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In this study, a pregnant mouse model with high serum alpha-enolase (ENO1)-specific antibody (ENO1Ab) was established by immunization with ENO1 protein to explore the effects of maternal circulatory ENO1Ab on the brain development in offspring. The pups showed impaired learning and memory abilities with obviously thinner tight junctions in the brain tissue. IgG deposits colocalized with both ENO1 protein and complement 3 (C3), and the membrane attack complex was obviously detectable in the brain tissues of pups from dams with high serum ENO1Ab expression. Our findings suggest that highly expressed ENO1Ab in the maternal circulation can pass through the blood-placenta-barrier and the compromised blood-brain barrier into the brain tissues of offspring and may cause neurological development impairment mainly through complement-dependent cytotoxicity.<\/jats:p>","DOI":"10.1093\/cei\/uxac086","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T18:54:33Z","timestamp":1663959273000},"page":"187-198","source":"Crossref","is-referenced-by-count":3,"title":["The effects of maternal anti-alpha-enolase antibody expression on the brain development in offspring"],"prefix":"10.1093","volume":"210","author":[{"given":"Wei","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang 110001 , PR 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