{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:42:32Z","timestamp":1790390552578,"version":"4.1.0"},"reference-count":99,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060302"],"award-info":[{"award-number":["82060302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260325"],"award-info":[{"award-number":["82260325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Education Science and Technology Innovation Project of Gansu Province"},{"name":"Higher Education Innovation Fund of Gansu Province","award":["2022B-051"],"award-info":[{"award-number":["2022B-051"]}]},{"name":"Medical Innovation and Development Project of Lanzhou University","award":["lzuyxcx-2022-168"],"award-info":[{"award-number":["lzuyxcx-2022-168"]}]},{"name":"Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital","award":["CY2021-MS-A04"],"award-info":[{"award-number":["CY2021-MS-A04"]}]},{"name":"Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital","award":["CY2021-QN-B02"],"award-info":[{"award-number":["CY2021-QN-B02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,21]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Idiopathic inflammatory myopathies (IIMs) are a group of systemic autoimmune diseases characterized by immune-mediated muscle injury. Abnormal neutrophil extracellular traps (NETs) can be used as a biomarker of IIM disease activity, but the mechanism of NET involvement in IIMs needs to be elucidated. Important components of NETs, including high-mobility group box 1, DNA, histones, extracellular matrix, serum amyloid A, and S100A8\/A9, act as damage-associated molecular patterns (DAMPs) to promote inflammation in IIMs. NETs can act on different cells to release large amounts of cytokines and activate the inflammasome, which can subsequently aggravate the inflammatory response. Based on the idea that NETs may be proinflammatory DAMPs of IIMs, we describe the role of NETs, DAMPs, and their interaction in the pathogenesis of IIMs and discuss the possible targeted treatment strategies in IIMs.<\/jats:p>","DOI":"10.1093\/cei\/uxad059","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T19:05:55Z","timestamp":1686251155000},"page":"202-208","source":"Crossref","is-referenced-by-count":23,"title":["The role of neutrophil extracellular traps and proinflammatory damage-associated molecular patterns in idiopathic inflammatory myopathies"],"prefix":"10.1093","volume":"213","author":[{"given":"Wenlan","family":"Ma","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College, Lanzhou University , Lanzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cuiying Biomedical Research Center, Lanzhou University Second Hospital , Lanzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Bai","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Lanzhou University , Lanzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Lanzhou University , Lanzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Lanzhou University , Lanzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1565-1431","authenticated-orcid":false,"given":"Sigong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Lanzhou University Second Hospital , Lanzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"2023072415490293200_CIT0001","doi-asserted-by":"crossref","first-page":"199","DOI":"10.55563\/clinexprheumatol\/vskjxi","article-title":"Idiopathic inflammatory myopathies: one year in review 2021","volume":"40","author":"Cardelli","year":"2022","journal-title":"Clin Exp Rheumatol"},{"key":"2023072415490293200_CIT0002","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrrheum.2018.48","article-title":"Risk factors and disease mechanisms in myositis","volume":"14","author":"Miller","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"2023072415490293200_CIT0003","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nrrheum.2018.42","article-title":"Treatment in myositis","volume":"14","author":"Oddis","year":"2018","journal-title":"Nat Rev 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