{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:24:08Z","timestamp":1791437048289,"version":"4.3.3"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Angelo Donghia Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transplant-associated thrombotic microangiopathy (TA-TMA) is an endotheliopathy complicating up to 30% of allogeneic hematopoietic stem cell transplants (alloHSCT). Positive feedback loops among complement, pro-inflammatory, pro-apoptotic, and coagulation cascade likely assume dominant roles at different disease stages. We hypothesized that mannose-binding lectin-associated serine protease 2 (MASP2), principal activator of the lectin complement system, is involved in the microvascular endothelial cell (MVEC) injury characteristic of TA-TMA through pathways that are susceptible to suppression by anti-MASP2 monoclonal antibody narsoplimab. Pre-treatment plasmas from 8 of 9 TA-TMA patients achieving a complete TMA response in a narsoplimab clinical trial activated caspase 8, the initial step in apoptotic injury, in human MVEC. This was reduced to control levels following narsoplimab treatment in 7 of the 8 subjects. Plasmas from 8 individuals in an observational TA-TMA study, but not 8 alloHSCT subjects without TMA, similarly activated caspase 8, which was blocked in vitro by narsoplimab. mRNA sequencing of MVEC exposed to TA-TMA or control plasmas with and without narsoplimab suggested potential mechanisms of action. The top 40 narsoplimab-affected transcripts included upregulation of SerpinB2, which blocks apoptosis by inactivating procaspase 3; CHAC1, which inhibits apoptosis in association with mitigation of oxidative stress responses; and pro-angiogenesis proteins TM4SF18, ASPM, and ESM1. Narsoplimab also suppressed transcripts encoding pro-apoptotic and pro-inflammatory proteins ZNF521, IL1R1, Fibulin-5, aggrecan, SLC14A1, and LOX1, and TMEM204, which disrupts vascular integrity. Our data suggest benefits to narsoplimab use in high-risk TA-TMA and provide a potential mechanistic basis for the clinical efficacy of narsoplimab in this disorder.<\/jats:p>","DOI":"10.1093\/cei\/uxad055","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T14:21:48Z","timestamp":1684246908000},"page":"252-264","source":"Crossref","is-referenced-by-count":12,"title":["MASP2 inhibition by narsoplimab suppresses endotheliopathies characteristic of transplant-associated thrombotic microangiopathy:<i>in vitro<\/i>and<i>ex vivo<\/i>evidence"],"prefix":"10.1093","volume":"213","author":[{"given":"Sonia","family":"Elhadad","sequence":"first","affiliation":[{"name":"Department of Medicine , Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Redmond","sequence":"additional","affiliation":[{"name":"Division of Regenerative Medicine , Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Regenerative Medicine , Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Tan","sequence":"additional","affiliation":[{"name":"Genomics Resources Core Facility , Weill Cornell Medicine, New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8274-3144","authenticated-orcid":false,"given":"Jeffrey","family":"Laurence","sequence":"additional","affiliation":[{"name":"Department of Medicine , Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"2023072415483332000_CIT0001","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/bjh.16457","article-title":"Incidence, risk factors for outcomes of transplant-associated thrombotic microangiopathy","volume":"189","author":"Epperla","year":"2020","journal-title":"Br J Haematol"},{"key":"2023072415483332000_CIT0002","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jtct.2022.11.015","article-title":"Harmonizing definitions for diagnostic criteria and prognostic assessment of transplantation-associated thrombotic microangiopathy: a report on behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research","volume":"29","author":"Schoettler","year":"2023","journal-title":"Transplant Cellular Ther"},{"key":"2023072415483332000_CIT0003","first-page":"565","article-title":"Hematopoietic transplant-associated thrombotic microangiopathy: case report and review of diagnosis and treatments","volume":"12","author":"Chapin","year":"2014","journal-title":"Clin Adv Hematol Oncol"},{"key":"2023072415483332000_CIT0004","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1182\/bloodadvances.2020001515","article-title":"Interferon-complement loop in transplant-associated thrombotic microangiopathy","volume":"4","author":"Jodele","year":"2020","journal-title":"Blood Adv"},{"key":"2023072415483332000_CIT0005","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.bbmt.2018.01.009","article-title":"Early increase in complement terminal pathway activation marker sC5b-9 is predictive for the development of thrombotic microangiopathy after stem cell transplantation","volume":"24","author":"Horvath","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"2023072415483332000_CIT0006","first-page":"1","article-title":"Atypical hemolytic uremic syndrome (aHUS): essential aspects of an accurate diagnosis","volume":"14","author":"Laurence","year":"2016","journal-title":"Clin Adv Hematol Oncol"},{"key":"2023072415483332000_CIT0007","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1182\/blood-2015-08-663435","article-title":"The genetic fingerprint of susceptibility for transplant-associated thrombotic microangiopathy","volume":"127","author":"Jodele","year":"2016","journal-title":"Blood"},{"key":"2023072415483332000_CIT0008","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/cei.13497","article-title":"MASP2 levels are elevated in thrombotic microangiopathies: association with microvascular endothelial cell injury and suppression by anti-MASP2 antibody narsoplimab","volume":"203","author":"Elhadad","year":"2021","journal-title":"Clin Exp Immunol"},{"key":"2023072415483332000_CIT0009","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1055\/s-0039-1692721","article-title":"Linking complement activation, coagulation, and neutrophils in transplant-associated thrombotic microangiopathy","volume":"119","author":"Gavriilak","year":"2019","journal-title":"Thromb Haemost"},{"key":"2023072415483332000_CIT0010","first-page":"e1","article-title":"Prognostic biomarkers for thrombotic microangiopathy after acute graft-versus-host disease: a nested case-control study","volume":"308","author":"Li","year":"2021","journal-title":"Transplant Cell Ther"},{"key":"2023072415483332000_CIT0011","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s00277-017-3092-9","article-title":"Plasma levels of complement activation fragments C3b and sC5b-9 significantly increased in patients with thrombotic microangiopathy after allogeneic stem cell transplantation","volume":"96","author":"Qi","year":"2017","journal-title":"Ann Hematol"},{"key":"2023072415483332000_CIT0012","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/s41409-022-01723-5","article-title":"Complement C5b-9 and MASP2 deposition in cutaneous and bone marrow microvasculature of patients with allogeneic hematopoietic stem cell transplant-associated thrombotic microangiopathy","volume":"57","author":"Elhadad","year":"2022","journal-title":"Bone Marrow Transplant"},{"key":"2023072415483332000_CIT0013","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s40164-021-00249-8","article-title":"Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy","volume":"10","author":"Gavriilaki","year":"2021","journal-title":"Exper Hematol Oncol"},{"key":"2023072415483332000_CIT0014","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.bbmt.2013.12.565","article-title":"Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy","volume":"20","author":"Jodele","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"2023072415483332000_CIT0015","first-page":"1049","article-title":"Complement blockade for TA-TMA: lessons learned from a large pediatric cohort treated with eculizumab","volume":"135","author":"Jodele","year":"2020","journal-title":"Blood"},{"key":"2023072415483332000_CIT0016","doi-asserted-by":"crossref","first-page":"564647","DOI":"10.3389\/fimmu.2020.564647","article-title":"Efficacy and safety of eculizumab in the treatment of transplant-associated thrombotic microangiopathy: a systematic review and meta-analysis","volume":"11","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"2023072415483332000_CIT0017","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1200\/JCO.21.02389","article-title":"Narsoplimab, a mannan-binding lectin-associated serine protease-2 inhibitor, for the treatment of adult hematopoietic stem-cell transplantation-associated thrombotic microangiopathy","volume":"40","author":"Khaled","year":"2022","journal-title":"J Clin Oncol"},{"key":"2023072415483332000_CIT0018","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1182\/bloodadvances.2020002007","article-title":"Risk factors and appropriate therapeutic strategies for thrombotic microangiopathy after allogeneic HSCT","volume":"4","author":"Matsui","year":"2020","journal-title":"Blood Adv"},{"key":"2023072415483332000_CIT0019","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1182\/blood-2007-10-119552","article-title":"Synergistic interactions between interferon-\u03b3 and TRAIL modulate c-FLIP in endothelial cells, mediating their lineage-specific sensitivity to thrombotic thrombocytopenic purpura plasma-associated apoptosis","volume":"112","author":"Stefanescu","year":"2008","journal-title":"Blood"},{"key":"2023072415483332000_CIT0020","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41409-018-0293-3","article-title":"High mortality in hematopoietic stem cell transplant-associated thrombotic microangiopathy with and without concomitant graft-versus-host disease","volume":"54","author":"Kraft","year":"2019","journal-title":"Bone Marrow Transplant"},{"key":"2023072415483332000_CIT0021","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"2023072415483332000_CIT0022","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1186\/s12859-019-3234-2","article-title":"deltaRpkm: an R package for a rapid detection of differential gene presence between related bacterial genomes","volume":"20","author":"Akarsu","year":"2019","journal-title":"BMC Bioinf"},{"key":"2023072415483332000_CIT0023","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat Biotech"},{"key":"2023072415483332000_CIT0024","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"40","author":"Luiao","year":"2014","journal-title":"Bioinformatics"},{"key":"2023072415483332000_CIT0025","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR; a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2023072415483332000_CIT0026","doi-asserted-by":"crossref","first-page":"W199","DOI":"10.1093\/nar\/gkz401","article-title":"WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2023072415483332000_CIT0027","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0046-8177(89)90210-4","article-title":"Novel histopathologic findings in a surviving case of hemolytic uremic syndrome after bone marrow transplantation","volume":"20","author":"Arends","year":"1989","journal-title":"Hum Pathol"},{"key":"2023072415483332000_CIT0028","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1600-0609.1989.tb00284.x","article-title":"Vascular endothelial cell function and ultrastructure in thrombotic microangiopathy following allogeneic bone marrow transplant-associated thrombotic microangiopathy","volume":"43","author":"Cohen","year":"1989","journal-title":"Eur J Hematol"},{"key":"2023072415483332000_CIT0029","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1038\/s41409-021-01283-0","article-title":"Transplant-associated thrombotic microangiopathy: theoretical considerations and a practical approach to an unrefined diagnosis","volume":"56","author":"Young","year":"2021","journal-title":"Bone Marrow Transplant"},{"key":"2023072415483332000_CIT0030","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1182\/blood-2011-02-321315","article-title":"Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation-associated thrombotic microangiopathy","volume":"118","author":"Laskin","year":"2011","journal-title":"Blood"},{"key":"2023072415483332000_CIT0031","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1182\/blood.V93.4.1264","article-title":"Enhanced endothelial cell apoptosis in splenic tissues of patients with idiopathic thrombotic thrombocytopenic purpura","volume":"93","author":"Dang","year":"1999","journal-title":"Blood"},{"key":"2023072415483332000_CIT0032","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.4049\/jimmunol.171.3.1526","article-title":"TRAIL induces apoptosis and inflammatory gene expression in human endothelial cells","volume":"171","author":"Li","year":"2003","journal-title":"J Immunol"},{"key":"2023072415483332000_CIT0033","doi-asserted-by":"crossref","article-title":"Development of pharmacodynamic assays to assess ex vivo Masp-2 inhibition and their use to characterize the pharmacodynamics of narsoplimab (OMS721) in humans and monkeys","author":"Freeman","DOI":"10.1182\/blood-2020-142208"},{"key":"2023072415483332000_CIT0034","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1182\/bloodadvances.2019000143","article-title":"Allogeneic reactivity-mediated endothelial cell complications after HSCT: a plea for consensual definitions","volume":"3","author":"Pagliuca","year":"2019","journal-title":"Blood Adv"},{"key":"2023072415483332000_CIT0035","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3390\/molecules26051277","article-title":"Induction of apoptosis and regulation of microRNA expression by (2E,6E)-2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) treatment on MCF-7 breast cancer cells","volume":"26","author":"Yeap","year":"2021","journal-title":"Molecules"},{"key":"2023072415483332000_CIT0036","doi-asserted-by":"crossref","first-page":"113237","DOI":"10.1016\/j.biopha.2022.113237","article-title":"Interplays between non-coding RNAs and chemokines in digestive system cancers","volume":"152","author":"Jafarzadeh","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"2023072415483332000_CIT0037","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.immuni.2010.07.012","article-title":"The mysterious ways of the chemokine CXCL5","volume":"33","author":"Koltsova","year":"2010","journal-title":"Immunity"},{"key":"2023072415483332000_CIT0038","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1165\/rcmb.2005-0063OC","article-title":"Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium","volume":"32","author":"Jeyaseelan","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2023072415483332000_CIT0039","doi-asserted-by":"crossref","first-page":"7508","DOI":"10.1080\/21655979.2021.1979440","article-title":"Down regulation of circ-UBAP2 ameliorates oxidative stress and dysfunctions of human retinal microvascular endothelial cells (hRMECs) via miR-589-5p\/EGR1 axis","volume":"12","author":"Jiewel","year":"2021","journal-title":"Bioengineered"},{"key":"2023072415483332000_CIT0040","doi-asserted-by":"crossref","first-page":"e023539","DOI":"10.1161\/JAHA.121.023539","article-title":"Early growth response-1, an integrative sensor in cardiovascular and inflammatory disease","volume":"10","author":"Khachigian","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2023072415483332000_CIT0041","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/j.bbadis.2016.07.017","article-title":"Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2","volume":"1862","author":"An","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"2023072415483332000_CIT0042","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/s41419-019-1734-7","article-title":"Mitochondrial miR-762 regulates apoptosis and myocardial infarction by impairing ND2","volume":"10","author":"Yan","year":"2019","journal-title":"Cell Death Dis"},{"key":"2023072415483332000_CIT0043","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1242\/jcs.204974","article-title":"The serine protease inhibitor serpinB2 binds and stabilizes p21 in senescent cells","volume":"130","author":"Hsieh","year":"2017","journal-title":"J Cell Sci"},{"key":"2023072415483332000_CIT0044","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1681\/ASN.2019101085","article-title":"SerpinB2 regulates immune response in kidney injury and aging","volume":"31","author":"Sen","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"2023072415483332000_CIT0045","doi-asserted-by":"crossref","first-page":"E177","DOI":"10.1073\/pnas.1119296109","article-title":"TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2\/serpinB2 and transglutaminase 2","volume":"109","author":"Delhase","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072415483332000_CIT0046","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.1038\/onc.2008.334","article-title":"TTK\/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress","volume":"27","author":"Nihira","year":"2008","journal-title":"Oncogene"},{"key":"2023072415483332000_CIT0047","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1038\/bjc.2014.460","article-title":"Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells","volume":"111","author":"Kaistha","year":"2014","journal-title":"Br J Cancer"},{"key":"2023072415483332000_CIT0048","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.3389\/fimmu.2018.02823","article-title":"CHAC1 is differentially expressed in normal and cystic fibrosis bronchial epithelial cells and regulates the inflammatory response induced by Pseudomonas aeruginosa","volume":"9","author":"Perra","year":"2018","journal-title":"Front Immunol"},{"key":"2023072415483332000_CIT0049","doi-asserted-by":"crossref","first-page":"e1382","DOI":"10.1002\/wsbm.1382","article-title":"Systems biology of oxygen homeostasis","volume":"9","author":"Samanta","year":"2017","journal-title":"IWIREs Syst Biol Med"},{"key":"2023072415483332000_CIT0050","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1016\/j.celrep.2019.05.052","article-title":"Positive feedback defines the timing, magnitude, and robustness of angiogenesis","volume":"27","author":"Page","year":"2019","journal-title":"Cell Rep"},{"key":"2023072415483332000_CIT0051","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.1038\/s41598-018-23653-3","article-title":"A multi-step transcriptional cascade underlies vascular regeneration in vivo","volume":"8","author":"Shirali","year":"2018","journal-title":"Sci Rep"},{"key":"2023072415483332000_CIT0052","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1161\/CIRCRESAHA.115.304718","article-title":"Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability","volume":"115","author":"Rocha","year":"2014","journal-title":"Circ Res"},{"key":"2023072415483332000_CIT0053","doi-asserted-by":"crossref","first-page":"69436","DOI":"10.18632\/oncotarget.11683","article-title":"TNSF15 suppresses VEGF production in endothelial cells by stimulating mir-29b expression via activation of JNK-GATA3 signals","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"2023072415483332000_CIT0054","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.7150\/jca.45190","article-title":"ZNF521 which is downregulated by miR-802 suppresses malignant progression of hepatocellular carcinoma through regulating Runx2 expression","volume":"11","author":"Yang","year":"2020","journal-title":"J Cancer"},{"key":"2023072415483332000_CIT0055","doi-asserted-by":"crossref","first-page":"R96","DOI":"10.1530\/VB-21-0010","article-title":"Interleukin role in the regulation of endothelial cell pathological activation","volume":"3","author":"Carbone","year":"2021","journal-title":"Vascular Biol"},{"key":"2023072415483332000_CIT0056","doi-asserted-by":"crossref","first-page":"e0156994","DOI":"10.1371\/journal.pone.0156994","article-title":"Fibulib-5 regulates angiopoietin-1\/Tie-2 receptor signaling in endothelial cells","volume":"11","author":"Chan","year":"2016","journal-title":"PLoS One"},{"key":"2023072415483332000_CIT0057","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/104454904323145254","article-title":"Fibulin-5 antagonizes vascular endothelial growth factor (VEGF) signaling and angiogenic sprouting by endothelial cells","volume":"23","author":"Albig","year":"2004","journal-title":"DNA Cell Biol"},{"key":"2023072415483332000_CIT0058","doi-asserted-by":"crossref","first-page":"e29641","DOI":"10.1002\/pbc.29641","article-title":"A pilot trial of prophylactic defibrotide to prevent serious thrombotic microangiopathy in high-risk pediatric patients","volume":"69","author":"Higham","year":"2022","journal-title":"Pediatr Blood Cancer"},{"key":"2023072415483332000_CIT0059","doi-asserted-by":"crossref","first-page":"145","DOI":"10.5483\/BMBRep.2019.52.2.282","article-title":"Endothelial dysfunction induces atherosclerosis: increased aggrecan expression promotes apoptosis in vascular smooth muscle cells","volume":"52","author":"Kim","year":"2019","journal-title":"BMB Rep"},{"key":"2023072415483332000_CIT0060","doi-asserted-by":"crossref","first-page":"A13295","DOI":"10.1161\/circ.142.suppl_3.13295","article-title":"Novel experimental therapeutics for COVID-19 derived from a nitric oxide donor","volume":"142","author":"Schmedtje","year":"2020","journal-title":"Circulation"},{"key":"2023072415483332000_CIT0061","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.atherosclerosis.2014.04.028","article-title":"Ox-LDL induces endothelial cell apoptosis via the LOX-1-dependent endoplasmic reticulum stress pathway","volume":"235","author":"Hong","year":"2014","journal-title":"Atherosclerosis"},{"key":"2023072415483332000_CIT0062","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1111\/j.1432-1033.2004.04186.x","article-title":"A novel four transmembrane spanning protein, CLP24 a hypoxically regulated cell junction protein","volume":"271","author":"Kearsey","year":"2004","journal-title":"Eur J Biochem"},{"key":"2023072415483332000_CIT0063","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.thromres.2010.11.024","article-title":"Gene expression analysis of HUVEC in response to TF-binding","volume":"127","author":"Grosser","year":"2011","journal-title":"Thromb Res"},{"key":"2023072415483332000_CIT0064","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.3892\/mmr.2015.3861","article-title":"Identification of proteins interacting with protein kinase C-\u03b4 in hyperthermia-induced apoptosis and thermotolerance of Tca8113 cells","volume":"12","author":"Liu","year":"2015","journal-title":"Mol Med Rep"},{"key":"2023072415483332000_CIT0065","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1091\/mbc.9.6.1589","article-title":"Cleavage of \u03b2-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases","volume":"9","author":"Herren","year":"1998","journal-title":"Mol Biol Cell"},{"key":"2023072415483332000_CIT0066","first-page":"440","article-title":"Exosomal miR-142-3p is increased during cardiac allograft rejection and augments vascular permeability through down-regulation of endothelial RAB11FIP2 expression","volume":"113","author":"Dewi","year":"2017","journal-title":"Cardiovasc Res"},{"key":"2023072415483332000_CIT0067","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3390\/jcm11030623","article-title":"Endothelial dysfunction after hematopoietic stem cell transplantation: a review based on physiopathology","volume":"11","author":"Milone","year":"2022","journal-title":"J Clin Med"},{"key":"2023072415483332000_CIT0068","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/bmt.2017.207","article-title":"Hematopoietic stem cell transplant-associated thrombotic microangiopathy: current paradigm and novel therapies","volume":"53","author":"Khosla","year":"2018","journal-title":"Bone Marrow Transplant"},{"key":"2023072415483332000_CIT0069","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1055\/s-0038-1654714","article-title":"The lectin pathway in thrombotic conditions\u2014a systematic review","volume":"118","author":"Larsen","year":"2018","journal-title":"Thromb Haemost"},{"key":"2023072415483332000_CIT0070","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1038\/s41598-020-60158-4","article-title":"Human primary endothelial label-free biochip assay reveals unpredicted functions of plasma serine proteases","volume":"10","author":"Debreczeni","year":"2020","journal-title":"Sci Rep"},{"key":"2023072415483332000_CIT0071","doi-asserted-by":"crossref","first-page":"e59372","DOI":"10.1371\/journal.pone.0059372","article-title":"Assembly and activation of alternative complement components on endothelial cell-anchored ultra-large von Willebrand factor links complement and hemostasis-thrombosis","volume":"8","author":"Turner","year":"2013","journal-title":"PLoS One"},{"key":"2023072415483332000_CIT0072","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.1074\/jbc.RA118.002639","article-title":"Brain microvascular endothelial cells exhibit lower activation of the alternative complement pathway than glomerular microvascular endothelial cells","volume":"293","author":"Sartain","year":"2018","journal-title":"J Biol Chem"},{"key":"2023072415483332000_CIT0073","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3389\/fimmu.2017.01115","article-title":"Factor XII-driven inflammatory reactions with implications for anaphylaxis","volume":"8","author":"Bender","year":"2017","journal-title":"Front Immunol"},{"key":"2023072415483332000_CIT0074","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.transproceed.2012.01.089","article-title":"Apoptosis in endothelial cells by cyclosporine","volume":"44","author":"Hwang","year":"2012","journal-title":"Transplant Proc"},{"key":"2023072415483332000_CIT0075","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tiv.2018.07.017","article-title":"Tacrolimus inhibits angiogenesis and induces disaggregation of endothelial cells in spheroids\u2014toxicity testing in a 3D cell culture approach","volume":"53","author":"Thoms","year":"2018","journal-title":"Toxicol In Vitro"},{"key":"2023072415483332000_CIT0076","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3892\/mmr.2021.11994","article-title":"The effect of anti-HLA class I antibodies on the immunological properties of human glomerular endothelial cells and their modification by mTOR inhibition or GCN2 kinase activation","volume":"23","author":"Eleftheriadis","year":"2021","journal-title":"Mol Med Rep"},{"key":"2023072415483332000_CIT0077","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/cam4.185","article-title":"Targeting of tumor endothelial cells combining 2 Gy\/day of X-ray with Everolimus is the effective modality for overcoming clinically relevant radioresistant tumors","volume":"3","author":"Kuwahara","year":"2013","journal-title":"Cancer Med"},{"key":"2023072415483332000_CIT0078","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.2353\/ajpath.2009.090152","article-title":"The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy","volume":"175","author":"Hayashi","year":"2009","journal-title":"Am J Pathol"},{"key":"2023072415483332000_CIT0079","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2020.04.007","article-title":"Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases","volume":"220","author":"Magro","year":"2020","journal-title":"Transl Res"},{"key":"2023072415483332000_CIT0080","doi-asserted-by":"crossref","first-page":"e161167","DOI":"10.1172\/JCI161167","article-title":"Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches","volume":"132","author":"Ahamed","year":"2022","journal-title":"J Clin Invest"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cei\/advance-article-pdf\/doi\/10.1093\/cei\/uxad055\/50660886\/uxad055.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/213\/2\/252\/50947700\/uxad055.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/213\/2\/252\/50947700\/uxad055.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T13:36:50Z","timestamp":1729431410000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/213\/2\/252\/7165119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":80,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,5,16]]},"published-print":{"date-parts":[[2023,7,21]]}},"URL":"https:\/\/doi.org\/10.1093\/cei\/uxad055","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,8,1]]},"published":{"date-parts":[[2023,5,16]]}}}