{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:48:43Z","timestamp":1794019723046,"version":"4.8.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100019473","name":"Ministry of Science & Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019473","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Government of India","award":["SR\/SO\/SH-0159\/2010"],"award-info":[{"award-number":["SR\/SO\/SH-0159\/2010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Despite their synovial enrichment, regulatory T cells (Treg) fail to alleviate the joint inflammation in rheumatoid arthritis (RA). This indicates their functional impairment in the synovial milieu of RA patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Here, we demonstrate that a deficit in the PD-1 pathway incapacitates the synovial Treg cells, and engaging programmed cell death protein-1 (PD-1) restores their suppressive function (interleukin 10, transforming growth factor beta secretion), which in turn suppresses the synovial inflammatory T cells (IFN-\u03b3+, IL-17+\u2005TNF-\u03b1+). We also showed that a deficit in programmed death ligand-1 expression on RA synovial macrophages contributes to impaired Treg cell function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Rejuvenating synovial Treg cell function via PD-1 engagement may be a potential strategy to ameliorate the synovial inflammation in RA patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cei\/uxaf035","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T12:25:29Z","timestamp":1748435129000},"source":"Crossref","is-referenced-by-count":3,"title":["Engaging PD-1 rescuesregulatory T cell function and inhibits inflammatory T cells in rheumatoid arthritis"],"prefix":"10.1093","volume":"219","author":[{"given":"Kaustav","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Department of Transplant Immunology & Immunogenetics, AIIMS , New Delhi ,","place":["India"]},{"name":"Department of Rheumatology, AIIMS , New Delhi ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, AIIMS , New Delhi ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaydeep","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Indian Institute of Chemical Biology, CSIR , Kolkata ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Transplant Immunology & Immunogenetics, AIIMS , New Delhi ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumabha","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, AIIMS , New Delhi ,","place":["India"]},{"name":"Comanche County Memorial Hospital , 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