{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:55:27Z","timestamp":1791644127177,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Region Stockholm (SLL) through a clinical researcher position to EAB","award":["FoUI-954341"],"award-info":[{"award-number":["FoUI-954341"]}]},{"name":"Swedish Patent Revenue Fund, and the Center for Innovative Medicine","award":["FoUI-954540"],"award-info":[{"award-number":["FoUI-954540"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peri-implantitis (PI) and periodontitis (PD) are common oral inflammatory diseases, which seem to exhibit critical differences in some of their molecular features. Thus, we assessed the immune cell composition of PI and PD lesions and the corresponding inflammatory profile in soft tissues and crevicular fluid. PI, PD, and control patients were recruited (n\u2005=\u200562), and soft tissue biopsies were collected during surgery. Crevicular fluid around implant or tooth was collected. The proportions of major immune cell populations in tissues were analyzed by flow cytometry, and the inflammatory profile in tissue and crevicular fluid by a multiplex immunoassay. No significant difference was seen between PI and PD lesions in the proportions of immune cells. PI tissues showed an increased frequency of B cells in comparison with control tissues, along with higher levels of IL-1\u03b2, TNF-\u03b1, IL-4, and BAFF in tissue and crevicular fluid. Moreover, TNF-\u03b1, IL-17A, and BAFF were higher in PI tissues, but not in PD, than in control tissues. The immune cell composition did not differ significantly between PI and PD, but an enhanced inflammatory profile was seen in PI tissue. PI lesions were enriched in B cells, and displayed increased levels of IL-1\u03b2, TNF-\u03b1, IL-4, and BAFF in both tissue and crevicular fluid.<\/jats:p>","DOI":"10.1093\/cei\/uxae033","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T10:56:18Z","timestamp":1712919378000},"page":"173-182","source":"Crossref","is-referenced-by-count":27,"title":["Immune cell composition and inflammatory profile of human peri-implantitis and periodontitis lesions"],"prefix":"10.1093","volume":"217","author":[{"given":"Sebastian","family":"Malmqvist","sequence":"first","affiliation":[{"name":"Division of Oral Health and Periodontology, Department of Dental Medicine, Karolinska Institutet , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuben","family":"Clark","sequence":"additional","affiliation":[{"name":"Division of Oral Diagnostics and Surgery, Department of Dental Medicine, Karolinska Institutet , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Johannsen","sequence":"additional","affiliation":[{"name":"Division of Oral Health and Periodontology, Department of Dental Medicine, Karolinska Institutet , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annsofi","family":"Johannsen","sequence":"additional","affiliation":[{"name":"Division of Oral Health and Periodontology, Department of Dental Medicine, Karolinska Institutet , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth A","family":"Bostr\u00f6m","sequence":"additional","affiliation":[{"name":"Division of Oral Diagnostics and Surgery, Department of Dental Medicine, Karolinska Institutet , Stockholm , Sweden"},{"name":"Department of Orofacial Medicine, Folktandva\u030arden Stockholms La\u0308n AB , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0297-5138","authenticated-orcid":false,"given":"Ronaldo","family":"Lira-Junior","sequence":"additional","affiliation":[{"name":"Division of Oral Diagnostics and Surgery, Department of Dental Medicine, Karolinska Institutet , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"2024071204032001700_CIT0001","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1177\/0022034520920577","article-title":"Niche specific microbiota-dependent and independent bone loss around dental implants and teeth","volume":"99","author":"Heyman","year":"2020","journal-title":"J Dent Res"},{"key":"2024071204032001700_CIT0002","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/mi.2015.136","article-title":"Characterization of the human immune cell network at the gingival 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