{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:47:40Z","timestamp":1784299660144,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016290","name":"Cancer and Allergy Foundation","doi-asserted-by":"crossref","award":["2020-10154"],"award-info":[{"award-number":["2020-10154"]}],"id":[{"id":"10.13039\/100016290","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003849","name":"IngaBritt and Arne Lundberg Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003849","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["CAN 2018\/465"],"award-info":[{"award-number":["CAN 2018\/465"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Br\u00f6derna Eriksson Foundation"},{"DOI":"10.13039\/501100005760","name":"University of Gothenburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Eosinophilic esophagitis is a T-cell-driven allergic condition hallmarked by eosinophil infiltration of the esophagus. Eosinophils exposed to proliferating T cells release galectin-10 and have T-cell suppressive function in vitro. The aims of this study were to evaluate if eosinophils co-localize with T cells and release galectin-10 in the esophagus of patients with eosinophilic esophagitis. Esophageal biopsies from 20 patients with eosinophilic esophagitis were stained for major basic protein, galectin-10, CD4, CD8, CD16, and CD81 and analyzed by immunofluorescence confocal microscopy before and after topical corticosteroid treatment. CD4+ T-cell numbers decreased in the esophageal mucosa of responders to treatment but not in the non-responders. Suppressive (CD16+) eosinophils were present in the esophageal mucosa of patients with active disease and decreased after successful treatment. Unexpectedly, eosinophils and T cells were not in direct contact with each other. Instead, the esophageal eosinophils released large amounts of galectin-10-containing extracellular vesicles and featured cytoplasmic projections that contained galectin-10, both of which disappeared from the esophagus of the responders but remained in the non-responders. To conclude, the presence of CD16+ eosinophils together with the massive release of galectin-10-containing extracellular vesicles in the esophageal mucosa might indicate that eosinophils exert T-cell suppression in eosinophilic esophagitis.<\/jats:p>","DOI":"10.1093\/cei\/uxad026","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T19:43:37Z","timestamp":1676922217000},"page":"147-155","source":"Crossref","is-referenced-by-count":6,"title":["Extracellular distribution of galectin-10 in the esophageal mucosa of patients with eosinophilic esophagitis"],"prefix":"10.1093","volume":"212","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2038-4286","authenticated-orcid":false,"given":"Sofie","family":"Albinsson","sequence":"first","affiliation":[{"name":"Institute of Biomedicine, Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Lingblom","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden"},{"name":"Department of Clinical Microbiology, Sahlgrenska University Hospital , Region V\u00e4stra G\u00f6taland, Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of ENT, Head and Neck Surgery, Sk\u00f6vde County Hospital , Region V\u00e4stra G\u00f6taland, Sk\u00f6vde , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Larsson","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, Department of Otorhinolaryngology, Head and Neck Surgery, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, NU-Hospital Group , Region V\u00e4stra G\u00f6taland, Trollh\u00e4ttan , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Wenner\u00e5s","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden"},{"name":"Department of Clinical Microbiology, Sahlgrenska University Hospital , Region V\u00e4stra G\u00f6taland, Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"2023042515480026800_CIT0001","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1053\/j.gastro.2017.06.067","article-title":"Epidemiology and natural history of eosinophilic 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