{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:36:24Z","timestamp":1785148584032,"version":"3.55.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Academy for Healthcare, Region J\u00f6nk\u00f6ping County","award":["FUTURUM-936119"],"award-info":[{"award-number":["FUTURUM-936119"]}]},{"name":"Academy for Healthcare, Region J\u00f6nk\u00f6ping County","award":["962245"],"award-info":[{"award-number":["962245"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Type 1 diabetes (T1D) and celiac disease (CeD) are common autoimmune diseases in children where the pathophysiology is not fully characterized. The autoimmune process involves a complex scenario of both inflammatory and regulatory features. Galectin-1 (GAL-1) has a wide range of biological activities e.g. interaction with immune cells. We examined the relationship between GAL-1 and soluble immune markers and T-cell subsets in a cohort of children with T1D and\/or CeD relative to healthy children. GAL-1, together with several soluble immune markers [e.g. interleukins (IL)], tumor necrosis factor (TNF), acute phase proteins, and matrix metalloproteinases (MMP) were measured in sera from children with T1D and\/or CeD by fluorochrome (Luminex) technique using children without these diseases as a reference. Subgroups of T cells, including T-regulatory (Treg) cells, were analysed by flow cytometry. Association between GAL-1, pro-inflammatory markers, and Treg cells differed depending on which illness combination was present. In children with both T1D and CeD, GAL-1 correlated positively with pro-inflammatory markers (IL-1\u03b2, IL-6, and TNF-\u03b1). Composite scores increased the strength of correlation between GAL-1 and pro-inflammatory markers, Th1-associated interferon (IFN)-\u03b3, and T1D-associated visfatin. Contrary, in children diagnosed with exclusively T1D, GAL-1 was positively correlated to CD25hi and CD25hiCD101+ Treg cells. For children with only CeD, no association between GAL-1 and other immune markers was observed. In conclusion, the association observed between GAL-1, soluble immune markers, and Treg cells may indicate a role for GAL-1 in the pathophysiology of T1D and, to some extent, also in CeD.<\/jats:p>","DOI":"10.1093\/cei\/uxad131","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T15:07:45Z","timestamp":1702480065000},"page":"240-250","source":"Crossref","is-referenced-by-count":6,"title":["Galectin-1 correlates with inflammatory markers and T regulatory cells in children with type 1 diabetes and\/or celiac disease"],"prefix":"10.1093","volume":"215","author":[{"given":"Emanuel","family":"Fryk","sequence":"first","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Wilsson","sequence":"additional","affiliation":[{"name":"Department of Natural Science and Biomedicine, School of Health and Welfare, J\u00f6nk\u00f6ping University , J\u00f6nk\u00f6ping , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tompa","sequence":"additional","affiliation":[{"name":"Department of Natural Science and Biomedicine, School of Health and Welfare, J\u00f6nk\u00f6ping University , J\u00f6nk\u00f6ping , Sweden"},{"name":"Division of Medical Diagnostics, Department of Laboratory Medicine , Region J\u00f6nk\u00f6ping County , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per-Anders","family":"Jansson","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg , Gothenburg , 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