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Two treatment schedules were used: an experimental regime (ER) and a conventional treatment (CT). Mononuclear cells from patients with DKS\/HIV were obtained at baseline (W0), 4 (W4), and 12 weeks (W12). Ten DKS\/HIV patients received CT (antiretroviral therapy [cART]) and 10 ER (valganciclovir [VGC] initially, plus cART at the fourth week). HIV+ without KS and HIV\u2212 patient groups were included as controls. Correlation between T-cell subsets and HHV-8 viral load (VL) and a multivariate linear regression was performed. Data showed that DKS\/HIV patients have an increased frequency of CD8+ T cells, which display a high density of CD8 expression. The ER scheme increases na\u00efve and central memory CD4+ T cells at W4 and W12 of follow-up and induces a balanced distribution of activated CD4+ T-cell subsets. Moreover, ER decreases solTNFR2 since W4 and CT decreased the transmembrane forms of TNF axis molecules. Although CT induces a positive correlation between HHV-8 VL and TNFRs, the use of ER positively correlates with TNF and TNFRs levels through follow-up and a moderate correlation with HHV-8 VL and TNF soluble levels. In conclusion, VGC, as an add-on therapy in DKS\/HIV patients, gradually modulates the activation of CD4+ T-cell subsets and the TNF\/TNFRs axis, suggesting a better regulation of the inflammatory status.<\/jats:p>","DOI":"10.1093\/cei\/uxad115","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T08:06:55Z","timestamp":1698739615000},"page":"190-201","source":"Crossref","is-referenced-by-count":3,"title":["Valganciclovir modulates the tumor necrosis factor axis molecules expression and CD4+ T-cell subsets in disseminated Kaposi Sarcoma patients"],"prefix":"10.1093","volume":"215","author":[{"given":"Lucero A","family":"Ramon-Luing","sequence":"first","affiliation":[{"name":"Laboratory of Integrative Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas , Mexico City , 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