{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:29:16Z","timestamp":1789248556086,"version":"build-2803163510"},"reference-count":136,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>CD8 T cells are crucial adaptive immune cells with cytotoxicity to fight against pathogens or abnormal self-cells via major histocompatibility complex class I-dependent priming pathways. The composition of the memory CD8 T-cell pool is influenced by various factors. Physiological aging, chronic viral infection, and autoimmune diseases promote the accumulation of CD8 T cells with highly differentiated memory phenotypes. Accumulating studies have shown that some of these memory CD8 T cells also exhibit innate-like cytotoxicity and upregulate the expression of receptors associated with natural killer (NK) cells. Further analysis shows that these NK-like CD8 T cells have transcriptional profiles of both NK and CD8 T cells, suggesting the transformation of CD8 T cells into NK cells. However, the specific induction mechanism underlying NK-like transformation and the implications of this process for CD8 T cells are still unclear. This review aimed to deduce the possible differentiation model of NK-like CD8 T cells, summarize the functions of major NK-cell receptors expressed on these cells, and provide a new perspective for exploring the role of these CD8 T cells in health and disease.<\/jats:p>","DOI":"10.1093\/cei\/uxae038","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T09:30:18Z","timestamp":1713778218000},"page":"136-150","source":"Crossref","is-referenced-by-count":19,"title":["NK-like CD8 T cell: one potential evolutionary continuum between adaptive memory and innate immunity"],"prefix":"10.1093","volume":"217","author":[{"given":"Qiulei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Medicine, Jiangsu University , Zhenjiang , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaodan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Jiangsu University , Zhenjiang , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhong","family":"Guo","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0663-6988","authenticated-orcid":false,"given":"Sheng","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine, Jiangsu University , Zhenjiang , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, Tsinghua University , Beijing , 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