{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:01:53Z","timestamp":1779174113996,"version":"3.51.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81621001"],"award-info":[{"award-number":["81621001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870140"],"award-info":[{"award-number":["81870140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070184"],"award-info":[{"award-number":["82070184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z211100002921071"],"award-info":[{"award-number":["Z211100002921071"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Peking University People\u2019s Hospital Research and Development Funds","award":["RDX2019-36"],"award-info":[{"award-number":["RDX2019-36"]}]},{"name":"Peking University People\u2019s Hospital Research and Development Funds","award":["RDL2021-01"],"award-info":[{"award-number":["RDL2021-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The effect of cytomegalovirus (CMV) infection on leukemia relapse and the potential mechanism remains controversial. In this retrospective study, we evaluated the association among CMV infection, NK reconstitution and clinical outcomes in consecutive patients with hematologic malignancy who underwent HLA matched sibling donor transplantation (MST). In total, 228 patients were enrolled in the study between January 2010 and December 2011. The cumulative incidence of CMV infection on day 100 post-HSCT was 13.6 \u00b1 4.9%. The probabilities of OS and DFS were 45.4% vs. 71.7% (P = 0.004) and 43.9% vs. 64.2% (P = 0.050) in the patients with CMV infection and without CMV infection, respectively. The cumulative incidence of treatment-related mortality (TRM) and relapse at 5 years was 48.6 \u00b1 9.6% vs. 11.5 \u00b1 2.9% (P &amp;lt; 0.001) and 6.2 \u00b1 4.3% vs. 29.2 \u00b1 3.9% (P = 0.024) in the patients with CMV infection and without CMV infection, respectively. In the multivariate analysis, CMV infection was associated with higher TRM, lower OS, and lower DFS. In addition, we found that CMV infection may promote the recovery of the absolute number of NK cells and promote the differentiation of NK cells post-MST. In conclusion, CMV infection may promote the recovery and differentiation of NK cells and was correlated with a lower relapse rate post-MST.<\/jats:p>","DOI":"10.1093\/cei\/uxac099","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T16:09:38Z","timestamp":1668614978000},"page":"283-294","source":"Crossref","is-referenced-by-count":1,"title":["Cytomegalovirus infection is associated with rapid NK differentiation and reduced incidence of relapse in HLA matched sibling donor transplant patients"],"prefix":"10.1093","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5047-9249","authenticated-orcid":false,"given":"Tingting","family":"Han","sequence":"first","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease , No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Xie","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease , No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaosu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease , No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Lv","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease , No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjun","family":"Chang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease , No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanping","family":"Xu","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease , No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease , No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease , No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease , No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease , No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8139-1773","authenticated-orcid":false,"given":"Xiang-Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease , No. 11 South Street of Xizhimen, Xicheng District, Beijing 100044 , China"},{"name":"Collaborative Innovation Center of Hematology , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"2023081113334279700_CIT0001","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1586\/17474086.2014.954543","article-title":"Haploidentical stem cell transplantation for the treatment of leukemia: current 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