{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:25:23Z","timestamp":1790774723311,"version":"4.1.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Science Foundation of China","doi-asserted-by":"publisher","award":["81471542"],"award-info":[{"award-number":["81471542"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation\u2014General Program","award":["2024-MSLH-595"],"award-info":[{"award-number":["2024-MSLH-595"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a systemic autoimmune disease characterized by significant renal involvement, yet identifying novel biomarkers for renal complications remains a clinical priority. Metrnl is a recently identified immunomodulatory cytokine implicated in inflammation, but its specific role in AAV has historically been unknown. To address this, this study investigated serum Metrnl levels via ELISA in 37 patients with microscopic polyangiitis (MPA), 17 with granulomatosis with polyangiitis (GPA), and 30 healthy controls (HCs), analysing correlations with clinical parameters such as the Birmingham Vasculitis Activity Score (BVAS) and renal function indicators under false discovery rate (FDR) correction. The results demonstrated that serum Metrnl levels were significantly elevated in both MPA and GPA patients compared to HCs and exhibited a strong positive correlation with BVAS in both subgroups. Crucially, following FDR adjustment, Metrnl levels showed significant correlations with key markers of renal impairment, including creatinine, cystatin C, and estimated glomerular filtration rate (eGFR). Stratification of MPA patients based on renal function (eGFR cut-off: 60\u2005ml\/min\/1.73\u2005m\u00b2) further revealed substantially higher Metrnl levels in those with impaired renal function. Receiver operating characteristic curve analysis indicated superior diagnostic efficacy for Metrnl in identifying AAV with renal involvement [area under the curve (AUC) = 0.8150] compared to diagnosing AAV overall (AUC = 0.7214). Collectively, these findings provide the first evidence that serum Metrnl is elevated in AAV and associated with disease activity and renal dysfunction, suggesting that Metrnl warrants further investigation as a potential biomarker for renal involvement in AAV.<\/jats:p>","DOI":"10.1093\/cei\/uxaf087","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T12:52:48Z","timestamp":1766235168000},"source":"Crossref","is-referenced-by-count":3,"title":["Serum Metrnl as a potential biomarker for renal involvement in ANCA-associated vasculitis"],"prefix":"10.1093","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0164-5968","authenticated-orcid":false,"given":"Yuxin","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, The First Affiliated Hospital of China Medical University , Shenyang ,","place":["China"]},{"name":"Department of Rheumatology and Immunology, Xiongan Xuanwu Hospital , Xiongan New Area ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, The Fourth Affiliated Hospital of China Medical University , Shenyang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The First Affiliated Hospital of China Medical University , Shenyang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The First Affiliated Hospital of China Medical University , Shenyang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The First Affiliated Hospital of China Medical University , Shenyang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University , Shenyang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3501-1749","authenticated-orcid":false,"given":"Jing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The First Affiliated Hospital of China Medical University , Shenyang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"2026041706071664400_uxaf087-B1","doi-asserted-by":"crossref","first-page":"m1070","DOI":"10.1136\/bmj.m1070","article-title":"ANCA associated vasculitis","volume":"369","author":"Hunter","year":"2020","journal-title":"BMJ"},{"key":"2026041706071664400_uxaf087-B2","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/nrrheum.2016.123","article-title":"ANCA-associated vasculitis\u2014clinical utility of using ANCA specificity to classify patients","volume":"12","author":"Cornec","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"2026041706071664400_uxaf087-B3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.clim.2014.11.006","article-title":"METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages","volume":"156","author":"Ushach","year":"2015","journal-title":"Clin Immunol"},{"key":"2026041706071664400_uxaf087-B4","doi-asserted-by":"crossref","first-page":"1098570","DOI":"10.3389\/fimmu.2023.1098570","article-title":"Meteorin-like\/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: a comprehensive review of preclinical and clinical studies","volume":"14","author":"Li","year":"2023","journal-title":"Front Immunol"},{"key":"2026041706071664400_uxaf087-B5","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1038\/s41401-020-00529-9","article-title":"Involvement of the secreted protein metrnl in human diseases","volume":"41","author":"Miao","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"2026041706071664400_uxaf087-B6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cca.2022.11.021","article-title":"Increased serum IL-41 is associated with disease activity in rheumatoid arthritis","volume":"538","author":"Gong","year":"2023","journal-title":"Clin Chim Acta"},{"key":"2026041706071664400_uxaf087-B7","doi-asserted-by":"crossref","first-page":"156026","DOI":"10.1016\/j.cyto.2022.156026","article-title":"Elevated levels of metrnl in rheumatoid arthritis: association with disease activity","volume":"159","author":"Zhang","year":"2022","journal-title":"Cytokine"},{"key":"2026041706071664400_uxaf087-B8","first-page":"671","article-title":"Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis","volume":"87","author":"Luqmani","year":"1994","journal-title":"Qjm"},{"key":"2026041706071664400_uxaf087-B9","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/ecco-jcc\/jjz001","article-title":"The adipokine metrnl ameliorates chronic colitis in il-10-\/- mice by attenuating mesenteric adipose tissue lesions during spontaneous colitis","volume":"13","author":"Zuo","year":"2019","journal-title":"J Crohns Colitis"},{"key":"2026041706071664400_uxaf087-B10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00281-022-00920-0","article-title":"Mechanisms of vascular damage in ANCA vasculitis","volume":"44","author":"Massicotte-Azarniouch","year":"2022","journal-title":"Semin Immunopathol"},{"key":"2026041706071664400_uxaf087-B11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrneph.2017.37","article-title":"Complement in ANCA-associated vasculitis: mechanisms and implications for management","volume":"13","author":"Chen","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"2026041706071664400_uxaf087-B12","doi-asserted-by":"crossref","first-page":"1122972","DOI":"10.3389\/fimmu.2023.1122972","article-title":"Biomarkers of fibrosis, kidney tissue injury and inflammation may predict severity and outcome of renal ANCA\u2014associated vasculitis","volume":"14","author":"Satrapova","year":"2023","journal-title":"Front Immunol"},{"key":"2026041706071664400_uxaf087-B13","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/ckj\/sfac257","article-title":"Combining neutrophil and macrophage biomarkers to detect active disease in ANCA vasculitis: a combinatory model of calprotectin and urine 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