{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:02:51Z","timestamp":1783476171849,"version":"3.55.0"},"reference-count":95,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,29]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Allergic respiratory diseases (ARDs) are still a major burden on global public health. Sublingual immunotherapy (SLIT) is a mode of allergen immunotherapy (AIT) which involves administration of the allergen under the tongue, and benefits from tolerogenic properties of the oral mucosa. Studies revealed reduced levels of eosinophilia and eosinophil-dominated inflammation in airways of both animals and humans after SLIT. SLIT was also suggested to lower basophil responsiveness and innate lymphoid cell-2 function in blood samples collected from patients with ARD. Moreover, apart from shifting pathogenic type 2 (TH2) to a type 1 (TH1) and protective regulatory (Treg) polarization of helper T-cell immune response, antibody isotype switch from IgE to IgG1, IgG2, IgG4 and IgA was also reported in patients with ARD receiving SLIT. Today, the literature on SLIT-mediated activities is still scarce and more studies are required to further enlighten the mechanisms utilized by SLIT for the induction of tolerance. The aim of this review is to summarize the current knowledge about the immune-regulatory mechanisms induced by SLIT against ARDs.<\/jats:p>","DOI":"10.1093\/cei\/uxac075","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T12:17:43Z","timestamp":1660738663000},"page":"262-269","source":"Crossref","is-referenced-by-count":7,"title":["Immune mechanisms induced by sublingual immunotherapy in allergic respiratory diseases"],"prefix":"10.1093","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-478X","authenticated-orcid":false,"given":"Umut","family":"Gazi","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Clinical Microbiology, Faculty of Medicine, Near East University , Nicosia , Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1337-2041","authenticated-orcid":false,"given":"Nerin Nadir","family":"Bahceciler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Allergy and Immunology, Faculty of Medicine, Near East University , Nicosia , Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"2023012105200152900_CIT0001","volume-title":"The Global Impact of Respiratory Disease","author":"Marciniuk","year":"2017","edition":"2nd edn"},{"key":"2023012105200152900_CIT0002","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S2213-2600(20)30105-3","article-title":"Prevalence and attributable health burden of chronic respiratory diseases, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"8","author":"Soriano","year":"2020","journal-title":"Lancet Respir 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