{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:17:08Z","timestamp":1782782228228,"version":"3.54.5"},"reference-count":116,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Trinity College Dublin School of Medicine and Trinity Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neutrophils are short-lived cells of the innate immune system and represent 50\u201370% of the circulating leucocytes. Their primary role is antimicrobial defence which they accomplish through rapid migration to sites of inflammation followed by phagocytosis, degranulation, and the release of neutrophil extracellular traps (NETosis). While previously considered terminally differentiated cells, they have been shown to have great adaptability and to play a role in conditions ranging from cancer to autoimmunity. This review focuses on their role in allergic disease. In particular: their role as potential amplifiers of type 1 hypersensitivity reactions leading to anaphylaxis; their involvement in alternative pathways of food and drug allergy; their role in allergic rhinitis and asthma and neutrophil dysfunction in atopic dermatitis. The use of potential biomarkers and therapeutic targets is also discussed with a view to guiding future research.<\/jats:p>","DOI":"10.1093\/cei\/uxae126","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T03:32:31Z","timestamp":1735183951000},"source":"Crossref","is-referenced-by-count":12,"title":["The role of neutrophils in allergic disease"],"prefix":"10.1093","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9998-9976","authenticated-orcid":false,"given":"James","family":"Trayer","sequence":"first","affiliation":[{"name":"Discipline of Paediatrics, School of Medicine, Trinity College Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johana","family":"Isaza-Correa","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics, School of Medicine, Trinity College Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4782-1143","authenticated-orcid":false,"given":"Lynne","family":"Kelly","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics, School of Medicine, Trinity College Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeve","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Department of Allergy, Children\u2019s Health Ireland at Crumlin , Dublin ,\u00a0","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Hourihane","sequence":"additional","affiliation":[{"name":"Department of Allergy, Children\u2019s Health Ireland at Temple Street , Dublin ,\u00a0","place":["Ireland"]},{"name":"Paediatrics and Child Health, Royal College of Surgeons in Ireland , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aideen","family":"Byrne","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics, School of Medicine, Trinity College Dublin ,","place":["Ireland"]},{"name":"Department of Allergy, Children\u2019s Health Ireland at Crumlin , Dublin ,\u00a0","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Molloy","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics, School of Medicine, Trinity College Dublin ,","place":["Ireland"]},{"name":"Department of Neurodisability, Children\u2019s Health Ireland at Tallaght , Dublin ,\u00a0","place":["Ireland"]},{"name":"Paediatrics, Coombe Hospital , Dublin ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"2025041017392149900_CIT0001","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1399-3038.2007.00601.x","article-title":"Worldwide time trends for symptoms of rhinitis and conjunctivitis: phase III of the International Study of Asthma and Allergies in Childhood","volume":"19","author":"Bjorksten","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"2025041017392149900_CIT0002","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/S0140-6736(06)69283-0","article-title":"Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys","volume":"368","author":"Asher","year":"2006","journal-title":"Lancet"},{"key":"2025041017392149900_CIT0003","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1111\/all.15902","article-title":"EAACI guidelines on the diagnosis of IgE-mediated food allergy","volume":"78","author":"Santos","year":"2023","journal-title":"Allergy"},{"key":"2025041017392149900_CIT0004","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1111\/all.12470","article-title":"Economic burden of inadequate management of allergic diseases in the European Union: a GA(2) LEN review","volume":"69","author":"Zuberbier","year":"2014","journal-title":"Allergy"},{"key":"2025041017392149900_CIT0005","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.jaci.2007.03.034","article-title":"Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: case-control study","volume":"120","author":"Walker","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0006","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1056\/NEJMra1011040","article-title":"Filaggrin mutations associated with skin and allergic diseases","volume":"365","author":"Irvine","year":"2011","journal-title":"N Engl J Med"},{"key":"2025041017392149900_CIT0007","doi-asserted-by":"publisher","first-page":"138","DOI":"10.2500\/aap.2019.40.4217","article-title":"Role of innate lymphoid cells in allergic diseases","volume":"40","author":"Pasha","year":"2019","journal-title":"Allergy Asthma Proc"},{"key":"2025041017392149900_CIT0008","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41577-022-00735-y","article-title":"Role of thymic stromal lymphopoietin in allergy and beyond","volume":"23","author":"Ebina-Shibuya","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"2025041017392149900_CIT0009","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jaci.2011.08.031","article-title":"Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma","volume":"129","author":"Shikotra","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0010","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1056\/NEJMoa2034975","article-title":"Tezepelumab in adults and adolescents with severe, uncontrolled asthma","volume":"384","author":"Menzies-Gow","year":"2021","journal-title":"N Engl J Med"},{"key":"2025041017392149900_CIT0011","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3389\/fphys.2018.00113","article-title":"Neutrophil: a cell with many roles in inflammation or several cell types","volume":"9","author":"Rosales","year":"2018","journal-title":"Front Physiol"},{"key":"2025041017392149900_CIT0012","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3390\/ijms21010287","article-title":"Neutrophil metabolic shift during their lifecycle: impact on their survival and activation","volume":"21","author":"Injarabian","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2025041017392149900_CIT0013","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.3390\/v13112318","article-title":"The roles of neutrophils in cytokine storms","volume":"13","author":"Chan","year":"2021","journal-title":"Viruses"},{"key":"2025041017392149900_CIT0014","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1160\/TH08-12-0844","article-title":"Novel aspects in the regulation of the leukocyte adhesion cascade","volume":"102","author":"Chavakis","year":"2009","journal-title":"Thromb Haemost"},{"key":"2025041017392149900_CIT0015","doi-asserted-by":"publisher","first-page":"eaat4579","DOI":"10.1126\/sciimmunol.aat4579","article-title":"Neutrophils: new insights and open questions","volume":"3","author":"Ley","year":"2018","journal-title":"Sci Immunol"},{"key":"2025041017392149900_CIT0016","doi-asserted-by":"publisher","first-page":"8057","DOI":"10.3390\/ijms21218057","article-title":"The dual role of myeloperoxidase in immune response","volume":"21","author":"Arnhold","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2025041017392149900_CIT0017","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jaci.2012.08.016","article-title":"Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis","volume":"131","author":"Vadas","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0018","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1002\/biof.1883","article-title":"Platelet Activating Factor (PAF): a mediator of inflammation","volume":"48","author":"Upton","year":"2022","journal-title":"Biofactors"},{"key":"2025041017392149900_CIT0019","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.1182\/blood-2016-03-700336","article-title":"Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives","volume":"127","author":"Lahoz-Beneytez","year":"2016","journal-title":"Blood"},{"key":"2025041017392149900_CIT0020","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.it.2011.01.001","article-title":"Regulating neutrophil apoptosis: new players enter the game","volume":"32","author":"Witko-Sarsat","year":"2011","journal-title":"Trends Immunol"},{"key":"2025041017392149900_CIT0021","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: challenges and opportunities","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"2025041017392149900_CIT0022","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptive immunity","volume":"11","author":"Mantovani","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"2025041017392149900_CIT0023","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.3389\/fimmu.2017.01781","article-title":"Granulocytes: new members of the antigen-presenting cell family","volume":"8","author":"Lin","year":"2017","journal-title":"Front Immunol"},{"key":"2025041017392149900_CIT0024","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.jaci.2018.06.005","article-title":"A novel role for neutrophils in IgE-mediated allergy: evidence for antigen presentation in late-phase reactions","volume":"143","author":"Polak","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0025","doi-asserted-by":"publisher","first-page":"602963","DOI":"10.3389\/fimmu.2021.602963","article-title":"Neutrophils: need for Standardized Nomenclature","volume":"12","author":"McKenna","year":"2021","journal-title":"Front Immunol"},{"key":"2025041017392149900_CIT0026","volume-title":"Clinical Aspects of Immunology","author":"Gell P.G.H CRRA","year":"1963"},{"key":"2025041017392149900_CIT0027","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1111\/all.15889","article-title":"Nomenclature of allergic diseases and hypersensitivity reactions: adapted to modern needs: an EAACI position paper","volume":"78","author":"Jutel","year":"2023","journal-title":"Allergy"},{"key":"2025041017392149900_CIT0028","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/all.15032","article-title":"EAACI guidelines: anaphylaxis (2021 update)","volume":"77","author":"Muraro","year":"2022","journal-title":"Allergy"},{"key":"2025041017392149900_CIT0029","doi-asserted-by":"publisher","first-page":"620","DOI":"10.3389\/fimmu.2015.00620","article-title":"Mast cell: a multi-functional master cell","volume":"6","author":"Krystel-Whittemore","year":"2015","journal-title":"Front Immunol"},{"key":"2025041017392149900_CIT0030","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ejphar.2015.07.017","article-title":"Non-IgE mediated mast cell activation","volume":"778","author":"Yu","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"2025041017392149900_CIT0031","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1111\/cea.12477","article-title":"Incidence of food anaphylaxis in people with food allergy: a systematic review and meta-analysis","volume":"45","author":"Umasunthar","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"2025041017392149900_CIT0032","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1038\/s41467-017-02188-7","article-title":"Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions","volume":"8","author":"Watson","year":"2017","journal-title":"Nat Commun"},{"key":"2025041017392149900_CIT0033","doi-asserted-by":"publisher","first-page":"1016165","DOI":"10.3389\/fimmu.2022.1016165","article-title":"Integrative transcriptomic analysis in human and mouse model of anaphylaxis identifies gene signatures associated with cell movement, migration and neuroinflammatory signalling","volume":"13","author":"Rijavec","year":"2022","journal-title":"Front Immunol"},{"key":"2025041017392149900_CIT0034","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/ped.13728","article-title":"Neutrophilia and hyperamylasemia in patients with immediate food allergy","volume":"61","author":"Kimura","year":"2019","journal-title":"Pediatr Int"},{"key":"2025041017392149900_CIT0035","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/j.jaci.2023.12.028","article-title":"Joint transcriptomic and cytometric study of children with peanut allergy reveals molecular and cellular cross talk in reaction thresholds","volume":"153","author":"Zhang","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0036","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/cea.12868","article-title":"Neutrophil activation during acute human anaphylaxis: analysis of MPO and sCD62L","volume":"47","author":"Francis","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"2025041017392149900_CIT0037","doi-asserted-by":"publisher","first-page":"102109","DOI":"10.1016\/j.redox.2021.102109","article-title":"The many roles of myeloperoxidase: from inflammation and immunity to biomarkers, drug metabolism and drug discovery","volume":"46","author":"Siraki","year":"2021","journal-title":"Redox Biol"},{"key":"2025041017392149900_CIT0038","doi-asserted-by":"publisher","first-page":"e101409","DOI":"10.1371\/journal.pone.0101409","article-title":"Genomic responses during acute human anaphylaxis are characterized by upregulation of innate inflammatory gene networks","volume":"9","author":"Stone","year":"2014","journal-title":"PLoS One"},{"key":"2025041017392149900_CIT0039","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1111\/cea.14273","article-title":"Acute systemic myeloid inflammatory and stress response in severe food allergic reactions","volume":"53","author":"Sharma","year":"2023","journal-title":"Clin Exp Allergy"},{"key":"2025041017392149900_CIT0040","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/j.jaci.2010.01.056","article-title":"Activation of human mast cells through the platelet-activating factor receptor","volume":"125","author":"Kajiwara","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0041","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1056\/NEJMoa070030","article-title":"Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis","volume":"358","author":"Vadas","year":"2008","journal-title":"N Engl J Med"},{"key":"2025041017392149900_CIT0042","doi-asserted-by":"publisher","first-page":"864387","DOI":"10.3389\/fimmu.2022.864387","article-title":"Neutrophils in COVID-19: not innocent bystanders","volume":"13","author":"McKenna","year":"2022","journal-title":"Front Immunol"},{"key":"2025041017392149900_CIT0043","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1111\/all.12924","article-title":"Can we identify patients at risk of life-threatening allergic reactions to food","volume":"71","author":"Turner","year":"2016","journal-title":"Allergy"},{"key":"2025041017392149900_CIT0044","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1096\/fj.00-0378com","article-title":"Human neutrophils express the high-affinity receptor for immunoglobulin E (Fc epsilon RI): role in asthma","volume":"15","author":"Gounni","year":"2001","journal-title":"FASEB J"},{"key":"2025041017392149900_CIT0045","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nri2206","article-title":"Fcgamma receptors as regulators of immune responses","volume":"8","author":"Nimmerjahn","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"2025041017392149900_CIT0046","doi-asserted-by":"publisher","first-page":"931","DOI":"10.3390\/biology12070931","article-title":"Animal models of IgE anaphylaxis","volume":"12","author":"Gouel-Cheron","year":"2023","journal-title":"Biology (Basel)"},{"key":"2025041017392149900_CIT0047","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.jaci.2013.06.008","article-title":"Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice","volume":"132","author":"Reber","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0048","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1182\/blood-2011-07-367334","article-title":"Human FcgammaRIIA induces anaphylactic and allergic reactions","volume":"119","author":"Jonsson","year":"2012","journal-title":"Blood"},{"key":"2025041017392149900_CIT0049","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1172\/JCI45232","article-title":"Mouse and human neutrophils induce anaphylaxis","volume":"121","author":"Jonsson","year":"2011","journal-title":"J Clin Invest"},{"key":"2025041017392149900_CIT0050","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/s0014-2999(97)01142-4","article-title":"Effects of neuropeptide FF on intestinal motility and temperature changes induced by endotoxin and platelet-activating factor","volume":"334","author":"Million","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"2025041017392149900_CIT0051","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/j.jaci.2016.06.048","article-title":"Mass cytometry profiling the response of basophils and the complete peripheral blood compartment to peanut","volume":"138","author":"Tordesillas","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0052","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1016\/j.jaci.2016.02.015","article-title":"Human IgE-independent systemic anaphylaxis","volume":"137","author":"Finkelman","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0053","doi-asserted-by":"publisher","first-page":"eaan5997","DOI":"10.1126\/sciimmunol.aan5997","article-title":"Platelets expressing IgG receptor FcgammaRIIA\/CD32A determine the severity of experimental anaphylaxis","volume":"3","author":"Beutier","year":"2018","journal-title":"Sci Immunol"},{"key":"2025041017392149900_CIT0054","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s00441-017-2727-4","article-title":"Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease","volume":"371","author":"Lisman","year":"2018","journal-title":"Cell Tissue Res"},{"key":"2025041017392149900_CIT0055","doi-asserted-by":"publisher","first-page":"e12010","DOI":"10.1002\/clt2.12010","article-title":"Non-specific lipid-transfer proteins: Allergen structure and function, cross-reactivity, sensitization, and epidemiology","volume":"11","author":"Skypala","year":"2021","journal-title":"Clin Transl Allergy"},{"key":"2025041017392149900_CIT0056","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/cea.14049","article-title":"Lipid transfer protein allergy: a review of current controversies","volume":"52","author":"Asero","year":"2022","journal-title":"Clin Exp Allergy"},{"key":"2025041017392149900_CIT0057","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1111\/all.14797","article-title":"The diagnosis and management of allergic reactions in patients sensitized to non-specific lipid transfer proteins","volume":"76","author":"Skypala","year":"2021","journal-title":"Allergy"},{"key":"2025041017392149900_CIT0058","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jaci.2015.05.042","article-title":"Distinct transcriptome profiles differentiate nonsteroidal anti-inflammatory drug-dependent from nonsteroidal anti-inflammatory drug-independent food-induced anaphylaxis","volume":"137","author":"Munoz-Cano","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0059","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jaci.2016.03.028","article-title":"IgG subclasses determine pathways of anaphylaxis in mice","volume":"139","author":"Beutier","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0060","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.anai.2021.02.006","article-title":"Food protein-induced enterocolitis syndrome epidemiology","volume":"126","author":"Cianferoni","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2025041017392149900_CIT0061","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.jaci.2016.12.966","article-title":"International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: executive summary\u2014Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology","volume":"139","author":"Nowak-Wegrzyn","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0062","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/s0022-3476(78)80887-7","article-title":"Milk- and soy-induced enterocolitis of infancy. Clinical features and standardization of challenge","volume":"93","author":"Powell","year":"1978","journal-title":"J Pediatr"},{"key":"2025041017392149900_CIT0063","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1016\/j.jaci.2016.12.971","article-title":"Systemic innate immune activation in food protein-induced enterocolitis syndrome","volume":"139","author":"Goswami","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0064","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.2500\/aap.2020.41.190017","article-title":"Predictors for late tolerance development in food protein-induced allergic proctocolitis","volume":"41","author":"Cetinkaya","year":"2020","journal-title":"Allergy Asthma Proc"},{"key":"2025041017392149900_CIT0065","doi-asserted-by":"publisher","first-page":"e024","DOI":"10.1097\/PG9.0000000000000024","article-title":"Outcomes of infants with severe refractory food protein-induced allergic proctocolitis treated with mesalamine","volume":"2","author":"Rojas Gallegos","year":"2021","journal-title":"JPGN Rep"},{"key":"2025041017392149900_CIT0066","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1111\/ped.12366","article-title":"Outcome of infants presenting rectal bleeding: a retrospective study in a single institution","volume":"56","author":"Mori","year":"2014","journal-title":"Pediatr Int"},{"key":"2025041017392149900_CIT0067","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1097\/PAS.0b013e318254f413","article-title":"Neutrophilic infiltration in gluten-sensitive enteropathy is neither uncommon nor insignificant: assessment of duodenal biopsies from 267 pediatric and adult patients","volume":"36","author":"Moran","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"2025041017392149900_CIT0068","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1097\/00130832-200406000-00004","article-title":"Mediators of inflammation in the early and the late phase of allergic rhinitis","volume":"4","author":"Hansen","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0069","doi-asserted-by":"publisher","first-page":"43568","DOI":"10.1038\/srep43568","article-title":"A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification","volume":"7","author":"Arebro","year":"2017","journal-title":"Sci Rep"},{"key":"2025041017392149900_CIT0070","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/0091-6749(94)90358-1","article-title":"The effect of immunotherapy on the cutaneous late phase response to antigen","volume":"93","author":"Nish","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0071","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1111\/j.1365-2222.2011.03804.x","article-title":"Mechanisms of immunotherapy to aeroallergens","volume":"41","author":"Shamji","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"2025041017392149900_CIT0072","doi-asserted-by":"publisher","first-page":"662378","DOI":"10.3389\/falgy.2021.662378","article-title":"Characterization of innate immune responses to house dust mite allergens: pitfalls and limitations","volume":"2","author":"Jacquet","year":"2021","journal-title":"Front Allergy"},{"key":"2025041017392149900_CIT0073","doi-asserted-by":"publisher","first-page":"8440","DOI":"10.3390\/ijms22168440","article-title":"Der f 38 is a novel TLR4-binding allergen related to allergy pathogenesis from Dermatophagoides farinae","volume":"22","author":"Kim","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025041017392149900_CIT0074","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s12026-015-8730-5","article-title":"House dust mite allergen suppresses neutrophil apoptosis by cytokine release via PAR2 in normal and allergic lymphocytes","volume":"64","author":"Lee","year":"2016","journal-title":"Immunol Res"},{"key":"2025041017392149900_CIT0075","doi-asserted-by":"publisher","first-page":"e0125983","DOI":"10.1371\/journal.pone.0125983","article-title":"House dust mite allergen regulates constitutive apoptosis of normal and asthmatic neutrophils via toll-like receptor 4","volume":"10","author":"Kim","year":"2015","journal-title":"PLoS One"},{"key":"2025041017392149900_CIT0076","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1111\/j.1365-2222.2009.03291.x","article-title":"Timothy grass pollen major allergen Phl p 1 activates respiratory epithelial cells by a non-protease mechanism","volume":"39","author":"Roschmann","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"2025041017392149900_CIT0077","doi-asserted-by":"publisher","first-page":"e94558","DOI":"10.1371\/journal.pone.0094558","article-title":"Immunotherapy reduces allergen-mediated CD66b expression and myeloperoxidase levels on human neutrophils from allergic patients","volume":"9","author":"Aroca","year":"2014","journal-title":"PLoS One"},{"key":"2025041017392149900_CIT0078","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1177\/039463200802100419","article-title":"Breath markers of oxidative stress and airway inflammation in seasonal allergic rhinitis","volume":"21","author":"Gratziou","year":"2008","journal-title":"Int J Immunopathol Pharmacol"},{"key":"2025041017392149900_CIT0079","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1007\/s00405-015-3819-y","article-title":"Is neutrophil\u2013lymphocyte ratio associated with the severity of allergic rhinitis in children","volume":"273","author":"Dogru","year":"2016","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2025041017392149900_CIT0080","doi-asserted-by":"publisher","first-page":"602","DOI":"10.14744\/nci.2022.96236","article-title":"The association of allergic rhinitis severity with neutrophil-lymphocyte and platelet-lymphocyte ratio in children","volume":"9","author":"Cansever","year":"2022","journal-title":"North Clin Istanb"},{"key":"2025041017392149900_CIT0081","doi-asserted-by":"publisher","first-page":"94","DOI":"10.15586\/aei.v49i5.204","article-title":"Association of severity of allergic rhinitis with neutrophil-to-lymphocyte, eosinophil-to-neutrophil, and eosinophil-to-lymphocyte ratios in adults","volume":"49","author":"Kant","year":"2021","journal-title":"Allergol Immunopathol (Madr)"},{"key":"2025041017392149900_CIT0082","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S2213-2600(17)30293-X","article-title":"Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"5","author":"Collaborators GBDCRD","year":"2017","journal-title":"Lancet Respir Med"},{"key":"2025041017392149900_CIT0083","author":"Asthma GIf","year":"2023"},{"key":"2025041017392149900_CIT0084","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1136\/thorax.57.10.875","article-title":"Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids","volume":"57","author":"Green","year":"2002","journal-title":"Thorax"},{"key":"2025041017392149900_CIT0085","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1016\/j.jaci.2013.10.011","article-title":"Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis","volume":"133","author":"Moore","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0086","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1164\/ajrccm\/148.3.713","article-title":"Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa","volume":"148","author":"Sur","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"2025041017392149900_CIT0087","author":"Asthma GIf","year":"2020"},{"key":"2025041017392149900_CIT0088","doi-asserted-by":"publisher","first-page":"267","DOI":"10.4103\/lungindia.lungindia_502_18","article-title":"Inflammatory phenotypes of severe asthma in India","volume":"36","author":"Dasgupta","year":"2019","journal-title":"Lung India"},{"key":"2025041017392149900_CIT0089","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1155\/2011\/920734","article-title":"Association between proximity to major roads and sputum cell counts","volume":"18","author":"Wallace","year":"2011","journal-title":"Can Respir J"},{"key":"2025041017392149900_CIT0090","author":"Institute HE","year":"2022"},{"key":"2025041017392149900_CIT0091","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1111\/cea.12907","article-title":"Cigarette smoking increases bronchial mucosal IL-17A expression in asthmatics, which acts in concert with environmental aeroallergens to engender neutrophilic inflammation","volume":"47","author":"Siew","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"2025041017392149900_CIT0092","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"2025041017392149900_CIT0093","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.jaci.2018.02.004","article-title":"Obesity and asthma","volume":"141","author":"Peters","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0094","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1183\/09031936.00139810","article-title":"Airway inflammation is augmented by obesity and fatty acids in asthma","volume":"38","author":"Scott","year":"2011","journal-title":"Eur Respir J"},{"key":"2025041017392149900_CIT0095","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1136\/thoraxjnl-2020-215986","article-title":"Neutrophils in asthma: the good, the bad and the bacteria","volume":"76","author":"Crisford","year":"2021","journal-title":"Thorax"},{"key":"2025041017392149900_CIT0096","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/j.1365-2133.1994.tb08532.x","article-title":"The U.K. Working Party\u2019s Diagnostic Criteria for Atopic Dermatitis. III. Independent hospital validation","volume":"131","author":"Williams","year":"1994","journal-title":"Br J Dermatol"},{"key":"2025041017392149900_CIT0097","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.jaci.2009.10.009","article-title":"Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three","volume":"124","author":"Odhiambo","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0098","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/bjd.14997","article-title":"Filaggrin failure\u2014from ichthyosis vulgaris to atopic eczema and beyond","volume":"175","author":"McLean","year":"2016","journal-title":"Br J Dermatol"},{"key":"2025041017392149900_CIT0099","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.anai.2018.12.003","article-title":"The role of the skin microbiome in atopic dermatitis","volume":"122","author":"Nakatsuji","year":"2019","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2025041017392149900_CIT0100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1046\/j.1365-2133.2002.04872.x","article-title":"Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis","volume":"147","author":"Breuer","year":"2002","journal-title":"Br J Dermatol"},{"key":"2025041017392149900_CIT0101","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/jid.2008.259","article-title":"Atopic dermatitis: a disease caused by innate immune defects","volume":"129","author":"De Benedetto","year":"2009","journal-title":"J Invest Dermatol"},{"key":"2025041017392149900_CIT0102","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.aller.2009.06.003","article-title":"Evaluation of phagocytes in atopic dermatitis","volume":"37","author":"Forte","year":"2009","journal-title":"Allergol Immunopathol (Madr)"},{"key":"2025041017392149900_CIT0103","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/0091-6749(88)90140-6","article-title":"Atopic dermatitis: influence of bacterial infections on human monocyte and neutrophil granulocyte functional activities","volume":"82","author":"Mrowietz","year":"1988","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0104","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1001\/archderm.1976.01630340009002","article-title":"Immunodeficiencies in severe atopic dermatitis. Depressed chemotaxis and lymphocyte transformation","volume":"112","author":"Rogge","year":"1976","journal-title":"Arch Dermatol"},{"key":"2025041017392149900_CIT0105","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1159\/000339180","article-title":"Functional and phenotypical impairment of polymorphonuclear cells in atopic dermatitis: an additional cause for the known susceptibility to infections","volume":"224","author":"Fierro","year":"2012","journal-title":"Dermatology"},{"key":"2025041017392149900_CIT0106","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.jaci.2003.12.583","article-title":"The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype","volume":"113","author":"Ahmad-Nejad","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0107","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jaci.2006.04.033","article-title":"Innate immune defects in atopic dermatitis","volume":"118","author":"McGirt","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0108","doi-asserted-by":"publisher","first-page":"eaat1479","DOI":"10.1126\/scitranslmed.aat1479","article-title":"An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis","volume":"11","author":"Jonsson","year":"2019","journal-title":"Sci Transl Med"},{"key":"2025041017392149900_CIT0109","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.clindermatol.2020.06.012","article-title":"Neutrophilic drug reactions","volume":"38","author":"Coromilas","year":"2020","journal-title":"Clin Dermatol"},{"key":"2025041017392149900_CIT0110","doi-asserted-by":"publisher","first-page":"7880","DOI":"10.3390\/ijms24097880","article-title":"Drug-induced Enterocolitis syndrome in children","volume":"24","author":"Di Filippo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2025041017392149900_CIT0111","doi-asserted-by":"publisher","first-page":"5640","DOI":"10.1182\/blood-2012-01-380121","article-title":"Properties of mouse and human IgG receptors and their contribution to disease models","volume":"119","author":"Bruhns","year":"2012","journal-title":"Blood"},{"key":"2025041017392149900_CIT0112","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1111\/all.15308","article-title":"Platelet-activating factor acetylhydrolase is a biomarker of severe anaphylaxis in children","volume":"77","author":"Upton","year":"2022","journal-title":"Allergy"},{"key":"2025041017392149900_CIT0113","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1084\/jem.187.11.1779","article-title":"Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor","volume":"187","author":"Ishii","year":"1998","journal-title":"J Exp Med"},{"key":"2025041017392149900_CIT0114","doi-asserted-by":"publisher","first-page":"S141","DOI":"10.1016\/j.jaci.2008.12.526","article-title":"Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions","volume":"123","author":"Arias","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"2025041017392149900_CIT0115","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.3390\/jcm8091338","article-title":"Platelet-Activating Factor (PAF) in allergic rhinitis: clinical and therapeutic implications","volume":"8","author":"Munoz-Cano","year":"2019","journal-title":"J Clin Med"},{"key":"2025041017392149900_CIT0116","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s40521-014-0020-2","article-title":"Potential therapeutic strategies for severe anaphylaxis targeting platelet-activating factor and PAF acetylhydrolase","volume":"1","author":"Upton","year":"2014","journal-title":"Curr Treat Options Allergy"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cei\/advance-article-pdf\/doi\/10.1093\/cei\/uxae126\/61274260\/uxae126.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/219\/1\/uxae126\/61274260\/uxae126.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/219\/1\/uxae126\/61274260\/uxae126.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T17:39:32Z","timestamp":1744306772000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/doi\/10.1093\/cei\/uxae126\/7932528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":116,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,21]]}},"URL":"https:\/\/doi.org\/10.1093\/cei\/uxae126","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2024,12,26]]},"article-number":"uxae126"}}