{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:33:57Z","timestamp":1787643237694,"version":"build-2736575974"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T00:00:00Z","timestamp":1675987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DEQ20150934719"],"award-info":[{"award-number":["DEQ20150934719"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007486","name":"Universit\u00e9 Paris-Sud","doi-asserted-by":"publisher","award":["UPSud\/SAIC N 97731"],"award-info":[{"award-number":["UPSud\/SAIC N 97731"]}],"id":[{"id":"10.13039\/501100007486","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovative Medicines Initiative 2 Joint Undertaking","award":["806975"],"award-info":[{"award-number":["806975"]}]},{"name":"EU H2020","award":["H2020-SC1-2016-RTD\/731944"],"award-info":[{"award-number":["H2020-SC1-2016-RTD\/731944"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Salivary gland epithelial cells (SGECs) play an active role in primary Sjogren\u2019s syndrome (pSS) pathogenesis. Quantitative and qualitative abnormalities of saliva might expose SGECs to chronic hyperosmolarity. We aimed to decipher the links between hyperosmolar stimulation of SGECs and lymphocytic infiltration of the salivary glands (SG) observed in pSS. RNAseq was performed on NS-SV-AC cells stimulated with hyperosmolar media containing NaCl (100 mM) or sucrose (200 mM), or with iso-osmolar (Iso) medium. RNAseq was performed on primary cultured SGECs from pSS and controls, in the presence or not of B cells. Hyperosmolar stimulation of NS-SV-AC-cells identified an upregulation of interferon-induced (MX1, IFIT2) and MMPs genes. Enrichment analysis revealed an over-representation of fibrosis pathway. In parallel, RNAseq of SGECs comparing pSS to controls identified an over-representation of a pathway involving MMPs. Given the unexpected upregulation of collagen (COL3A1, COL1A2) and ADAMTS genes in pSS SGECs, we hypothesized that SGECs might undergo epithelial\u2013mesenchymal transition. ZEB2 was upregulated and SLUG was down regulated in SGECs from pSS versus controls. MMP24 and ZEB2 were higher in SGECs from pSS with a focus score \u22651 versus &amp;lt;1. Lastly, SGECs cocultured with B cells expressed higher levels of COL1A2. These results suggest the existence of a vicious circle. Alteration of SGECs in pSS participates in the establishment of a hyperosmolar microenvironment, which in turn promotes SGECs transcriptomic modifications. These modifications include extracellular matrix remodeling and promote SG lymphocytic infiltration.<\/jats:p>","DOI":"10.1093\/cei\/uxad020","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T04:51:19Z","timestamp":1676004679000},"page":"39-51","source":"Crossref","is-referenced-by-count":12,"title":["Hyperosmolar environment and salivary gland epithelial cells increase extra-cellular matrix remodeling and lymphocytic infiltration in Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1093","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-3081","authenticated-orcid":false,"given":"Elodie","family":"Rivi\u00e8re","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INSERM UMR 1184, Autoimmune disease laboratory, Center for immunology of viral infections and autoimmune diseases , Le Kremlin Bic\u00eatre , France"},{"name":"Rheumatology Department, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Bic\u00eatre , Le Kremlin Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Chivasso","sequence":"additional","affiliation":[{"name":"Laboratory of Pathophysiological and Nutritional Biochemistry, Faculty of Medicine, Universit\u00e9 Libre de Bruxelles , Brussels , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Pascaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INSERM UMR 1184, Autoimmune disease laboratory, Center for immunology of viral infections and autoimmune diseases , Le Kremlin Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Bechara","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INSERM UMR 1184, Autoimmune disease laboratory, Center for immunology of viral infections and autoimmune diseases , Le Kremlin Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bineta","family":"Ly","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INSERM UMR 1184, Autoimmune disease laboratory, Center for immunology of viral infections and autoimmune diseases , Le Kremlin Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Delporte","sequence":"additional","affiliation":[{"name":"Laboratory of Pathophysiological and Nutritional Biochemistry, Faculty of Medicine, Universit\u00e9 Libre de Bruxelles , Brussels , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Mariette","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, INSERM UMR 1184, Autoimmune disease laboratory, Center for immunology of viral infections and autoimmune diseases , Le Kremlin Bic\u00eatre , France"},{"name":"Rheumatology Department, Assistance Publique-H\u00f4pitaux de 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