{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:14:55Z","timestamp":1772838895647,"version":"3.50.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"High-level talent introduction plan","award":["C1034211"],"award-info":[{"award-number":["C1034211"]}]},{"name":"High-level talent introduction plan","award":["C1051004"],"award-info":[{"award-number":["C1051004"]}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Psoriasis is a genetically determined, environmentally triggered, immune system-mediated autoimmune disease. Different animal models are needed to investigate the complex pathological mechanisms underlying this disease. Therefore, we established mannan-induced psoriasis model and compared with the most commonly used imiquimod-induced psoriasis in terms of disease, induction of innate immune cells, expression of cytokines, and the effect of dexamethasone treatment. Mannan significantly induced more severe psoriasis with better disease relapsing feature than imiquimod (IMQ). As determined by immunohistochemistry, IMQ induced significantly more infiltration of CD11c+ and F4\/80+ cells than mannan in the skin. However, cytometric analysis showed a significant increase in the percentage of Gr-1+ neutrophils in the spleen and lymph nodes as well as F4\/80+ macrophages in the spleen after mannan exposure. Variation in the percentage of significantly increased V\u03b34 T cells was also found to be dependent on the lymphoid organs tested. However, there is a clear difference between these models in terms of expression of certain cytokine genes: IL-22, IL-23, IL-17E, and IL-17F were expressed more predominantly in mannan-induced inflammation, while IL-6 and IL-17A expressions were significantly higher in IMQ model. Interestingly, dexamethasone treatment strongly reduced epidermal thickness and histological scores induced by mannan than IMQ. Despite inducing psoriasis-like inflammation, certain differences and similarities were observed in the immune responses induced by mannan and IMQ. However, mannan-induced psoriasis model is relatively more simple, economical and less harmful to mice with an increased possibility to develop a chronic psoriasis model by exposing mice to mannan.<\/jats:p>","DOI":"10.1093\/cei\/uxad004","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T12:57:21Z","timestamp":1673873841000},"page":"288-300","source":"Crossref","is-referenced-by-count":15,"title":["Comparative studies on mannan and imiquimod induced experimental plaque psoriasis inflammation in inbred mice"],"prefix":"10.1093","volume":"211","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9049-7027","authenticated-orcid":false,"given":"Huimei","family":"Wu","sequence":"first","affiliation":[{"name":"Southern Medical University\u2014Karolinska Institute United Medical Inflammation Center, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou , China"},{"name":"School of medicine, Southern University of Science and Technology , Shenzhen , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxin","family":"Ou","sequence":"additional","affiliation":[{"name":"Southern Medical University\u2014Karolinska Institute United Medical Inflammation Center, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou , China"},{"name":"Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangxin","family":"Li","sequence":"additional","affiliation":[{"name":"Southern Medical University\u2014Karolinska Institute United Medical Inflammation Center, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou , China"},{"name":"Department of Endocrinology, Fifth Affiliated Hospital, Southern Medical University , Guangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[{"name":"Southern Medical University\u2014Karolinska Institute United Medical Inflammation Center, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou , China"},{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7790-8197","authenticated-orcid":false,"given":"Kutty Selva","family":"Nandakumar","sequence":"additional","affiliation":[{"name":"Southern Medical University\u2014Karolinska Institute United Medical Inflammation Center, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou , China"},{"name":"Department of Environmental and Biosciences, School of Business, Innovation and 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