{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:36:16Z","timestamp":1790840176333,"version":"4.1.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","award":["PS 156104"],"award-info":[{"award-number":["PS 156104"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100019691","name":"Faculty of Medicine and Dentistry, University of Alberta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Li Ka Shing Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The immune system is composed of a variety of different T-cell lineages distributed through both secondary lymphoid tissue and non-lymphoid tissue. The intestinal epithelium is a critical barrier surface that contains numerous intraepithelial lymphocytes that aid in maintaining homeostasis at that barrier. This review focuses on T-cell receptor \u03b1\u03b2 (TCR\u03b1\u03b2) CD8\u03b1\u03b1 intraepithelial lymphocytes, and how recent advances in the field clarify how this unique T-cell subset is selected, matures, and functions in the intestines. We consider how the available evidence reveals a story of ontogeny starting from agonist selection of T cells in the thymus and finishing through the specific signaling environment of the intestinal epithelium. We conclude with how this story raises further key questions about the development of different ontogenic waves of TCR\u03b1\u03b2 CD8\u03b1\u03b1 IEL and their importance for intestinal epithelial homeostasis.<\/jats:p>","DOI":"10.1093\/cei\/uxad049","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:40:13Z","timestamp":1683160813000},"page":"67-75","source":"Crossref","is-referenced-by-count":10,"title":["Destined for the intestine: thymic selection of TCR<b>\u03b1\u03b2<\/b> CD8\u03b1\u03b1 intestinal intraepithelial lymphocytes"],"prefix":"10.1093","volume":"213","author":[{"given":"Kevin","family":"Joannou","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta , Edmonton, Alberta , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0122-3746","authenticated-orcid":false,"given":"Troy A","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta , Edmonton, Alberta , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"2023070613571525700_CIT0001","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.4049\/jimmunol.154.11.5611","article-title":"Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine","volume":"154","author":"Beagley","year":"1995","journal-title":"J Immunol"},{"key":"2023070613571525700_CIT0002","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/s41577-018-0013-7","article-title":"Diverse developmental pathways of intestinal intraepithelial lymphocytes","volume":"18","author":"McDonald","year":"2018","journal-title":"Nat Rev 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