{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:12:34Z","timestamp":1792131154422,"version":"4.4.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["5U01AI151788"],"award-info":[{"award-number":["5U01AI151788"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Currently, the role of dengue virus-specific T-cell responses in disease pathogenesis and protection is not well understood, including potential differences in individuals with obesity. We sought to investigate the functionality and phenotype of T cells in patients with acute dengue fever (DF) or dengue haemorrhagic fever (DHF). T-cell function was assessed in paired samples (first sample on \u22644 days and second 5\u20136 days since onset of illness) in patients with DF (n = 50) and DHF (n = 12), using 109 peptides representing CD8+ epitopes and 90 peptides targeting CD4+ T-cell epitopes. Phenotypic analysis was performed in patients with DF (n = 21) and DHF (n = 21), recruited between days 6 and 8 since onset of illness, using multicolor flow cytometry. The frequency of ex vivo IFN\u03b3 ELISpot responses to both the CD4+ and CD8+ peptide pools significantly increased from first (F) to second (S) time point in patients with DF (P &amp;lt; 0.0001) but not with DHF. The frequency of ex vivo IFN\u03b3 ELISpot responses to CD4+ (P = 0.001) and CD8+ peptide pools (P = 0.0002) also significantly increased from the F to S in lean patients but not in obese patients. Cutaneous lymphocyte-associated antigen (CLA) expression was significantly higher in the CD8+ T-cell subset in patients with DF and DHF compared to healthy controls, and these differences were most significant in CD8+ CD45RA\u2212 T cells. CD8+ CD45RA\u2212CLA+ T cells consisted of &amp;gt;50% of the T cells in 9\/21 patients with DHF, with 92.7% expressing CD38. CLA expression was highest in the CD8+ CD45RA\u2212 T cells in obese individuals, which was significantly higher compared to lean individuals (P = 0.01). CD27 and CD127 were both significantly downregulated in patients with DHF compared to DF, with ICOS expression being significantly higher in CD8+ T cells in DHF. Patients with DHF and obese individuals had impaired T-cell functionality compared to patients with DF and lean individuals, with an expansion of activated, skin-homing CD8+ T cells exhibiting downregulation of CD27 and CD127. Our data suggest a contributory role of dysfunctional skin-homing T cells in disease pathogenesis, meriting further investigation.<\/jats:p>","DOI":"10.1093\/cei\/uxag049","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T11:26:22Z","timestamp":1786879582000},"source":"Crossref","is-referenced-by-count":1,"title":["Severity-associated changes in ICOS, CD27, CD127, and CLA expression and expansion of virus-specific T cells in acute dengue"],"prefix":"10.1093","volume":"220","author":[{"given":"Heshan","family":"Kuruppu","sequence":"first","affiliation":[{"name":"Institute of Allergology and Immunology, University of Sri Jayewardenepura , Gangodawila, Nugegoda ,","place":["Sri Lanka"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malithi","family":"De Silva","sequence":"additional","affiliation":[{"name":"Institute of Allergology and Immunology, University of Sri Jayewardenepura , Gangodawila, Nugegoda ,","place":["Sri Lanka"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chathumini","family":"Dissanayake","sequence":"additional","affiliation":[{"name":"Institute of Allergology and Immunology, University of Sri Jayewardenepura , Gangodawila, Nugegoda ,","place":["Sri Lanka"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radanee","family":"Rathnapriya","sequence":"additional","affiliation":[{"name":"Institute of Allergology and Immunology, University of Sri Jayewardenepura , Gangodawila, Nugegoda ,","place":["Sri Lanka"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananda","family":"Wijewickrama","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases , Angoda ,","place":["Sri Lanka"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damayanthi","family":"Idampitiya","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases , Angoda ,","place":["Sri Lanka"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-1350","authenticated-orcid":false,"given":"Lakshmanane","family":"Premkumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina School of Medicine , Chapel Hill, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6830-5175","authenticated-orcid":false,"given":"Chandima","family":"Jeewandara","sequence":"additional","affiliation":[{"name":"Institute of Allergology and Immunology, University of Sri Jayewardenepura , Gangodawila, Nugegoda ,","place":["Sri Lanka"]},{"name":"Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura , Gangodawila, Nugegoda ,","place":["Sri Lanka"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-045X","authenticated-orcid":false,"given":"Graham","family":"Ogg","sequence":"additional","affiliation":[{"name":"MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford , Oxford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9201-0449","authenticated-orcid":false,"given":"Gathsaurie Neelika","family":"Malavige","sequence":"additional","affiliation":[{"name":"Institute of Allergology and Immunology, University of Sri Jayewardenepura , Gangodawila, Nugegoda ,","place":["Sri Lanka"]},{"name":"Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura , Gangodawila, Nugegoda ,","place":["Sri Lanka"]},{"name":"MRC Translational Immune Discovery Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford , Oxford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"2026091112165132100_uxag049-B1","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1038\/s41467-025-58609-5","article-title":"The overlapping global distribution of dengue, chikungunya, Zika and yellow fever","volume":"16","author":"Lim","year":"2025","journal-title":"Nat Commun"},{"key":"2026091112165132100_uxag049-B2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0140-6736(24)01542-3","article-title":"Dengue: the threat to health now and in the future","volume":"404","author":"The","year":"2024","journal-title":"Lancet"},{"key":"2026091112165132100_uxag049-B3","doi-asserted-by":"crossref","first-page":"e0012932","DOI":"10.1371\/journal.pntd.0012932","article-title":"Assessing the global dengue burden: incidence, mortality, and disability trends over three decades","volume":"19","author":"Zhang","year":"2025","journal-title":"PLoS Negl Trop Dis"},{"key":"2026091112165132100_uxag049-B4","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/S1473-3099(20)30601-0","article-title":"Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis","volume":"21","author":"Sangkaew","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"2026091112165132100_uxag049-B5","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.molmed.2024.03.006","article-title":"Molecular mechanisms in the pathogenesis of dengue infections","volume":"30","author":"Malavige","year":"2024","journal-title":"Trends Mol Med"},{"key":"2026091112165132100_uxag049-B6","doi-asserted-by":"crossref","first-page":"e179771","DOI":"10.1172\/jci.insight.179771","article-title":"Frequency of dengue virus-specific T cells is related to infection outcome in endemic settings","volume":"10","author":"Galvez","year":"2025","journal-title":"JCI Insight"},{"key":"2026091112165132100_uxag049-B7","doi-asserted-by":"crossref","first-page":"e59067","DOI":"10.1371\/journal.pone.0059067","article-title":"Genetic variants of MICB and PLCE1 and associations with non-severe dengue","volume":"8","author":"Whitehorn","year":"2013","journal-title":"PLoS One"},{"key":"2026091112165132100_uxag049-B8","doi-asserted-by":"crossref","first-page":"eadh3067","DOI":"10.1126\/scitranslmed.adh3067","article-title":"Insights into dengue immunity from vaccine trials","volume":"15","author":"Ooi","year":"2023","journal-title":"Sci Transl Med"},{"key":"2026091112165132100_uxag049-B9","doi-asserted-by":"crossref","first-page":"e0006540","DOI":"10.1371\/journal.pntd.0006540","article-title":"Quantification of dengue virus specific T cell responses and correlation with viral load and clinical disease severity in acute dengue infection","volume":"12","author":"Wijeratne","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"2026091112165132100_uxag049-B10","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/iid3.271","article-title":"Association of dengue virus-specific polyfunctional T-cell responses with clinical disease severity in acute dengue infection","volume":"7","author":"Wijeratne","year":"2019","journal-title":"Immun Inflamm Dis"},{"key":"2026091112165132100_uxag049-B11","doi-asserted-by":"crossref","first-page":"E2046","DOI":"10.1073\/pnas.1305227110","article-title":"Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells","volume":"110","author":"Weiskopf","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026091112165132100_uxag049-B12","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/infdis\/jiw309","article-title":"HLA-DRB1 Alleles are associated with different magnitudes of dengue virus-specific CD4+ T-cell responses","volume":"214","author":"Weiskopf","year":"2016","journal-title":"J Infect Dis"},{"key":"2026091112165132100_uxag049-B13","doi-asserted-by":"crossref","first-page":"16922","DOI":"10.1073\/pnas.1010867107","article-title":"Immunodominant T-cell responses to dengue virus NS3 are associated with DHF","volume":"107","author":"Duangchinda","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026091112165132100_uxag049-B14","doi-asserted-by":"crossref","first-page":"115366","DOI":"10.1016\/j.celrep.2025.115366","article-title":"Distinct features of a peripheral T helper subset that drives the B cell response in dengue virus infection","volume":"44","author":"Ansari","year":"2025","journal-title":"Cell Rep"},{"key":"2026091112165132100_uxag049-B15","doi-asserted-by":"crossref","first-page":"100278","DOI":"10.1016\/j.xcrm.2021.100278","article-title":"Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection","volume":"2","author":"Rouers","year":"2021","journal-title":"Cell Rep Med"},{"key":"2026091112165132100_uxag049-B16","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S1473-3099(24)00100-2","article-title":"Efficacy and immunogenicity following dengue virus-1 human challenge after a tetravalent prime-boost dengue vaccine regimen: an open-label, phase 1 trial","volume":"24","author":"Lyke","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"2026091112165132100_uxag049-B17","doi-asserted-by":"crossref","first-page":"E1677","DOI":"10.1210\/jc.2012-1532","article-title":"Mast cells in human adipose tissue: link with morbid obesity, inflammatory status, and diabetes","volume":"97","author":"Divoux","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2026091112165132100_uxag049-B18","doi-asserted-by":"crossref","first-page":"638852","DOI":"10.3389\/fcimb.2021.638852","article-title":"The weight of obesity in immunity from influenza to COVID-19","volume":"11","author":"Andrade","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"2026091112165132100_uxag049-B19","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/s41591-023-02343-2","article-title":"Accelerated waning of the humoral response to COVID-19 vaccines in obesity","volume":"29","author":"van der Klaauw","year":"2023","journal-title":"Nat Med"},{"key":"2026091112165132100_uxag049-B20","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.4049\/jimmunol.0903220","article-title":"Diet-induced obesity impairs the T cell memory response to influenza virus infection","volume":"184","author":"Karlsson","year":"2010","journal-title":"J Immunol"},{"key":"2026091112165132100_uxag049-B21","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/ijo.2011.208","article-title":"Obesity is associated with impaired immune response to influenza vaccination in humans","volume":"36","author":"Sheridan","year":"2012","journal-title":"Int J Obes (Lond)"},{"key":"2026091112165132100_uxag049-B22","volume-title":"Comprehensive Guidelines for Prevention and Control of Dengue Fever and Dengue Haemorrhagic Fever","author":"WHO","year":"2011"},{"key":"2026091112165132100_uxag049-B23","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S2213-8587(21)00088-7","article-title":"Ethnicity-specific BMI cutoffs for obesity based on type 2 diabetes risk in England: a population-based cohort study","volume":"9","author":"Caleyachetty","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2026091112165132100_uxag049-B24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13098-022-00871-4","article-title":"Identifying metabolic syndrome in migrant Asian Indian adults with anthropometric and visceral fat action points","volume":"14","author":"Sluyter","year":"2022","journal-title":"Diabetol Metab Syndr"},{"key":"2026091112165132100_uxag049-B25","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/infdis\/jiae474","article-title":"Simultaneous co-circulation of two genotypes of dengue virus serotype 3 causing a large outbreak in Sri Lanka in year 2023","volume":"231","author":"Ariyaratne","year":"2024","journal-title":"J Infect Dis"},{"key":"2026091112165132100_uxag049-B26","doi-asserted-by":"crossref","first-page":"100951","DOI":"10.1016\/j.lanmic.2024.07.014","article-title":"Multiplex sample-sparing assay for detecting type-specific antibodies to Zika and dengue viruses: an assay development and validation study","volume":"6","author":"Hein","year":"2025","journal-title":"Lancet Microbe"},{"key":"2026091112165132100_uxag049-B27","doi-asserted-by":"publisher","author":"Bos","DOI":"10.1101\/2024.04.05.24305281"},{"key":"2026091112165132100_uxag049-B28","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/978-1-4939-8567-8_15","article-title":"Ex vivo ELISpot assay to investigate dengue virus specific T-cell responses","volume":"1808","author":"Malavige","year":"2018","journal-title":"Methods Mol Biol"},{"key":"2026091112165132100_uxag049-B29","doi-asserted-by":"crossref","first-page":"558","DOI":"10.4097\/kja.19087","article-title":"Multicollinearity and misleading statistical results","volume":"72","author":"Kim","year":"2019","journal-title":"Korean J Anesthesiol"},{"key":"2026091112165132100_uxag049-B30","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/cyto.a.20387","article-title":"Subject classification obtained by cluster analysis and principal component analysis applied to flow cytometric data","volume":"71","author":"Lugli","year":"2007","journal-title":"Cytometry A"},{"key":"2026091112165132100_uxag049-B31","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.1038\/s41467-025-60941-9","article-title":"Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight","volume":"16","author":"Gregorova","year":"2025","journal-title":"Nat Commun"},{"key":"2026091112165132100_uxag049-B32","doi-asserted-by":"crossref","first-page":"ofaf322","DOI":"10.1093\/ofid\/ofaf322","article-title":"Oxidative stress induced liver damage in dengue is exacerbated in those with obesity","volume":"12","author":"Kuruppu","year":"2025","journal-title":"Open Forum Infect Dis"},{"key":"2026091112165132100_uxag049-B33","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/eji.201041349","article-title":"Adiponectin is a negative regulator of antigen-activated T cells","volume":"41","author":"Wilk","year":"2011","journal-title":"Eur J Immunol"},{"key":"2026091112165132100_uxag049-B34","doi-asserted-by":"crossref","first-page":"115082","DOI":"10.1016\/j.intimp.2025.115082","article-title":"Role of leptin and adiponectin in immune response and inflammation","volume":"161","author":"Liu","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"2026091112165132100_uxag049-B35","doi-asserted-by":"crossref","first-page":"e0011613","DOI":"10.1371\/journal.pntd.0011613","article-title":"Adipokine levels and their association with clinical disease severity in patients with dengue","volume":"17","author":"Kuruppu","year":"2023","journal-title":"PLoS Negl Trop Dis"},{"key":"2026091112165132100_uxag049-B36","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3389\/fimmu.2013.00332","article-title":"Role of adipokines signaling in the modulation of T cells function","volume":"4","author":"Procaccini","year":"2013","journal-title":"Front Immunol"},{"key":"2026091112165132100_uxag049-B37","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3390\/vaccines10040612","article-title":"Transcriptomics of acute DENV-specific CD8+ T cells does not support qualitative differences as drivers of disease severity","volume":"10","author":"Grifoni","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"2026091112165132100_uxag049-B38","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.chom.2025.06.006","article-title":"Immune profiling in subclinical secondary dengue-infected cases reveals adaptive immune signatures correlated to protection from severe dengue","volume":"33","author":"Gonnella","year":"2025","journal-title":"Cell Host Microbe"},{"key":"2026091112165132100_uxag049-B39","doi-asserted-by":"crossref","first-page":"e92606","DOI":"10.7554\/eLife.92606","article-title":"Dengue viremia kinetics and effects on platelet count and clinical outcomes: an analysis of 2340 patients from Vietnam","volume":"13","author":"Vuong","year":"2024","journal-title":"Elife"},{"key":"2026091112165132100_uxag049-B40","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1038\/s41590-023-01654-3","article-title":"Global and cell type-specific immunological hallmarks of severe dengue progression identified via a systems immunology approach","volume":"24","author":"Ghita","year":"2023","journal-title":"Nat Immunol"},{"key":"2026091112165132100_uxag049-B41","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity","volume":"181","author":"Vaughn","year":"2000","journal-title":"J Infect Dis"},{"key":"2026091112165132100_uxag049-B42","doi-asserted-by":"crossref","first-page":"20497","DOI":"10.1038\/s41598-020-77565-2","article-title":"Conserved epitopes with high HLA-I population coverage are targets of CD8(+) T cells associated with high IFN-gamma responses against all dengue virus serotypes","volume":"10","author":"Adikari","year":"2020","journal-title":"Sci Rep"},{"key":"2026091112165132100_uxag049-B43","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.3389\/fimmu.2019.01359","article-title":"Longitudinal analysis of memory B and T cell responses to dengue virus in a 5-year prospective cohort study in Thailand","volume":"10","author":"Sanchez-Vargas","year":"2019","journal-title":"Front Immunol"},{"key":"2026091112165132100_uxag049-B44","doi-asserted-by":"crossref","first-page":"11259","DOI":"10.1128\/JVI.01424-16","article-title":"Characterization of human CD8 T cell responses in dengue virus-infected patients from India","volume":"90","author":"Chandele","year":"2016","journal-title":"J Virol"},{"key":"2026091112165132100_uxag049-B45","doi-asserted-by":"publisher","author":"Gunasinghe","DOI":"10.1101\/2025.04.13.25325724"},{"key":"2026091112165132100_uxag049-B46","doi-asserted-by":"crossref","first-page":"100913","DOI":"10.1016\/j.jpha.2023.12.003","article-title":"New advances of adiponectin in regulating obesity and related metabolic syndromes","volume":"14","author":"Han","year":"2024","journal-title":"J Pharm Anal"},{"key":"2026091112165132100_uxag049-B47","doi-asserted-by":"crossref","first-page":"eads5932","DOI":"10.1126\/scitranslmed.ads5932","article-title":"Distinct systemic immune responses in asymptomatic and symptomatic dengue virus infection","volume":"17","author":"Sungnak","year":"2025","journal-title":"Sci Transl Med"},{"key":"2026091112165132100_uxag049-B48","doi-asserted-by":"crossref","first-page":"278ra35","DOI":"10.1126\/scitranslmed.aaa0526","article-title":"Virus-specific T lymphocytes home to the skin during natural dengue infection","volume":"7","author":"Rivino","year":"2015","journal-title":"Sci Transl Med"},{"key":"2026091112165132100_uxag049-B49","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s42003-022-03682-5","article-title":"Dengue virus co-opts innate type 2 pathways to escape early control of viral replication","volume":"5","author":"Fonseka","year":"2022","journal-title":"Commun Biol"},{"key":"2026091112165132100_uxag049-B50","doi-asserted-by":"crossref","first-page":"104034","DOI":"10.1016\/j.isci.2022.104034","article-title":"Single-cell temporal analysis of natural dengue infection reveals skin-homing lymphocyte expansion one day before defervescence","volume":"25","author":"Arora","year":"2022","journal-title":"iScience"},{"key":"2026091112165132100_uxag049-B51","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.immuni.2021.11.017","article-title":"Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8(+) tissue-resident memory T cells","volume":"55","author":"Peng","year":"2022","journal-title":"Immunity"},{"key":"2026091112165132100_uxag049-B52","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12929-023-00916-4","article-title":"Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever","volume":"30","author":"Ioannidis","year":"2023","journal-title":"J Biomed Sci"},{"key":"2026091112165132100_uxag049-B53","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.coviro.2016.12.001","article-title":"The role of CD27 in anti-viral T-cell immunity","volume":"22","author":"Grant","year":"2017","journal-title":"Curr Opin Virol"},{"key":"2026091112165132100_uxag049-B54","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.tim.2008.08.011","article-title":"Loss of CD127 expression links immune activation and CD4(+) T cell loss in HIV infection","volume":"16","author":"Kiazyk","year":"2008","journal-title":"Trends Microbiol"},{"key":"2026091112165132100_uxag049-B55","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12865-022-00509-0","article-title":"Interleukin-7 regulates CD127 expression and promotes CD8(+) T cell activity in patients with primary cutaneous melanoma","volume":"23","author":"He","year":"2022","journal-title":"BMC Immunol"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cei\/advance-article-pdf\/doi\/10.1093\/cei\/uxag049\/70686953\/uxag049.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/220\/1\/uxag049\/70686953\/uxag049.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/220\/1\/uxag049\/70686953\/uxag049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:17:04Z","timestamp":1789143424000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/doi\/10.1093\/cei\/uxag049\/8764030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/cei\/uxag049","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"uxag049"}}