{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:27:17Z","timestamp":1788463637195,"version":"build-2803163510"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Key Research and Development and Promotion Special Foundation of Henan Province","award":["232102311022"],"award-info":[{"award-number":["232102311022"]}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["202300410458"],"award-info":[{"award-number":["202300410458"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2019-ZD-0801 and LJKZ0796"],"award-info":[{"award-number":["2019-ZD-0801 and LJKZ0796"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Allergic asthma (AA) is closely associated with the polarization of T helper (Th)2 and Th17 cells. Interleukin (IL)-18 acts as an inducer of Th2 and Th17 cell responses. However, expressions of IL-18 and IL-18 receptor alpha (IL-18R\u03b1) in blood Th2 and Th17 cells of patients with AA remain unclear. We therefore investigated their expressions in Th2 and Th17 cells using flow cytometric analysis, quantitative real-time PCR (qPCR), and murine AA model. We observed increased proportions of Th2, Th17, IL-18+, IL-18+ Th2, and IL-18+ Th17 cells in blood CD4+ T cells of patients with AA. Additionally, house dust mite seemed to upregulate further IL-18 expression in Th2 and Th17, and upregulate IL-18R\u03b1 expression in CD4+ T, Th2, and Th17 cells of AA patients. It was also found that the plasma levels of IL-4, IL-17A, and IL-18 in AA patients were elevated, and they were correlated between each other. In ovalbumin (OVA)-induced asthma mouse (AM), we observed that the percentages of blood CD4+ T, Th2, and Th17 cells were increased. Moreover, OVA-induced AM expressed higher level of IL-18R\u03b1 in blood Th2 cells, which was downregulated by IL-18. Increased IL-18R\u03b1 expression was also observed in blood Th2 cells of OVA-induced Fc\u03b5RI\u03b1\u2212\/\u2212 mice. Collectively, our findings suggest the involvement of Th2 cells in AA by expressing excessive IL-18 and IL-18R\u03b1 in response to allergen, and that IL-18 and IL-18R\u03b1 expressing Th2 cells are likely to be the potential targets for AA therapy.<\/jats:p>","DOI":"10.1093\/cei\/uxae022","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T04:54:38Z","timestamp":1712292878000},"page":"31-44","source":"Crossref","is-referenced-by-count":11,"title":["Allergens induce upregulated IL-18 and IL-18R\u03b1 expression in blood Th2 and Th17 cells of patients with allergic asthma"],"prefix":"10.1093","volume":"217","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0282-8278","authenticated-orcid":false,"given":"Junling","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Henan Provincial People\u2019s Hospital, Zhengzhou University People\u2019s Hospital , Zhengzhou, Henan , China"},{"name":"Department of Respiration, Huaihe Hospital of Henan University , Kaifeng, Henan , China"},{"name":"Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Jinzhou Medical University , Jinzhou, Liaoning , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Henan Provincial People\u2019s Hospital, Zhengzhou University People\u2019s Hospital , Zhengzhou, Henan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Henan Provincial People\u2019s Hospital, Zhengzhou University People\u2019s Hospital , Zhengzhou, Henan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Henan Provincial People\u2019s Hospital, Zhengzhou University People\u2019s Hospital , Zhengzhou, Henan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangqiu","family":"Gu","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Jinzhou Medical University , Jinzhou, Liaoning , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Jinzhou Medical University , Jinzhou, Liaoning , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaolong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Henan Provincial People\u2019s Hospital, Zhengzhou University People\u2019s Hospital , Zhengzhou, Henan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Henan Provincial People\u2019s Hospital, Zhengzhou University People\u2019s Hospital , Zhengzhou, Henan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Henan Provincial People\u2019s Hospital, Zhengzhou University People\u2019s Hospital , Zhengzhou, Henan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiration, Huaihe Hospital of Henan University , Kaifeng, Henan , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Henan Provincial 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