{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:58:10Z","timestamp":1789495090457,"version":"build-2803163510"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Peer Reviewed Medical Research Program","award":["W81XWH-15-1-0003"],"award-info":[{"award-number":["W81XWH-15-1-0003"]}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["75N93019C00068"],"award-info":[{"award-number":["75N93019C00068"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Rheumatoid arthritis (RA) is associated with high-risk HLA class II alleles known as the \u201cRA shared epitope.\u201d Among prevalent shared epitope alleles, study of DRB1*04:04 has been limited. To define relevant epitopes, we identified citrullinated peptide sequences from synovial antigens that were predicted to bind to HLA-DRB1*04:04 and utilized a systematic approach to confirm their binding and assess their recognition by CD4 T cells. After confirming the immunogenicity of 13 peptides derived from aggrecan, cartilage intermediate layer protein (CILP), \u03b1-enolase, vimentin, and fibrinogen, we assessed their recognition by T cells from a synovial tissue sample, observing measurable responses to 8 of the 13 peptides. We then implemented a multicolor tetramer panel to evaluate the frequency and phenotype of antigen-specific CD4 T cells in individuals with anti-citrullinated protein antibody-positive RA and controls. In subjects with RA, CILP-specific T-cell frequencies were significantly higher than those of other antigens. The surface phenotypes exhibited by antigen-specific T cells were heterogeneous, but Th1-like and Th2-like cells predominated. Stratifying based on disease status and activity, antigen-specific T cells were more frequent and most strongly polarized in RA subjects with high disease activity. In total, these findings identify novel citrullinated epitopes that can be used to interrogate antigen-specific CD4 T cells and show that antigen-specific T-cell frequency is elevated in subjects with high disease activity.<\/jats:p>","DOI":"10.1093\/cei\/uxae102","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T08:45:31Z","timestamp":1730709931000},"source":"Crossref","is-referenced-by-count":6,"title":["Antigen-specific T-cell frequency and phenotype mirrors disease activity in DRB1*04:04+ rheumatoid arthritis patients"],"prefix":"10.1093","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0342-4378","authenticated-orcid":false,"given":"Cliff","family":"Rims","sequence":"first","affiliation":[{"name":"Center for Translational Immunology, Benaroya Research Institute at Virginia Mason , Seattle, WA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Uchtenhagen","sequence":"additional","affiliation":[{"name":"Center for Translational Immunology, Benaroya Research Institute at Virginia Mason , Seattle, WA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadin","family":"Brooks","sequence":"additional","affiliation":[{"name":"Center for Translational Immunology, Benaroya Research Institute at Virginia Mason , Seattle, WA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Ng","sequence":"additional","affiliation":[{"name":"VA National Rheumatology Program, Specialty Care Program Office , Washington DC ,","place":["USA"]},{"name":"Department of Medicine, Division of Rheumatology, University of Washington , Seattle, WA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6572-4291","authenticated-orcid":false,"given":"Sylvia E","family":"Posso","sequence":"additional","affiliation":[{"name":"Center for Translational Immunology, Benaroya Research Institute at Virginia Mason , Seattle, WA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5634-1981","authenticated-orcid":false,"given":"Jeffrey","family":"Carlin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Virginia Mason Medical Center , Seattle, WA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4843-4599","authenticated-orcid":false,"given":"William W","family":"Kwok","sequence":"additional","affiliation":[{"name":"Center for Translational Immunology, Benaroya Research Institute at Virginia Mason , Seattle, WA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9005-1885","authenticated-orcid":false,"given":"Jane H","family":"Buckner","sequence":"additional","affiliation":[{"name":"Center for Translational Immunology, Benaroya Research Institute at Virginia Mason , Seattle, WA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7217-5729","authenticated-orcid":false,"given":"Eddie A","family":"James","sequence":"additional","affiliation":[{"name":"Center for Translational Immunology, Benaroya Research Institute at Virginia Mason , Seattle, WA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"2025041017540548800_CIT0001","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1002\/art.1780301102","article-title":"The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis","volume":"30","author":"Gregersen","year":"1987","journal-title":"Arthritis Rheum"},{"key":"2025041017540548800_CIT0002","doi-asserted-by":"publisher","first-page":"R784","DOI":"10.1186\/ar1733","article-title":"Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin","volume":"7","author":"Raza","year":"2005","journal-title":"Arthritis Research & Therapy"},{"key":"2025041017540548800_CIT0003","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"key":"2025041017540548800_CIT0004","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1056\/NEJMoa035075","article-title":"Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig","volume":"349","author":"Kremer","year":"2003","journal-title":"N Engl J Med"},{"key":"2025041017540548800_CIT0005","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1056\/NEJM197804202981602","article-title":"Association of the B-cell alloantigen DRw4 with rheumatoid arthritis","volume":"298","author":"Stastny","year":"1978","journal-title":"N Engl J Med"},{"key":"2025041017540548800_CIT0006","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ng.1076","article-title":"Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis","volume":"44","author":"Raychaudhuri","year":"2012","journal-title":"Nat Genet"},{"key":"2025041017540548800_CIT0007","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1136\/ard.2009.126821","article-title":"A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis","volume":"70","author":"Padyukov","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"2025041017540548800_CIT0008","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1002\/art.20553","article-title":"A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis","volume":"50","author":"Padyukov","year":"2004","journal-title":"Arthritis Rheum"},{"key":"2025041017540548800_CIT0009","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1002\/art.39228","article-title":"Interactions between amino acid-defined major histocompatibility complex class II variants and smoking in seropositive rheumatoid arthritis","volume":"67","author":"Kim","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"2025041017540548800_CIT0010","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1172\/JCI115814","article-title":"Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis","volume":"89","author":"Weyand","year":"1992","journal-title":"J Clin Invest"},{"key":"2025041017540548800_CIT0011","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1172\/JCI117900","article-title":"Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis","volume":"95","author":"Weyand","year":"1995","journal-title":"J Clin Invest"},{"key":"2025041017540548800_CIT0012","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jaut.2018.04.004","article-title":"Memory T cells specific to citrullinated alpha-enolase are enriched in the rheumatic joint","volume":"92","author":"Pieper","year":"2018","journal-title":"J Autoimmun"},{"key":"2025041017540548800_CIT0013","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1007\/s00296-013-2731-2","article-title":"T cell responses to citrullinated self-peptides in patients with rheumatoid arthritis","volume":"33","author":"Aggarwal","year":"2013","journal-title":"Rheumatol Int"},{"key":"2025041017540548800_CIT0014","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1002\/art.38637","article-title":"Citrulline-specific Th1 cells are increased in rheumatoid arthritis and their frequency is influenced by disease duration and therapy","volume":"66","author":"James","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"2025041017540548800_CIT0015","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1002\/art.39553","article-title":"A novel HLA-DRB1*10:01-restricted T cell epitope from citrullinated type II collagen relevant to rheumatoid arthritis","volume":"68","author":"Chemin","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2025041017540548800_CIT0016","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1186\/ar3848","article-title":"T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles","volume":"14","author":"Law","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"2025041017540548800_CIT0017","doi-asserted-by":"publisher","first-page":"e145217","DOI":"10.1172\/jci.insight.145217","article-title":"Shared recognition of citrullinated tenascin-C peptides by T and B cells in rheumatoid arthritis","volume":"6","author":"Song","year":"2021","journal-title":"JCI Insight"},{"key":"2025041017540548800_CIT0018","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12865-020-00357-w","article-title":"Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis","volume":"21","author":"Gerstner","year":"2020","journal-title":"BMC Immunol"},{"key":"2025041017540548800_CIT0019","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1002\/art.41157","article-title":"CD4+ Memory Stem T Cells recognizing citrullinated epitopes are expanded in patients with rheumatoid arthritis and sensitive to tumor necrosis factor blockade","volume":"72","author":"Cianciotti","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"2025041017540548800_CIT0020","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3389\/fimmu.2016.00494","article-title":"Functional and structural characterization of a novel HLA-DRB1*04:01-restricted alpha-enolase T cell epitope in rheumatoid arthritis","volume":"7","author":"Gerstner","year":"2016","journal-title":"Front Immunol"},{"key":"2025041017540548800_CIT0021","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1084\/jem.20072051","article-title":"Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice","volume":"205","author":"Hill","year":"2008","journal-title":"J Exp Med"},{"key":"2025041017540548800_CIT0022","doi-asserted-by":"publisher","first-page":"538","DOI":"10.4049\/jimmunol.171.2.538","article-title":"Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule","volume":"171","author":"Hill","year":"2003","journal-title":"J Immunol"},{"key":"2025041017540548800_CIT0023","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.4049\/jimmunol.1201517","article-title":"A citrullinated fibrinogen-specific T cell line enhances autoimmune arthritis in a mouse model of rheumatoid arthritis","volume":"190","author":"Cordova","year":"2013","journal-title":"J Immunol"},{"key":"2025041017540548800_CIT0024","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.intimp.2012.05.007","article-title":"Citrullinated mouse collagen administered to DBA\/1J mice in the absence of adjuvant initiates arthritis","volume":"13","author":"Thiele","year":"2012","journal-title":"Int Immunopharmacol"},{"key":"2025041017540548800_CIT0025","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1002\/art.40768","article-title":"Citrullinated aggrecan epitopes as targets of autoreactive CD4+ T cells in patients with rheumatoid arthritis","volume":"71","author":"Rims","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"2025041017540548800_CIT0026","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1002\/art.30445","article-title":"Identification and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1*0401-positive humanized mice and rheumatoid arthritis patients","volume":"63","author":"Snir","year":"2011","journal-title":"Arthritis Rheum"},{"key":"2025041017540548800_CIT0027","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1136\/ard.48.5.406","article-title":"DR4 prevalence related to the age at disease onset in female patients with rheumatoid arthritis","volume":"48","author":"Hazes","year":"1989","journal-title":"Ann Rheum Dis"},{"key":"2025041017540548800_CIT0028","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.1002\/art.20469","article-title":"The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept","volume":"50","author":"Criswell","year":"2004","journal-title":"Arthritis Rheum"},{"key":"2025041017540548800_CIT0029","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1517\/17425255.2014.970165","article-title":"Pharmacogenetics of etanercept: role of TNF-\u03b1 gene polymorphisms in improving its efficacy","volume":"10","author":"Murdaca","year":"2014","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"2025041017540548800_CIT0030","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/s1074-7613(00)80369-6","article-title":"X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II","volume":"7","author":"Dessen","year":"1997","journal-title":"Immunity"},{"key":"2025041017540548800_CIT0031","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/0925-4439(96)00010-5","article-title":"Natural ligand motifs of closely related HLA-DR4 molecules predict features of rheumatoid arthritis associated peptides","volume":"1316","author":"Friede","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"2025041017540548800_CIT0032","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1002\/art.27594","article-title":"HLA\u2013DR1001 presents \u201caltered-self\u201d peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets","volume":"62","author":"James","year":"2010","journal-title":"Arthritis Rheum"},{"key":"2025041017540548800_CIT0033","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/s0198-8859(99)00037-3","article-title":"CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes. Implications for HLA class I and II allelic linkage to disease susceptibility","volume":"60","author":"Ou","year":"1999","journal-title":"Hum Immunol"},{"key":"2025041017540548800_CIT0034","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.2337\/dbi19-0022","article-title":"T-cell epitopes and neo-epitopes in type 1 diabetes: a comprehensive update and reappraisal","volume":"69","author":"James","year":"2020","journal-title":"Diabetes"},{"key":"2025041017540548800_CIT0035","doi-asserted-by":"publisher","first-page":"R63","DOI":"10.1172\/JCI8476","article-title":"MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen","volume":"104","author":"Novak","year":"1999","journal-title":"J Clin Invest"},{"key":"2025041017540548800_CIT0036","doi-asserted-by":"publisher","first-page":"7637","DOI":"10.1038\/s41467-023-43091-8","article-title":"Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis","volume":"14","author":"James","year":"2023","journal-title":"Nat Commun"},{"key":"2025041017540548800_CIT0037","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.4049\/jimmunol.1102190","article-title":"Frequency of epitope-specific naive CD4(+) T cells correlates with immunodominance in the human memory repertoire","volume":"188","author":"Kwok","year":"2012","journal-title":"J Immunol"},{"key":"2025041017540548800_CIT0038","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1172\/JCI126595","article-title":"Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression","volume":"130","author":"Wiedeman","year":"2020","journal-title":"J Clin Invest"},{"key":"2025041017540548800_CIT0039","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1210\/clinem\/dgad434","article-title":"Technical validation and utility of an HLA class II tetramer assay for type 1 diabetes: a multicenter study","volume":"109","author":"Ettinger","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"2025041017540548800_CIT0040","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.cellimm.2018.11.004","article-title":"Analysis of pancreatic beta cell specific CD4+ T cells reveals a predominance of proinsulin specific cells","volume":"335","author":"Blahnik","year":"2019","journal-title":"Cell Immunol"},{"key":"2025041017540548800_CIT0041","doi-asserted-by":"publisher","first-page":"12614","DOI":"10.1038\/ncomms12614","article-title":"Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining","volume":"7","author":"Uchtenhagen","year":"2016","journal-title":"Nat Commun"},{"key":"2025041017540548800_CIT0042","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.4049\/jimmunol.180.3.1758","article-title":"Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus","volume":"180","author":"Roti","year":"2008","journal-title":"J Immunol"},{"key":"2025041017540548800_CIT0043","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1126\/science.1260668","article-title":"T cell immunity. Functional heterogeneity of human memory CD4(+) T cell clones primed by pathogens or vaccines","volume":"347","author":"Becattini","year":"2015","journal-title":"Science"},{"key":"2025041017540548800_CIT0044","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1146\/annurev-immunol-032414-112056","article-title":"Heterogeneity of human CD4(+) T cells against microbes","volume":"34","author":"Sallusto","year":"2016","journal-title":"Annu Rev Immunol"},{"key":"2025041017540548800_CIT0045","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1093\/rheumatology\/kem364","article-title":"An index of only patient-reported outcome measures, routine assessment of patient index data 3 (RAPID3), in two abatacept clinical trials: similar results to disease activity score (DAS28) and other RAPID indices that include physician-reported measures","volume":"47","author":"Pincus","year":"2008","journal-title":"Rheumatol"},{"key":"2025041017540548800_CIT0046","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.3899\/jrheum.080182","article-title":"RAPID3 (Routine Assessment of Patient Index Data 3), a rheumatoid arthritis index without formal joint counts for routine care: proposed severity categories compared to disease activity score and clinical disease activity index categories","volume":"35","author":"Pincus","year":"2008","journal-title":"J Rheumatol"},{"key":"2025041017540548800_CIT0047","doi-asserted-by":"publisher","first-page":"e64108","DOI":"10.1371\/journal.pone.0064108","article-title":"HLA-DRB1 genotypes and the risk of developing anti citrullinated protein antibody (ACPA) positive rheumatoid arthritis","volume":"8","author":"Balandraud","year":"2013","journal-title":"PLoS One"},{"key":"2025041017540548800_CIT0048","first-page":"627","article-title":"HLA-DRB1*0404 is strongly associated with high titers of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis","volume":"26","author":"Charpin","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"2025041017540548800_CIT0049","first-page":"1032","article-title":"HLA-DRB1*0401\/0404 genotype and rheumatoid arthritis: increased association in men, young age at onset, and disease severity","volume":"22","author":"MacGregor","year":"1995","journal-title":"J Rheumatol"},{"key":"2025041017540548800_CIT0050","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.rdc.2017.04.003","article-title":"Human leukocyte antigen-disease associations in rheumatoid arthritis","volume":"43","author":"van Drongelen","year":"2017","journal-title":"Rheum Dis Clin North Am"},{"key":"2025041017540548800_CIT0051","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1302\/2046-3758.117.BJR-2021-0594.R1","article-title":"Immunomodulatory role of T helper cells in rheumatoid arthritis: a comprehensive research review","volume":"11","author":"Luo","year":"2022","journal-title":"Bone Joint Res"},{"key":"2025041017540548800_CIT0052","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1084\/jem.20071397","article-title":"Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model","volume":"204","author":"Hirota","year":"2007","journal-title":"J Exp Med"},{"key":"2025041017540548800_CIT0053","doi-asserted-by":"publisher","first-page":"e1112","DOI":"10.1002\/iid3.1112","article-title":"Increased gene expression of CCR6 and ROR\u03b3t in peripheral blood cells of rheumatoid arthritis patients and their correlation with anti-cyclic citrullinated peptide and disease activity","volume":"11","author":"Roghani","year":"2023","journal-title":"Immun Inflamm Dis"},{"key":"2025041017540548800_CIT0054","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature20810","article-title":"Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis","volume":"542","author":"Rao","year":"2017","journal-title":"Nature"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cei\/advance-article-pdf\/doi\/10.1093\/cei\/uxae102\/60936174\/uxae102.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/219\/1\/uxae102\/60936174\/uxae102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/219\/1\/uxae102\/60936174\/uxae102.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T17:54:23Z","timestamp":1744307663000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/doi\/10.1093\/cei\/uxae102\/7874388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,4]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,21]]}},"URL":"https:\/\/doi.org\/10.1093\/cei\/uxae102","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2024,11,4]]},"article-number":"uxae102"}}