{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:01:26Z","timestamp":1776423686135,"version":"3.51.2"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":83,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministry of Health of the Czech Republic","doi-asserted-by":"publisher","award":["#NU20-05-00146"],"award-info":[{"award-number":["#NU20-05-00146"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Role of the anti-inflammatory cytokine IL-10 in allergic eosinophilic asthma (AEA) remains controversial, with studies reporting inconsistent findings. Nevertheless, reduced IL-10 production has been described and may contribute to the pathophysiologic features of the disease. Here, we compared FoxP3+IL-10+ Treg cells with the complosome-CD46-induced regulatory FoxP3\u2212IL-10+ T cell capacity to produce IL-10 in AEA. We analyzed CD4+ T cells from 58 adults with controlled AEA and 49 healthy donors using ex vivo phenotypic characterization combined with a defined \u03b1CD3\/\u03b1CD46\/IL-2 activation model. CD4+ T cells from patients with controlled AEA showed a predominance of memory CD4+ T cells, reduced frequencies of FoxP3+ Treg cells and increased IFN-\u03b3 plasma levels. After CD46-mediated activation in vitro, CD4+FoxP3\u2212 T cells from AEA patients exhibited enhanced IFN-\u03b3 production together with altered expression of complosome-associated components, including increased CD46 expression and reduced surface C3bIn parallel, reduced frequencies of CD4+FoxP3+ Treg cells with impaired IL-10-producing capacity and normal levels of regulatory FoxP3\u2212IL10+CD49b+ T cells were observed in AEA. The inducible regulatory response within the FoxP3\u2212 compartment was primarily driven by increased IL-10 secretion at the single-cell level rather than by an increased frequency of IL-10+ cells. Together, these findings define ex vivo features of complosome-associated CD4+ T cell activation in controlled AEA and indicate that impaired FoxP3+ T cells with diminished IL-10-producing capacity can be partially compensated by complosome-CD46 driven differentiation of CD4+FoxP3\u2212 T cells with stronger IL-10 secretion despite overall increase in T1 responses under defined experimental conditions.<\/jats:p>","DOI":"10.1093\/cei\/uxag017","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:21:18Z","timestamp":1774268478000},"source":"Crossref","is-referenced-by-count":0,"title":["Reduced IL-10 production by FoxP3+IL-10+ Treg cells is partially compensated by complosome-associated induction of regulatory FoxP3\u2212IL-10+ T cells in allergic eosinophilic asthma"],"prefix":"10.1093","volume":"220","author":[{"given":"Julie","family":"Stichova","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Immunology and Allergology, Masaryk University , Brno ,","place":["Czechia"]},{"name":"Institute of Clinical Immunology and Allergology, St. Anne\u2019s University Hospital , Brno ,","place":["Czechia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Slanina","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Immunology and Allergology, Masaryk University , Brno ,","place":["Czechia"]},{"name":"Institute of Clinical Immunology and Allergology, St. Anne\u2019s University Hospital , Brno ,","place":["Czechia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zita","family":"Chovancova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Immunology and Allergology, Masaryk University , Brno ,","place":["Czechia"]},{"name":"Institute of Clinical Immunology and Allergology, St. Anne\u2019s University Hospital , Brno ,","place":["Czechia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Baros","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Immunology and Allergology, Masaryk University , Brno ,","place":["Czechia"]},{"name":"Institute of Clinical Immunology and Allergology, St. Anne\u2019s University Hospital , Brno ,","place":["Czechia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Litzman","sequence":"additional","affiliation":[{"name":"Department of Economics, Faculty of Business and Economics, Mendel University , Brno ,","place":["Czechia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Litzman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Immunology and Allergology, Masaryk University , Brno ,","place":["Czechia"]},{"name":"Institute of Clinical Immunology and Allergology, St. Anne\u2019s University Hospital , Brno ,","place":["Czechia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2122-7784","authenticated-orcid":false,"given":"Marcela","family":"Vlkova","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Immunology and Allergology, Masaryk University , Brno ,","place":["Czechia"]},{"name":"Institute of Clinical Immunology and Allergology, St. Anne\u2019s University Hospital , Brno ,","place":["Czechia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"2026041706065580300_uxag017-B1","doi-asserted-by":"crossref","first-page":"101333","DOI":"10.1016\/j.smim.2019.101333","article-title":"Immunologic mechanisms in asthma","volume":"46","author":"Boonpiyathad","year":"2019","journal-title":"Semin 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