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As the starting point for the activation of numerous signaling pathways, IL-22 plays an important role in the initiation and development of autoimmune diseases. Specifically, imbalances in IL-22 signaling can interfere with other signaling pathways, causing cross-regulation of target genes which ultimately leads to the development of immune disorders. This review delineates the various connections between the IL-22 signaling pathway and autoimmune disease, focusing on the latest understanding of the cellular sources of IL-22 and its effects on various cell types. We further explore progress with pharmacological interventions related to targeting IL-22, describing how such therapeutic strategies promise to usher in a new era in the treatment of autoimmune disease.<\/jats:p>","DOI":"10.1093\/cei\/uxae035","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T19:11:39Z","timestamp":1713553899000},"page":"242-263","source":"Crossref","is-referenced-by-count":20,"title":["IL-22, a vital cytokine in autoimmune diseases"],"prefix":"10.1093","volume":"218","author":[{"given":"Jiajin","family":"Li","sequence":"first","affiliation":[{"name":"The Second Clinical School of Medicine, Anhui Medical University , Hefei ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Clinical School of Medicine, Anhui Medical University , Hefei 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