{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:21:02Z","timestamp":1785111662678,"version":"3.55.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009752","name":"FUTURUM","doi-asserted-by":"crossref","award":["941901, FUTURUM-962245"],"award-info":[{"award-number":["941901, FUTURUM-962245"]}],"id":[{"id":"10.13039\/501100009752","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Region J\u00f6nk\u00f6ping County, J\u00f6nk\u00f6ping, Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Our purpose was to characterize the pattern of B cell subsets in children with a combined diagnosis of type 1 diabetes (T1D) and celiac disease (C) since children with single or double diagnosis of these autoimmune diseases may differ in peripheral B cell subset phenotype patterns. B cells were analyzed with flow cytometry for the expression of differentiation\/maturation markers to identify transitional, naive, and memory B cells. Transitional (CD24hiCD38hiCD19+) and memory Bregs (mBregs; CD24hiCD27+CD19+, CD1d+CD27+CD19+, and CD5+CD1d+CD19+) were classified as B cells with regulatory capacity. Children with a combined diagnosis of T1D and C showed a pattern of diminished peripheral B cell subsets. The B cells compartment in children with combined diagnosis had higher percentages of memory B subsets and Bregs, including activated subsets, compared to children with either T1D or C. Children with combined diagnosis had a lower percentage of naive B cells (CD27\u2212CD19+; IgD+CD19+) and an increased percentage of memory B cells (CD27+CD19+; IgD\u2212CD19+). A similar alteration was seen among the CD39+ expressing naive and memory B cells. Memory Bregs (CD1d+CD27+CD19+) were more frequent, contrary to the lower percentage of CD5+ transitional Bregs in children with a combined diagnosis. In children with either T1D or C, the peripheral B cell compartment was dominated by naive cells. Differences in the pattern of heterogeneous peripheral B cell repertoire subsets reflect a shifting in the B cell compartment between children with T1D and\/or C. This is an immunological challenge of impact on the pathophysiology of these autoimmune diseases.<\/jats:p>","DOI":"10.1093\/cei\/uxad136","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T18:56:39Z","timestamp":1703271399000},"page":"36-44","source":"Crossref","is-referenced-by-count":11,"title":["Shift in the B cell subsets between children with type 1 diabetes and\/or celiac disease"],"prefix":"10.1093","volume":"216","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7995-3546","authenticated-orcid":false,"given":"Andrea","family":"Tompa","sequence":"first","affiliation":[{"name":"Department of Natural Science and Biomedicine, School of Health and Welfare, J\u00f6nk\u00f6ping University , J\u00f6nk\u00f6ping , Sweden"},{"name":"Division of Diagnostics , Region J\u00f6nk\u00f6ping County, J\u00f6nk\u00f6ping , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9385-6825","authenticated-orcid":false,"given":"Maria","family":"Faresj\u00f6","sequence":"additional","affiliation":[{"name":"Department of Natural Science and Biomedicine, School of Health and Welfare, J\u00f6nk\u00f6ping University , J\u00f6nk\u00f6ping , Sweden"},{"name":"Department of Life Sciences, Division of Systems and Synthetic Biology, Chalmers University of Technology , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"2024031215033736700_CIT0001","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1172\/JCI85113","article-title":"Human regulatory B cells in health and disease: therapeutic potential","volume":"127","author":"Mauri","year":"2017","journal-title":"J Clin 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