{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:44:51Z","timestamp":1790023491001,"version":"4.0.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302050"],"award-info":[{"award-number":["82302050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404589"],"award-info":[{"award-number":["82404589"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M762748"],"award-info":[{"award-number":["2024M762748"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Top-level Talents Support Program of Yangzhou University","award":["137013502"],"award-info":[{"award-number":["137013502"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Wound healing causes heavy economic burdens for families and society, becoming a critical issue in the global healthcare system. While the role of immune cells in the wound-healing process is well-established, the involvement of B cells remains poorly understood. This study aims to elucidate the essentiality of B cells in wound repair. Our findings demonstrate a rise in B-cell population during the early stage of wound healing, which further intensifies during the later stage. We employed anti-CD20 antibodies to deplete B cells in mice and created a whole skin excisional wound mice model, analyzing wound closure over 12 days. B cells were isolated from the animals\u2019 spleen and co-cultured with macrophages from bone marrow. The polarization of M1 and M2 macrophages was analyzed by real-time qPCR and flow cytometry. The wound healing process in mice was observed to be considerably delayed following the elimination of B cells. The wounds exhibited a state of inflammation primarily characterized by the presence of pro-inflammatory M1 macrophages. The decrease in M2 macrophages within the local wound area resulted in impairment of the wound repair mechanism. B-cell-macrophage co-culture system revealed that B cells effectively induce the polarization of macrophages towards M2-like phenotype. Furthermore, we found that follicular B cells play predominant role in modulating the polarization of M2 macrophages. Consequently, our findings indicate that B cells can be recruited to the wound site and facilitate the polarization of M2-like macrophages, thereby accelerating the healing process during wound healing.<\/jats:p>","DOI":"10.1093\/cei\/uxaf002","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T15:39:58Z","timestamp":1737128398000},"source":"Crossref","is-referenced-by-count":12,"title":["B cells recruitment promotes M2 macrophage polarization to inhibit inflammation during wound healing"],"prefix":"10.1093","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8924-5650","authenticated-orcid":false,"given":"Yuye","family":"Yin","sequence":"first","affiliation":[{"name":"College of Bioscience and Biotechnology, Yangzhou University , Yangzhou, Jiangsu,","place":["China"]},{"name":"Affiliated Hospital of Jiangnan University , Wuxi, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Yangzhou University, Yangzhou University , Yangzhou, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"2025041017385453600_CIT0001","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s41038-016-0027-y","article-title":"Skin tissue engineering advances in severe burns: review and therapeutic applications","volume":"4","author":"Chua","year":"2016","journal-title":"Burns Trauma"},{"key":"2025041017385453600_CIT0002","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.jsr.2012.08.015","article-title":"The national center for injury prevention and control on its 20th Anniversary: a safe future and the importance of 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