{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:02:03Z","timestamp":1776423723811,"version":"3.51.2"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802129"],"award-info":[{"award-number":["81802129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017592","name":"Science and Technology Planning Project of Shaanxi Province of China","doi-asserted-by":"publisher","award":["2023-YBSF-384"],"award-info":[{"award-number":["2023-YBSF-384"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017592","name":"Science and Technology Planning Project of Shaanxi Province of China","doi-asserted-by":"publisher","award":["2025SF-YBXM-378"],"award-info":[{"award-number":["2025SF-YBXM-378"]}],"id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic and Clinical Integration Innovation Project of Xi\u2019an Jiaotong University","award":["YXJLRH2022065"],"award-info":[{"award-number":["YXJLRH2022065"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Increased glycolytic metabolism in synovial fibroblasts contributes to their activated phenotype in rheumatoid arthritis (RA). Our previous results revealed that the activation of the dopamine D3 receptor (D3R) in mast cells reduced inflammation in a mouse model of RA. In this study, we explored the role of D3R in regulating dopamine-induced activation and glycolysis in synovial fibroblasts from patients with RA (RASFs). RASFs were cultured in the presence of dopamine. Pharmacological modulation of D3R-by-D3R agonist (7-OHDPAT) and antagonist (NGB2904) was used to investigate the regulatory role of D3R in dopamine-induced activation and glycolysis in RASFs. Dopamine stimulation induced a dose-dependent increase in cell viability and \u03b1-SMA expression in RASFs. Dopamine also caused significant and dose-dependent upregulation of glycolysis-related enzymes in RASFs. Treatment with 7-OH-DPAT inhibited dopamine-induced increases in \u03b1-SMA expression and inflammatory response in RASFs, whereas NGB2904 treatment resulted in the enhanced effects stimulated by dopamine. NGB2904 treatment upregulated glycolysis and the expression of glycolytic enzymes induced by dopamine, whereas 7-OH-DPAT treatment downregulated glycolysis and glycolytic enzymes in RASFs. NGB2904 attenuated the ability of 7-OH-DPAT to inhibit the dopamine-induced elevation in cAMP levels of RASFs. Involvements of the cAMP pathway was confirmed by findings that H89 (a PKA inhibitor) abrogated the upregulation of activation, glycolysis, and expression of glycolytic enzymes mediated by the D3R antagonist, NGB2904, in RASFs. D3R downregulates dopamine-induced activation and glycolysis of RASFs by suppressing PKA activity. Therefore, inhibition of glycolysis by manipulating the D3R pathway may provide a novel therapeutic strategy to reduce the activation of RASFs.<\/jats:p>","DOI":"10.1093\/cei\/uxag008","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T12:42:03Z","timestamp":1770381723000},"source":"Crossref","is-referenced-by-count":0,"title":["The dopamine D3 receptor regulates dopamine-induced activation and glycolytic metabolism of synovial fibroblasts in rheumatoid arthritis"],"prefix":"10.1093","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-6609","authenticated-orcid":false,"given":"Li","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi\u2019an ,","place":["China"]},{"name":"Centre for Rheumatology and Connective Tissue Diseases, Division of Medicine, University College London , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiwen","family":"Xu","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology and Connective Tissue Diseases, Division of Medicine, University College London , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First Affiliated Hospital of Xi'an Jiaotong University , Xi\u2019an ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogenic Biology, College of Basic Medicine, Xi\u2019an Jiaotong University Health Science Center , Xi\u2019an ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Kang","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology and Connective Tissue Diseases, Division of Medicine, University College London , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi\u2019an ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix I L","family":"Clanchy","sequence":"additional","affiliation":[{"name":"Kennedy Institute of Rheumatology, University of Oxford , Oxford ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard O","family":"Williams","sequence":"additional","affiliation":[{"name":"Kennedy Institute of Rheumatology, University of Oxford , Oxford ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Abraham","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology and Connective Tissue Diseases, Division of Medicine, University College London , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi\u2019an ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"2026041706072704200_uxag008-B1","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: a review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA"},{"key":"2026041706072704200_uxag008-B2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF02231526","article-title":"Rheumatoid arthritis as a cause of cardiac compression. 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