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With their distinct transcriptomes, growth-factor dependencies and T-cell receptor (TCR) repertoires, Tregs in nonlymphoid tissues, termed \u201ctissue-Tregs,\u201d also perform a variety of functions to help assure tissue homeostasis. For example, they are important for tissue repair and regeneration after various types of injury, both acute and chronic. They exert this influence by controlling both the inflammatory tenor and the dynamics of the parenchymal progenitor-cell pool in injured tissues, thereby promoting efficient repair and limiting fibrosis. Thus, tissue-Tregs are seemingly attractive targets for immunotherapy in the context of tissue regeneration, offering several advantages over existing therapies. Using skeletal muscle as a model system, we discuss the existing literature on Tregs\u2019 role in tissue regeneration in acute and chronic injuries, and various approaches for their therapeutic modulation in such contexts, including exercise as a natural Treg modulator.<\/jats:p>","DOI":"10.1093\/cei\/uxac076","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T17:17:31Z","timestamp":1660670251000},"page":"138-148","source":"Crossref","is-referenced-by-count":14,"title":["The potential for Treg-enhancing therapies in tissue, in particular skeletal muscle, regeneration"],"prefix":"10.1093","volume":"211","author":[{"given":"Bola S","family":"Hanna","sequence":"first","affiliation":[{"name":"Department of Immunology, Harvard Medical School and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women\u2019s Hospital ; Boston , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar K","family":"Yaghi","sequence":"additional","affiliation":[{"name":"Department of Immunology, Harvard Medical School and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women\u2019s Hospital ; Boston , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6655-1911","authenticated-orcid":false,"given":"P Kent","family":"Langston","sequence":"additional","affiliation":[{"name":"Department of Immunology, Harvard Medical School and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women\u2019s Hospital ; Boston , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6110-4626","authenticated-orcid":false,"given":"Diane","family":"Mathis","sequence":"additional","affiliation":[{"name":"Department of Immunology, Harvard Medical School and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women\u2019s 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