGVHD, and IR, are concomitantly considered, the effects of the triple events on HSCT are still unknown and should be studied further. Thus we enrolled 185 patients who were diagnosed as hematological malignancies and treated with HLA-matched sibling transplantation (MST) between January 2010 and December 2014, of whom 83 were positive for CMV infection and 82 had aGVHD. Results showed that patients with both aGVHD and CMV infection had significantly higher non-relapse mortality (NRM), lower overall survival (OS), and delayed CD8+ T-cell IR. Multivariate analyses showed that both aGVHD combined with CMV infection and delayed CD8+ T-cell IR were independent risk factors for prognosis post-MST. Recurrent CMV infections are associated with poor CD8+ T-cell reconstitution. However, superior IR could protect against the negative effects of aGVHD and CMV infection on the transplant outcomes.<\/jats:p>","DOI":"10.1093\/cei\/uxac047","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T17:16:38Z","timestamp":1652375798000},"page":"332-339","source":"Crossref","is-referenced-by-count":21,"title":["CMV infection combined with acute GVHD associated with poor CD8+ T-cell immune reconstitution and poor prognosis post-HLA-matched allo-HSCT"],"prefix":"10.1093","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9700-1867","authenticated-orcid":false,"given":"Ze-Ying","family":"Fan","sequence":"first","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Han","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zuo","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Su","family":"Zhao","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Jun","family":"Chang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Lv","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Mo","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qian","family":"Sun","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan-Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8139-1773","authenticated-orcid":false,"given":"Xiang-Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation , Beijing 100044 , China"},{"name":"Collaborative Innovation Center of Hematology , Beijing 100044 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"2022062403302422300_CIT0001","doi-asserted-by":"crossref","first-page":"e620","DOI":"10.1093\/cid\/ciaa1871","article-title":"Effect of cytomegalovirus reactivation with or without acute graft-versus-host disease on the risk of nonrelapse mortality [J].","volume":"73","author":"Akahoshi","year":"2021","journal-title":"Clin Infect Dis"},{"key":"2022062403302422300_CIT0002","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1182\/blood-2015-11-679639","article-title":"Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis [J].","volume":"127","author":"Teira","year":"2016","journal-title":"Blood"},{"key":"2022062403302422300_CIT0003","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/ajh.26094","article-title":"Cytomegalovirus kinetics after hematopoietic cell transplantation reveal peak titers with differential impact on mortality, relapse and immune reconstitution [J].","volume":"96","author":"Leserer","year":"2021","journal-title":"Am J Hematol"},{"key":"2022062403302422300_CIT0004","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13287-020-01615-9","article-title":"Tumor necrosis factor alpha in aGVHD patients contributed to the impairment of recipient bone marrow MSC stemness and deficiency of their hematopoiesis-promotion capacity [J].","volume":"11","author":"Ding","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"2022062403302422300_CIT0005","doi-asserted-by":"crossref","first-page":"7165230","DOI":"10.1155\/2020\/7165230","article-title":"HMGB1 recruits TET2\/AID\/TDG to induce DNA demethylation in STAT3 promoter in CD4(+) T cells from aGVHD patients [J].","volume":"2020","author":"Xu","year":"2020","journal-title":"J Immunol Res"},{"key":"2022062403302422300_CIT0006","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/ctr.12771","article-title":"Early lymphocyte recovery predicts superior outcomes after unmanipulated haploidentical blood and marrow transplant for acute myeloid leukemia [J].","volume":"30","author":"Fu","year":"2016","journal-title":"Clin Transplant"},{"key":"2022062403302422300_CIT0007","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jcyt.2020.05.005","article-title":"Early CD4+ T cell reconstitution as predictor of outcomes after allogeneic hematopoietic cell transplantation [J].","volume":"22","author":"Van Roessel","year":"2020","journal-title":"Cytotherapy"},{"key":"2022062403302422300_CIT0008","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1080\/10428194.2016.1265113","article-title":"Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant [J].","volume":"58","author":"Goldberg","year":"2017","journal-title":"Leuk Lymphoma"},{"key":"2022062403302422300_CIT0009","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbmt.2019.09.028","article-title":"Impact of cytomegalovirus reactivation and natural killer reconstitution on outcomes after allogeneic hematopoietic stem cell transplantation: a single-center analysis [J].","volume":"26","author":"Ando","year":"2020","journal-title":"Biol Blood Marrow Transplant"},{"key":"2022062403302422300_CIT0010","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1126\/science.aav9867","article-title":"B cells, CMV, and stem cell transplant [J].","volume":"363","author":"Alegre","year":"2019","journal-title":"Science"},{"key":"2022062403302422300_CIT0011","doi-asserted-by":"crossref","first-page":"782","DOI":"10.3389\/fimmu.2019.00782","article-title":"B cell reconstitution and influencing factors after hematopoietic stem cell transplantation in children [J].","volume":"10","author":"Van Der Maas","year":"2019","journal-title":"Front Immunol"},{"key":"2022062403302422300_CIT0012","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1182\/blood-2015-01-622837","article-title":"Acute GVHD results in a severe DC defect that prevents T-cell priming and leads to fulminant cytomegalovirus disease in mice [J].","volume":"126","author":"Wikstrom","year":"2015","journal-title":"Blood"},{"key":"2022062403302422300_CIT0013","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.retram.2019.01.001","article-title":"HLA-DP mismatch and CMV reactivation increase risk of aGVHD independently in recipients of allogeneic stem cell transplant [J].","volume":"67","author":"Ghobadi","year":"2019","journal-title":"Curr Res Transl Med"},{"key":"2022062403302422300_CIT0014","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jcyt.2020.01.005","article-title":"Rapid reconstitution of regulatory T-cell subsets is associated with reduced rates of acute graft-versus-host disease and absence of viremia after cord blood transplantation in children with reduced-intensity conditioning using alemtuzumab [J].","volume":"22","author":"Chen","year":"2020","journal-title":"Cytotherapy"},{"key":"2022062403302422300_CIT0015","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/bjh.14622","article-title":"Recipient-donor KIR ligand matching prevents CMV reactivation post-haploidentical T cell-replete transplantation [J].","volume":"177","author":"Zhao","year":"2017","journal-title":"Brit J Haematol"},{"key":"2022062403302422300_CIT0016","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s10875-011-9630-7","article-title":"Immune reconstitution following unmanipulated HLA-mismatched\/haploidentical transplantation compared with HLA-identical sibling transplantation [J].","volume":"32","author":"Chang","year":"2012","journal-title":"J Clin Immunol"},{"key":"2022062403302422300_CIT0017","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1182\/blood-2015-03-631853","article-title":"CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRbeta repertoire [J].","volume":"125","author":"Suessmuth","year":"2015","journal-title":"Blood"},{"key":"2022062403302422300_CIT0018","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1053\/j.seminhematol.2019.03.005","article-title":"Immune reconstitution after T-cell replete HLA-haploidentical transplantation [J].","volume":"56","author":"Mccurdy","year":"2019","journal-title":"Semin Hematol"},{"key":"2022062403302422300_CIT0019","doi-asserted-by":"crossref","first-page":"E585","DOI":"10.1016\/S2352-3026(19)30154-1","article-title":"Effect of donor type and conditioning regimen intensity on allogeneic transplantation outcomes in patients with sickle cell disease: a retrospective multicentre, cohort study [J].","volume":"6","author":"Eapen","year":"2019","journal-title":"Lancet Haematol"},{"key":"2022062403302422300_CIT0020","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/s41423-020-00597-1","article-title":"Dynamic immune profiling identifies the stronger graft-versus-leukemia (GVL) effects with haploidentical allografts compared to HLA-matched stem cell transplantation [J].","volume":"18","author":"Guo","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"2022062403302422300_CIT0021","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1182\/blood-2016-06-724005","article-title":"Strategies before, during, and after hematopoietic cell transplantation to improve T-cell immune reconstitution [J].","volume":"128","author":"De Koning","year":"2016","journal-title":"Blood"},{"key":"2022062403302422300_CIT0022","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1182\/blood-2002-11-3472","article-title":"Immune reconstitution to cytomegalovirus after allogeneic hematopoietic stem cell transplantation: impact of host factors, drug therapy, and subclinical reactivation [J].","volume":"102","author":"Hakki","year":"2003","journal-title":"Blood"},{"key":"2022062403302422300_CIT0023","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/bmt.2016.116","article-title":"Leukemia-free survival in myeloid leukemia, but not in lymphoid leukemia, is predicted by early CD4+ reconstitution following unrelated cord blood transplantation in children: a multicenter retrospective cohort analysis [J].","volume":"51","author":"Admiraal","year":"2016","journal-title":"Bone Marrow Transplant"},{"key":"2022062403302422300_CIT0024","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1182\/blood-2016-06-721936","article-title":"Excellent T-cell reconstitution and survival depend on low ATG exposure after pediatric cord blood transplantation [J].","volume":"128","author":"Admiraal","year":"2016","journal-title":"Blood"},{"key":"2022062403302422300_CIT0025","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbmt.2012.10.010","article-title":"Immune reconstitution kinetics as an early predictor for mortality using various hematopoietic stem cell sources in children [J].","volume":"19","author":"Bartelink","year":"2013","journal-title":"Biol Blood Marrow Tr"},{"key":"2022062403302422300_CIT0026","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/j.jaci.2016.12.992","article-title":"Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation [J].","volume":"140","author":"Admiraal","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2022062403302422300_CIT0027","doi-asserted-by":"crossref","first-page":"E194","DOI":"10.1016\/S2352-3026(15)00045-9","article-title":"Association between anti-thymocyte globulin exposure and CD4(+) immune reconstitution in paediatric haemopoietic cell transplantation: a multicentre, retrospective pharmacodynamic cohort analysis [J].","volume":"2","author":"Admiraal","year":"2015","journal-title":"Lancet Haematol"},{"key":"2022062403302422300_CIT0028","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1182\/blood-2012-09-453720","article-title":"Cytomegalovirus-specific T cells are primed early after cord blood transplant but fail to control virus in vivo [J].","volume":"121","author":"Mcgoldrick","year":"2013","journal-title":"Blood"},{"key":"2022062403302422300_CIT0029","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41423-021-00829-y","article-title":"Comparable anti-CMV responses of transplant donor and third-party CMV-specific T cells for treatment of CMV infection after allogeneic stem cell transplantation [J].","volume":"19","author":"Pei","year":"2022","journal-title":"Cell Mol Immunol"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cei\/advance-article-pdf\/doi\/10.1093\/cei\/uxac047\/43899805\/uxac047.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/208\/3\/332\/44234999\/uxac047.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/208\/3\/332\/44234999\/uxac047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T03:30:54Z","timestamp":1656041454000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/208\/3\/332\/6585019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,12]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,5,12]]},"published-print":{"date-parts":[[2022,6,23]]}},"URL":"https:\/\/doi.org\/10.1093\/cei\/uxac047","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,6,1]]},"published":{"date-parts":[[2022,5,12]]}}}