{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:02:07Z","timestamp":1776423727951,"version":"3.51.2"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100018985","name":"Walloon Region","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018985","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"Fond europ\u00e9en de d\u00e9veloppement r\u00e9gional","doi-asserted-by":"publisher","award":["246099-510388"],"award-info":[{"award-number":["246099-510388"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Li\u00e8ge University Hospital"},{"DOI":"10.13039\/501100002661","name":"F.R.S.-FNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite its interest for the development of personalized medicine, the immunological differences between ileal and colonic Crohn\u2019s disease (CD) have been understudied. For unknown reasons, some circulating antibodies are associated with CD location (ileal CD: anti-Saccharomyces cerevisiae antibodies, anti-flagellins antibodies, anti-granulocyte macrophage-colony stimulating factor autoantibodies, and some pancreatic autoantibodies; colonic CD: perinuclear antineutrophil cytoplasmic autoantibodies). Based on these observations, we hypothesized that, in tissues, the humoral response differs between ileal and colonic CD. This hypothesis was tested by analysing the expression of IgA1, IgA2, IgG1, IgG2, IgG3, IgM, and immunoglobulin J chain (IGJ) in our previous dataset comparing the proteome of ulcer edges and adjacent normal mucosa (paired design) in the ileum (4 428 proteins screened in 16 biopsies) and colon (5 204 proteins screened in 16 biopsies) of 16 patients with CD. All these proteins were increased in ileal ulcer edges compared with adjacent normal mucosa, whereas only IgG3 was increased in colonic ulcer edges compared with adjacent normal mucosa. These data highlight the distinct role of humoral immunity in ileal and colonic CD, thereby opening a new avenue of research for developing therapies tailored to CD location.<\/jats:p>","DOI":"10.1093\/cei\/uxag005","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T12:29:58Z","timestamp":1770640198000},"source":"Crossref","is-referenced-by-count":0,"title":["Higher humoral response in ileal versus colonic Crohn\u2019s disease"],"prefix":"10.1093","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1859-7146","authenticated-orcid":false,"given":"Sophie","family":"Vieujean","sequence":"first","affiliation":[{"name":"Laboratory of Translational Gastroenterology, GIGA-institute, University of Li\u00e8ge , Li\u00e8ge ,","place":["Belgium"]},{"name":"Hepato-Gastroenterology and Digestive Oncology Department, Li\u00e8ge University Hospital , Li\u00e8ge ,","place":["Belgium"]},{"name":"Department of Gastroenterology, INFINY Institute, INSERM NGERE, CHRU Nancy , Vand\u0153uvre-l\u00e8s-Nancy F-54500 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Immunology, GIGA-institute, University of Li\u00e8ge , Li\u00e8ge ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Fern\u00e1ndez-Verdejo","sequence":"additional","affiliation":[{"name":"Departmento de Nutrici\u00f3n y Diet\u00e9tica, Escuela de Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Cat\u00f3lica de Chile , Santiago ,","place":["Chile"]},{"name":"Pennington Biomedical Research Center, Louisiana State University , Baton Rouge, LA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Fraussen","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infection, Biomedical Research Institute, UHasselt\u2014Hasselt University , Hasselt ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1622-0118","authenticated-orcid":false,"given":"Dominique","family":"Baiwir","sequence":"additional","affiliation":[{"name":"GIGA Proteomics Facility, University of Li\u00e8ge , Li\u00e8ge ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Mazzucchelli","sequence":"additional","affiliation":[{"name":"Laboratory of Mass Spectrometry, MolSys Research Unit, University of Li\u00e8ge , Li\u00e8ge ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5490-4350","authenticated-orcid":false,"given":"Catherine","family":"Reenaers","sequence":"additional","affiliation":[{"name":"Hepato-Gastroenterology and Digestive Oncology Department, Li\u00e8ge University Hospital , Li\u00e8ge ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Van Kemseke","sequence":"additional","affiliation":[{"name":"Hepato-Gastroenterology and Digestive Oncology Department, Li\u00e8ge University Hospital , Li\u00e8ge ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Louis","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Gastroenterology, GIGA-institute, University of Li\u00e8ge , Li\u00e8ge ,","place":["Belgium"]},{"name":"Hepato-Gastroenterology and Digestive Oncology Department, Li\u00e8ge University Hospital , Li\u00e8ge ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8324-0434","authenticated-orcid":false,"given":"Nicolas","family":"Pierre","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Gastroenterology, GIGA-institute, University of Li\u00e8ge , 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