{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:51:48Z","timestamp":1785369108865,"version":"3.55.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Second European and Developing Countries Clinical Trials Partnership"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["TMA2016SF-1511-ROVAS-2"],"award-info":[{"award-number":["TMA2016SF-1511-ROVAS-2"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["211356\/Z\/18\/Z"],"award-info":[{"award-number":["211356\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Oral rotavirus vaccines demonstrate diminished immunogenicity in low-income settings where human cytomegalovirus infection is acquired early in childhood and modulates immunity. We hypothesized that human cytomegalovirus infection around the time of vaccination may influence immunogenicity. We measured plasma human cytomegalovirus-specific immunoglobulin M antibodies in rotavirus vaccinated infants from 6 weeks to 12 months old and compared rotavirus immunoglobulin A antibody titers between human cytomegalovirus seropositive and seronegative infants. There was no evidence of an association between human cytomegalovirus serostatus at 9 months and rotavirus-specific antibody titers at 12 months (geometric mean ratio 1.01, 95% CI: 0.70, 1.45; P\u2005=\u20050.976) or fold-increase in RV-IgA titer between 9 and 12 months (risk ratio 0.999, 95%CI: 0.66, 1.52; P\u2005=\u20050.995) overall. However, HIV-exposed-uninfected infants who were seropositive for human cytomegalovirus at 9 months old had a 63% reduction in rotavirus antibody geometric mean titers at 12 months compared to HIV-exposed-uninfected infants who were seronegative for human cytomegalovirus (geometric mean ratio 0.37, 95% CI: 0.17, 0.77; P\u2005=\u20050.008). While the broader implications of human cytomegalovirus infections on oral rotavirus vaccine response might be limited in the general infant population, the potential impact in the HIV-exposed-uninfected infants cannot be overlooked. This study highlights the complexity of immunological responses and the need for targeted interventions to ensure oral rotavirus vaccine efficacy, especially in vulnerable subpopulations.<\/jats:p>","DOI":"10.1093\/cei\/uxae029","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T11:53:29Z","timestamp":1711626809000},"page":"99-108","source":"Crossref","is-referenced-by-count":1,"title":["Human cytomegalovirus seropositivity and its influence on oral rotavirus vaccine immunogenicity: a specific concern for HIV-exposed-uninfected infants"],"prefix":"10.1093","volume":"217","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6217-0289","authenticated-orcid":false,"given":"Natasha","family":"Laban","sequence":"first","affiliation":[{"name":"Enteric Disease and Vaccine Research Unit, Centre for Infectious Disease Research in Zambia , Lusaka , Zambia"},{"name":"Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Bosomprah","sequence":"additional","affiliation":[{"name":"Enteric Disease and Vaccine Research Unit, Centre for Infectious Disease Research in Zambia , Lusaka , Zambia"},{"name":"Department of Biostatistics, School of Public Health, University of Ghana , Accra , Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roma","family":"Chilengi","sequence":"additional","affiliation":[{"name":"Enteric Disease and Vaccine Research Unit, Centre for Infectious Disease Research in Zambia , Lusaka , Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelo","family":"Simuyandi","sequence":"additional","affiliation":[{"name":"Enteric Disease and Vaccine Research Unit, Centre for Infectious Disease Research in Zambia , Lusaka , Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Chisenga","sequence":"additional","affiliation":[{"name":"Enteric Disease and Vaccine Research Unit, Centre for Infectious Disease Research in Zambia , Lusaka , Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Ng\u2019ombe","sequence":"additional","affiliation":[{"name":"Enteric Disease and Vaccine Research Unit, Centre for Infectious Disease Research in Zambia , Lusaka , Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalo","family":"Musukuma-Chifulo","sequence":"additional","affiliation":[{"name":"Enteric Disease and Vaccine Research Unit, Centre for Infectious Disease Research in Zambia , Lusaka , Zambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Goodier","sequence":"additional","affiliation":[{"name":"Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine , London , UK"},{"name":"Flow Cytometry and Immunology Facility, Medical Research Council Unit, The Gambia at London School of Hygiene and Tropical Medicine , Fajara, Banjul , The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"2024062013071995800_CIT0001","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S1473-3099(18)30362-1","article-title":"Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"Troeger","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2024062013071995800_CIT0002","first-page":"CD008521","article-title":"Vaccines for preventing rotavirus diarrhoea: vaccines in use","volume":"11","author":"Bergman","year":"2021","journal-title":"Cochrane Database Syst 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