{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:55:08Z","timestamp":1792842908359,"version":"4.5.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T00:00:00Z","timestamp":1586649600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C14\/17\/109"],"award-info":[{"award-number":["C14\/17\/109"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek-Vlaanderen","doi-asserted-by":"crossref","award":["G0D5817N"],"award-info":[{"award-number":["G0D5817N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek-Vlaanderen","doi-asserted-by":"crossref","award":["G0B8617N"],"award-info":[{"award-number":["G0B8617N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek-Vlaanderen","doi-asserted-by":"crossref","award":["G090714N"],"award-info":[{"award-number":["G090714N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek-Vlaanderen","doi-asserted-by":"crossref","award":["G088813N"],"award-info":[{"award-number":["G088813N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The ventral tegmental area (VTA) is a midbrain structure at the heart of the dopaminergic system underlying adaptive behavior. Endogenous firing rates of dopamine cells in the VTA vary from fast phasic bursts to slow tonic activity. Artificial perturbations of the VTA, through electrical or optogenetic stimulation methods, generate different and sometimes even contrasting behavioral outcomes depending on stimulation parameters such as frequency, amplitude, and pulse width. Here, we investigate the global functional effects of electrical stimulation frequency (10, 20, 50, and 100\u00a0Hz) of the VTA in rhesus monkeys. We stimulated 2 animals with chronic electrodes, either awake or anesthetized, while concurrently acquiring whole-brain functional magnetic resonance imaging (fMRI) signals. In the awake state, activity as a function of stimulation frequency followed an inverted U-shape in many cortical and subcortical structures, with highest activity observed at 20 and 50\u00a0Hz and lower activity at 10 and 100\u00a0Hz. Under anesthesia, the hemodynamic responses in connected brain areas were slightly positive at 10\u00a0Hz stimulation, but decreased linearly as a function of higher stimulation frequencies. A speculative explanation for the remarkable frequency dependence of stimulation-induced fMRI activity is that the VTA makes use of different frequency channels to communicate with different postsynaptic sites.<\/jats:p>","DOI":"10.1093\/cercor\/bhaa007","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T07:10:03Z","timestamp":1578467403000},"page":"4281-4296","source":"Crossref","is-referenced-by-count":34,"title":["Frequency- and State-Dependent Network Effects of Electrical Stimulation Targeting the Ventral Tegmental Area in Macaques"],"prefix":"10.1093","volume":"30","author":[{"given":"Sjoerd R","family":"Murris","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Laboratory of Neuro- and Psychophysiology, KU Leuven Medical School, Leuven 3000, Belgium"},{"name":"Leuven Brain Institute, KU Leuven, Leuven 3000, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Arsenault","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Laboratory of Neuro- and Psychophysiology, KU Leuven Medical School, Leuven 3000, Belgium"},{"name":"Leuven Brain Institute, KU Leuven, Leuven 3000, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Vanduffel","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Laboratory of Neuro- and Psychophysiology, KU Leuven Medical School, Leuven 3000, Belgium"},{"name":"Leuven Brain Institute, KU Leuven, Leuven 3000, Belgium"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA"},{"name":"Department of Radiology, Harvard Medical School, Boston, MA 02144, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,4,9]]},"reference":[{"key":"2020063011041802200_ref1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1017\/cjn.2019.16","article-title":"Effects of deep brain stimulation of the subthalamic nucleus settings on voice quality, intensity, and prosody in Parkinson\u2019s disease: preliminary evidence for speech optimization","volume":"46","author":"Abeyesekera","year":"2019","journal-title":"Can J Neurol Sci"},{"key":"2020063011041802200_ref2","doi-asserted-by":"crossref","first-page":"10829","DOI":"10.1523\/JNEUROSCI.2246-11.2011","article-title":"Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior","volume":"31","author":"Adamantidis","year":"2011","journal-title":"J Neurosci"},{"key":"2020063011041802200_ref3","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.cub.2014.04.044","article-title":"Role of the primate ventral tegmental area in reinforcement and motivation","volume":"24","author":"Arsenault","year":"2014","journal-title":"Curr Biol"},{"key":"2020063011041802200_ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-11527-9","article-title":"Ventral midbrain stimulation induces perceptual learning and cortical plasticity in primates","volume":"10","author":"Arsenault","year":"2019","journal-title":"Nat Commun"},{"key":"2020063011041802200_ref5","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1073\/pnas.1418031112","article-title":"Signature of consciousness in the dynamics of resting-state brain activity","volume":"112","author":"Barttfeld","year":"2015","journal-title":"Proc Natl Acad Sci"},{"key":"2020063011041802200_ref6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fnbeh.2013.00173","article-title":"Optogenetic stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self-administration","volume":"7","author":"Bass","year":"2013","journal-title":"Front Behav Neurosci"},{"key":"2020063011041802200_ref7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/mds.10145","article-title":"Mechanisms of deep brain stimulation","volume":"17","author":"Benabid","year":"2002","journal-title":"Mov Disord"},{"key":"2020063011041802200_ref8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/cne.902730109","article-title":"Regional and laminar distribution of the dopamine and serotonin innervation in the macaque cerebral cortex: a radioautographic study","volume":"273","author":"Berger","year":"1988","journal-title":"J Comp Neurol"},{"key":"2020063011041802200_ref9","doi-asserted-by":"crossref","first-page":"7821","DOI":"10.1523\/JNEUROSCI.15-12-07821.1995","article-title":"Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain","volume":"15","author":"Bergson","year":"1995","journal-title":"J Neurosci"},{"key":"2020063011041802200_ref10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuroimage.2018.04.059","article-title":"Contributions of dopaminergic and non-dopaminergic neurons to VTA-stimulation induced neurovascular responses in brain reward circuits","volume":"177","author":"Brocka","year":"2018","journal-title":"NeuroImage"},{"key":"2020063011041802200_ref11","first-page":"1","article-title":"A dendrite method foe cluster analysis","volume":"3","author":"Cali\u00f1ski","year":"1974","journal-title":"Commun Stat"},{"key":"2020063011041802200_ref12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nn.4191","article-title":"Brief optogenetic inhibition of dopamine neurons mimics endogenous negative reward prediction errors","volume":"19","author":"Chang","year":"2015","journal-title":"Nat Neurosci"},{"key":"2020063011041802200_ref13","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.neuroimage.2005.10.029","article-title":"Brain hemodynamic changes mediated by dopamine receptors: role of the cerebral microvasculature in dopamine-mediated neurovascular coupling","volume":"30","author":"Choi","year":"2006","journal-title":"NeuroImage"},{"key":"2020063011041802200_ref14","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/npp.2016.151","article-title":"Coordination of brain wide activity dynamics by dopaminergic neurons","volume":"42","author":"Decot","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"2020063011041802200_ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2012.06608.x","article-title":"Deep brain stimulation for movement and other neurologic disorders","volume":"1265","author":"Delong","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"2020063011041802200_ref16","doi-asserted-by":"crossref","first-page":"14273","DOI":"10.1523\/JNEUROSCI.1894-10.2010","article-title":"Influence of phasic and tonic dopamine release on receptor activation","volume":"30","author":"Dreyer","year":"2010","journal-title":"J Neurosci"},{"key":"2020063011041802200_ref17","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1126\/science.1153276","article-title":"Bottom-up dependent gating of frontal signals in early visual cortex","volume":"321","author":"Ekstrom","year":"2008","journal-title":"Science"},{"key":"2020063011041802200_ref18","doi-asserted-by":"crossref","first-page":"6985","DOI":"10.1073\/pnas.1603629113","article-title":"Cross-hemispheric dopamine projections have functional significance","volume":"113","author":"Fox","year":"2016","journal-title":"Proc Natl Acad Sci"},{"key":"2020063011041802200_ref19","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.neuroimage.2005.01.013","article-title":"Conjunction revisited","volume":"25","author":"Friston","year":"2005","journal-title":"NeuroImage"},{"key":"2020063011041802200_ref20","doi-asserted-by":"crossref","first-page":"10894","DOI":"10.1523\/JNEUROSCI.1839-17.2017","article-title":"Nonhuman primate optogenetics: recent advances and future directions","volume":"37","author":"Galvan","year":"2017","journal-title":"J Neurosci"},{"key":"2020063011041802200_ref21","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/cne.20668","article-title":"Afferents of the ventral tegmental area in the rat-anatomical substratum for integrative functions","volume":"490","author":"Geisler","year":"2005","journal-title":"J Comp Neurol"},{"key":"2020063011041802200_ref22","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/j.cub.2012.07.023","article-title":"Optogenetically induced behavioral and functional network changes in primates","volume":"22","author":"Gerits","year":"2012","journal-title":"Curr Biol"},{"key":"2020063011041802200_ref23","doi-asserted-by":"crossref","first-page":"10156","DOI":"10.1523\/JNEUROSCI.2914-13.2013","article-title":"Probabilistic and single-subject retinotopic maps reveal the topographic organization of face patches in the macaque cortex","volume":"34","author":"Janssens","year":"2014","journal-title":"J Neurosci"},{"key":"2020063011041802200_ref24","volume-title":"Theory of Probability","author":"Jeffreys","year":"1961"},{"key":"2020063011041802200_ref25","doi-asserted-by":"crossref","first-page":"12506","DOI":"10.1073\/pnas.1819827116","article-title":"Routing information flow by separate neural synchrony frequencies allows for \u201cfunctionally labeled lines\u201d in higher primate cortex","volume":"116","author":"Khamechian","year":"2019","journal-title":"Proc Natl Acad Sci"},{"key":"2020063011041802200_ref26","doi-asserted-by":"crossref","first-page":"10168","DOI":"10.1523\/JNEUROSCI.3288-13.2014","article-title":"The retinotopic organization of macaque occipitotemporal cortex anterior to V4 and caudoventral to the middle temporal (MT) cluster","volume":"34","author":"Kolster","year":"2014","journal-title":"J Neurosci"},{"key":"2020063011041802200_ref27","doi-asserted-by":"crossref","first-page":"7031","DOI":"10.1523\/JNEUROSCI.0518-09.2009","article-title":"Visual field map clusters in macaque extrastriate visual cortex","volume":"29","author":"Kolster","year":"2009","journal-title":"J Neurosci"},{"key":"2020063011041802200_ref28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuroimage.2013.08.026","article-title":"Functional MRI reveals frequency-dependent responses during deep brain stimulation at the subthalamic nucleus or internal globus pallidus","volume":"84","author":"Lai","year":"2014","journal-title":"NeuroImage"},{"key":"2020063011041802200_ref29","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/nimg.2002.1110","article-title":"Repeated fMRI using iron oxide contrast agent in awake, behaving macaques at 3 tesla","volume":"16","author":"Leite","year":"2002","journal-title":"NeuroImage"},{"key":"2020063011041802200_ref30","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1006\/nimg.2000.0728","article-title":"Detection power, estimation efficiency, and predictability in event-related fMRI","volume":"13","author":"Liu","year":"2001","journal-title":"NeuroImage"},{"key":"2020063011041802200_ref31","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/nn.2631","article-title":"The effects of electrical microstimulation on cortical signal propagation","volume":"13","author":"Logothetis","year":"2010","journal-title":"Nat Neurosci"},{"key":"2020063011041802200_ref32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.celrep.2019.03.012","article-title":"Dopamine modulation of prefrontal cortex activity is manifold and operates at multiple temporal and spatial scales","volume":"27","author":"Lohani","year":"2019","journal-title":"Cell Rep"},{"key":"2020063011041802200_ref33","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/mp.2016.102","article-title":"Unexpected global impact of VTA dopamine neuron activation as measured by opto-fMRI","volume":"22","author":"Lohani","year":"2017","journal-title":"Mol Psychiatry"},{"key":"2020063011041802200_ref34","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuroimage.2013.02.036","article-title":"A receptor-based model for dopamine-induced fMRI signal","volume":"75","author":"Mandeville","year":"2013","journal-title":"NeuroImage"},{"key":"2020063011041802200_ref35","doi-asserted-by":"crossref","first-page":"12954","DOI":"10.1523\/JNEUROSCI.2318-11.2011","article-title":"Default mode of brain function in monkeys","volume":"31","author":"Mantini","year":"2011","journal-title":"J Neurosci"},{"key":"2020063011041802200_ref36","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/cercor\/8.4.321","article-title":"Widespread origin of the primate mesofrontal dopamine system","volume":"8","author":"Mark Williams","year":"1998","journal-title":"Cereb Cortex"},{"key":"2020063011041802200_ref37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.pscychresns.2003.12.007","article-title":"Functional MRI mapping of brain activation during visually guided saccades and antisaccades: cortical and subcortical networks","volume":"131","author":"Matsuda","year":"2004","journal-title":"Psychiatry Res Neuroimaging"},{"key":"2020063011041802200_ref38","doi-asserted-by":"crossref","first-page":"8251","DOI":"10.1073\/pnas.1318331111","article-title":"Face-selective neurons maintain consistent visual responses across months","volume":"111","author":"McMahon","year":"2014","journal-title":"Proc Natl Acad Sci"},{"key":"2020063011041802200_ref39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuroimage.2018.01.014","article-title":"Functional connectivity under six anesthesia protocols and the awake condition in rat brain","volume":"172","author":"Paasonen","year":"2018","journal-title":"NeuroImage"},{"key":"2020063011041802200_ref40","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuroimage.2014.09.064","article-title":"Frequency-dependent functional neuromodulatory effects on the motor network by ventral lateral thalamic deep brain stimulation in swine","volume":"105","author":"Paek","year":"2015","journal-title":"NeuroImage"},{"key":"2020063011041802200_ref41","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/1522-2594(200012)44:6<925::AID-MRM14>3.0.CO;2-M","article-title":"Impact of signal-to-noise on functional MRI","volume":"44","author":"Parrish","year":"2000","journal-title":"Magn Reson Med"},{"key":"2020063011041802200_ref42","doi-asserted-by":"crossref","first-page":"e1002072","DOI":"10.1371\/journal.pbio.1002072","article-title":"Effective connectivity of depth-structure\u2013selective patches in the Lateral Bank of the Macaque Intraparietal Sulcus","volume":"13","author":"Premereur","year":"2015","journal-title":"PLoS Biol"},{"key":"2020063011041802200_ref43","first-page":"4463","article-title":"Three-dimensional digital template atlas of the macaque brain","volume":"27","author":"Reveley","year":"2017","journal-title":"Cereb Cortex"},{"key":"2020063011041802200_ref44","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1080\/00273171.2012.734737","article-title":"Default bayes factors for model selection in regression","volume":"47","author":"Rouder","year":"2012","journal-title":"Multivar Behav Res"},{"key":"2020063011041802200_ref45","first-page":"4360","volume-title":"Proceedings of the International Society for Magnetic Resonance in Medicine","author":"Sander","year":"2019"},{"key":"2020063011041802200_ref46","doi-asserted-by":"crossref","first-page":"e98692","DOI":"10.1371\/journal.pone.0098692","article-title":"Real-time dopamine measurement in awake monkeys","volume":"9","author":"Schluter","year":"2014","journal-title":"PLoS One"},{"key":"2020063011041802200_ref47","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.neuro.28.061604.135722","article-title":"Multiple dopamine functions at different time courses","volume":"30","author":"Schultz","year":"2007","journal-title":"Annu Rev Neurosci"},{"key":"2020063011041802200_ref48","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1523\/JNEUROSCI.13-03-00900.1993","article-title":"Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task","volume":"13","author":"Schultz","year":"1993","journal-title":"J Neurosci"},{"key":"2020063011041802200_ref49","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/ALN.0000000000000117","article-title":"Electrical stimulation of the ventral tegmental area induces reanimation from general anesthesia","volume":"121","author":"Solt","year":"2014","journal-title":"Anesthesiology"},{"key":"2020063011041802200_ref50","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.cell.2016.08.024","article-title":"Dopamine neuron-specific optogenetic stimulation in rhesus macaques","volume":"166","author":"Stauffer","year":"2016","journal-title":"Cell"},{"key":"2020063011041802200_ref51","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/nn.3413","article-title":"A causal link between prediction errors, dopamine neurons and learning","volume":"16","author":"Steinberg","year":"2013","journal-title":"Nat Neurosci"},{"key":"2020063011041802200_ref52","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/AIA.0000000000000081","article-title":"FMRI and anesthesia","volume":"54","author":"Tang","year":"2016","journal-title":"Int Anesthesiol Clin"},{"key":"2020063011041802200_ref53","doi-asserted-by":"crossref","first-page":"12826","DOI":"10.1073\/pnas.1614340113","article-title":"Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia","volume":"113","author":"Taylor","year":"2016","journal-title":"Proc Natl Acad Sci"},{"key":"2020063011041802200_ref54","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1126\/science.1168878","article-title":"Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning","volume":"324","author":"Tsai","year":"2009","journal-title":"Science"},{"key":"2020063011041802200_ref55","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.neuroimage.2009.07.052","article-title":"Event-related functional MRI of cortical activity evoked by microsaccades, small visually-guided saccades, and eyeblinks in human visual cortex","volume":"49","author":"Tse","year":"2010","journal-title":"NeuroImage"},{"key":"2020063011041802200_ref56","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1097\/ALN.0000000000002336","article-title":"Resting-state dynamics as a cortical signature of anesthesia in monkeys","volume":"129","author":"Uhrig","year":"2018","journal-title":"Anesthesiology"},{"key":"2020063011041802200_ref57","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0896-6273(01)00502-5","article-title":"Visual motion processing investigated using contrast agent-enhanced fMRI in awake behaving monkeys","volume":"32","author":"Vanduffel","year":"2001","journal-title":"Neuron"},{"key":"2020063011041802200_ref58","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuroimage.2014.10.039","article-title":"Optogenetic fMRI reveals distinct, frequency-dependent networks recruited by dorsal and intermediate hippocampus stimulations","volume":"107","author":"Weitz","year":"2015","journal-title":"NeuroImage"},{"key":"2020063011041802200_ref59","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/nimg.1995.1023","article-title":"Analysis of fMRI time-series revisited\u2014again","volume":"2","author":"Worsley","year":"1995","journal-title":"NeuroImage"},{"key":"2020063011041802200_ref60","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1073\/pnas.1805561116","article-title":"Submillimeter fMRI reveals a layout of dorsal visual cortex in macaques, remarkably similar to new world monkeys","volume":"116","author":"Zhu","year":"2019","journal-title":"Proc Natl Acad Sci"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/30\/8\/4281\/33447261\/bhaa007.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/30\/8\/4281\/33447261\/bhaa007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T11:08:54Z","timestamp":1593515334000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/30\/8\/4281\/5818047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,9]]},"references-count":60,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,4,9]]},"published-print":{"date-parts":[[2020,6,30]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhaa007","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,8]]},"published":{"date-parts":[[2020,4,9]]}}}