{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:54:57Z","timestamp":1791899697154,"version":"4.3.4"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent episodes of swelling, which can potentially be life-threatening, resulting in substantial physical, psychological, educational, and occupational burden. Treatment of HAE is divided into on-demand treatment for acute attacks and long-term prophylaxis for prevention of attacks, and there are now several effective therapies available. However, in the UK, use of on-demand therapy is intended for attacks defined as clinically significant, and access to long-term prophylaxis is determined primarily by frequency-based criteria. In this policy-focused review, we compare UK access criteria with international guidelines on best practice. We conclude that UK access criteria result in a group of HAE patients with persisting unmet need, and this may have a greater impact in children and young people. In view of this, we recommend greater flexibility in access criteria, allowing clinical judgement, shared decision-making, and broader measures of disease burden to inform treatment eligibility, so we can individualize care and fully meet the needs of these patients.<\/jats:p>","DOI":"10.1093\/cei\/uxag056","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:22:23Z","timestamp":1788780143000},"source":"Crossref","is-referenced-by-count":0,"title":["Management of hereditary angioedema in the UK: a comparison with international guidelines"],"prefix":"10.1093","volume":"220","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1736-2756","authenticated-orcid":false,"given":"Patrick F K","family":"Yong","sequence":"first","affiliation":[{"name":"Clinical Immunology and Allergy, Frimley Health NHS Foundation Trust , Frimley 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