{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:12:16Z","timestamp":1781712736236,"version":"3.54.5"},"reference-count":135,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,31]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Autoinflammatory diseases represent a family of immune-mediated conditions characterized by the unchecked activation of innate immunity. These conditions share common clinical features such as recurrent fever, inflammatory arthritis, and elevation of acute phase reactants, in the absence of an identified infectious etiology, generally without detectable serum autoantibodies, with variable response to glucocorticoids and in some cases colchicine, which represented the mainstay of treatment until cytokine blockade therapies became available. The first autoinflammatory diseases to be described were monogenic disorders caused by missense mutations in inflammasome components and were recognized predominantly during childhood or early adulthood. However, the progress of genetic analyses and a more detailed immunological phenotyping capacity led to the discovery a wide spectrum of diseases, often becoming manifest or being diagnosed in the adult population. The beneficial role of targeting hyperinflammation via interleukin 1 in complex non-immune-mediated diseases is a field of growing clinical interest. We provide an overview of the autoinflammatory diseases of interest to physicians treating adult patients and to analyze the contribution of hyperinflammation in non-immune-mediated diseases; the result is intended to provide a roadmap to orient scientists and clinicians in this broad area.<\/jats:p>","DOI":"10.1093\/cei\/uxac098","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T12:47:58Z","timestamp":1667652478000},"page":"295-308","source":"Crossref","is-referenced-by-count":12,"title":["Autoinflammatory manifestations in adult patients"],"prefix":"10.1093","volume":"210","author":[{"given":"Stefano","family":"Rodolfi","sequence":"first","affiliation":[{"name":"Rheumatology and Clinical Immunology IRCCS Humanitas Research Hospital , Rozzano, Milan , Italy"},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Nasone","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan , Italy"},{"name":"Emergency Department, IRCCS Humanitas Research Hospital , Rozzano, Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Folci","sequence":"additional","affiliation":[{"name":"Nephrology and Internal Medicine, IRCCS Humanitas Research Hospital , Rozzano, Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0323-0376","authenticated-orcid":false,"given":"Carlo","family":"Selmi","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology IRCCS Humanitas Research Hospital , Rozzano, Milan , Italy"},{"name":"Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Brunetta","sequence":"additional","affiliation":[{"name":"Nephrology and Internal Medicine, IRCCS Humanitas Research Hospital , Rozzano, Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"issue":"1","key":"2023030412104275100_","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0092-8674(00)80721-7","article-title":"Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.","volume":"97","author":"McDermott","year":"1999","journal-title":"Cell"},{"issue":"1","key":"2023030412104275100_","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.autrev.2012.07.015","article-title":"The diagnostic evaluation of patients with potential adult-onset autoinflammatory disorders: Our experience and 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