{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:24:51Z","timestamp":1792448691551,"version":"4.5.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":342,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020643","name":"MRC","doi-asserted-by":"publisher","award":["MR\/M009114\/1"],"award-info":[{"award-number":["MR\/M009114\/1"]}],"id":[{"id":"10.13039\/501100020643","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neutrophils contribute to systemic lupus erythematosus (SLE) pathogenesis through reactive oxygen species and neutrophil extracellular trap (NET) production, and increased apoptotic debris which causes autoantibody production and immune complex formation. These processes drive inflammation and tissue damage. The aim of this study was to perform integrated transcriptomic and metabolomic analyses comparing paediatric and adult SLE neutrophils. Adult (aSLE) and paediatric (jSLE) patient and healthy adult (HA) and juvenile (HJ) control neutrophils were subjected to RNAseq and 1H-NMR metabolomics. Univariate, multivariate and multiomics enrichment analyses were conducted in R and with ingenuity pathway analysis (IPA). Transcriptomic analysis revealed distinct gene expression profiles. Adult and juvenile SLE neutrophils were enriched for genes regulating interferon (IFN)-\u03b1\/\u03b2 signalling, neutrophil degranulation and NET signalling pathways (IPA, adj.P-value &amp;lt;0.01). Gene Ontology analysis revealed enrichment in cell cycle and interferon signalling in aSLE and angiogenesis and tissue-specific development in jSLE. Metabolomic profiling identified distinct metabolic alterations in aSLE, with a greater complexity of metabolic changes in jSLE. Multivariate PLS-DA demonstrated group discrimination, particularly in aSLE (balanced accuracy 80%, sensitivity 80%). Variable importance in the projection &amp;gt;1 metabolites were enriched in taurine\/hypotaurine and amino acid metabolism in aSLE. Integrating transcriptomic and metabolomic data strengthened IFN-\u03b1\/\u03b2 signalling, neutrophil degranulation and NET signalling (adj. P &amp;lt; 0.001). Additional metabolic pathways uniquely down-regulated in aSLE included glutamate and glutamine metabolism, nucleotide biosynthesis and tryptophan catabolism (adj.P&amp;lt; 0.01). In summary, neutrophils from SLE patients, especially in jSLE, displayed complex transcriptomic and metabolic profiles, with aberrant IFN responses and neutrophil activation.<\/jats:p>","DOI":"10.1093\/cei\/uxaf077","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T12:58:00Z","timestamp":1765025880000},"source":"Crossref","is-referenced-by-count":5,"title":["Multiomics analysis of neutrophils in SLE: insights from adult and paediatric disease"],"prefix":"10.1093","volume":"219","author":[{"given":"Grace","family":"Filbertine","sequence":"first","affiliation":[{"name":"Institute of Life Course and Medical Sciences, University of Liverpool , Liverpool ,","place":["UK"]},{"name":"Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology, Faculty of Medicine, Chulalongkorn University , Bangkok 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,","place":["UK"]},{"name":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Liverpool ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie M","family":"Phelan","sequence":"additional","affiliation":[{"name":"High-Field NMR Facility, Liverpool Shared Research Facilities (LivSRF), University of Liverpool , Liverpool ,","place":["UK"]},{"name":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Liverpool ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"McLaren","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Liverpool University Hospitals NHS Foundation Trust , Liverpool ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawatchai","family":"Deekajorndech","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, Faculty of Medicine, 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