{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T10:18:04Z","timestamp":1791627484542,"version":"4.3.4"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071625"],"award-info":[{"award-number":["82071625"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2017YCF1001200"],"award-info":[{"award-number":["2017YCF1001200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["SCU2019C4198"],"award-info":[{"award-number":["SCU2019C4198"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International Science and Technology Cooperation Project of Chengdu","award":["2017-GH02-000060-HZ"],"award-info":[{"award-number":["2017-GH02-000060-HZ"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endometriosis is a common inflammatory disorder in women of reproductive age due to an abnormal endometrial immune environment and is associated with infertility. This study aimed to systematically understand the endometrial leukocyte types, inflammatory environment, and impaired receptivity at single-cell resolution. We profiled single-cell RNA transcriptomes of 138 057 endometrial cells from endometriosis patients (n = 6) and control (n = 7), respectively, using 10x Genomics platform. We found that one cluster of epithelial cells that expressed PAEP and CXCL14 was mostly from the control during the window of implantation (WOI). This epithelial cell type is absent in the eutopic endometrium during the secretory phase. The proportion of endometrial immune cells decreased in the secretory phase in the control group, whereas the cycle variation of total immune cells, NK cells, and T cells was absent in endometriosis. Endometrial immune cells secreted more IL-10 in the secretory phase than in the proliferative phase in the control group; the opposite trend was observed in endometriosis. Proinflammatory cytokines levels in the endometrial immune cells were higher in endometriosis than in the control group. Trajectory analysis revealed that the secretory phase epithelial cells decreased in endometriosis. Ligand\u2013receptor analysis revealed that 11 ligand\u2013receptor pairs were upregulated between endometrial immune and epithelial cells during WOI. These results provide new insights into the endometrial immune microenvironment and impaired endometrial receptivity in infertile women with minimal\/mild endometriosis.<\/jats:p>","DOI":"10.1093\/cei\/uxad029","type":"journal-article","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T06:24:05Z","timestamp":1677911045000},"page":"285-295","source":"Crossref","is-referenced-by-count":65,"title":["Single-cell transcriptome analysis reveals endometrial immune microenvironment in minimal\/mild endometriosis"],"prefix":"10.1093","volume":"212","author":[{"given":"Xin","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Reproductive Medicine, West China Second University Hospital of Sichuan University , Chengdu, Sichuan , China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education , Chengdu, Sichuan , China"},{"name":"NHC Key Laboratory of Chronobiology (Sichuan University) , Chengdu, Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukanxuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine, West China Second University Hospital of Sichuan University , Chengdu, Sichuan , China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education , Chengdu, Sichuan , China"},{"name":"NHC Key Laboratory of Chronobiology (Sichuan University) , Chengdu, Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjiao","family":"Pei","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine, West China Second University Hospital of Sichuan University , Chengdu, Sichuan , China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education , Chengdu, Sichuan , China"},{"name":"NHC Key Laboratory of Chronobiology (Sichuan University) , Chengdu, Sichuan , 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of Sichuan University , Chengdu, Sichuan , China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education , Chengdu, Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xiao","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine, West China Second University Hospital of Sichuan University , Chengdu, Sichuan , China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education , Chengdu, Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine, West China Second University Hospital of Sichuan University , Chengdu, Sichuan , China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education , Chengdu, Sichuan , China"},{"name":"NHC Key Laboratory of Chronobiology (Sichuan University) , Chengdu, Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine, West China Second University Hospital of Sichuan University , Chengdu, Sichuan , China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education , Chengdu, Sichuan , China"},{"name":"NHC Key Laboratory of Chronobiology (Sichuan University) , Chengdu, Sichuan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunwei","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine, West China Second University Hospital of Sichuan University , Chengdu, Sichuan , China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education , Chengdu, Sichuan , 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