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Whether this circuit is associated with other proposed measures of accelerated development is unknown. In a sample of young adolescents, we examined the relations among ELS, frontoamygdala circuitry during viewing of emotional faces, cellular aging as measured by telomere shortening, and pubertal tempo. We found that greater cumulative severity of ELS was associated with stronger negative coupling between bilateral centromedial amygdala and the ventromedial prefrontal cortex, a pattern that may reflect more mature connectivity. More negative frontoamygdala coupling (for distinct amygdala subdivisions) was associated with slower telomere shortening and pubertal tempo over 2\u00a0years. These potentially protective associations of negative frontoamygdala connectivity were most pronounced in adolescents who had been exposed to higher ELS. Our findings provide support for the formulation that ELS accelerates maturation of frontoamygdala connectivity and provide novel evidence that this neural circuitry confers protection against accelerated biological aging, particularly for adolescents who have experienced higher ELS. Although negative frontoamygdala connectivity may be an adaptation to ELS, frontoamygdala connectivity, cellular aging, and pubertal tempo do not appear to be measures of the same developmental process.<\/jats:p>","DOI":"10.1093\/cercor\/bhaa057","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T15:11:50Z","timestamp":1581693110000},"page":"4269-4280","source":"Crossref","is-referenced-by-count":56,"title":["Early Life Stress, Frontoamygdala Connectivity, and Biological Aging in Adolescence: A Longitudinal Investigation"],"prefix":"10.1093","volume":"30","author":[{"given":"Jonas G","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany C","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94304, USA"},{"name":"Department of Psychology, Stanford University, Stanford, CA 94305, USA"},{"name":"Department of Psychiatry and Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L","family":"Humphreys","sequence":"first","affiliation":[{"name":"Department of Psychology and Human Development, Vanderbilt University, Nashville, TN 37203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy S","family":"King","sequence":"first","affiliation":[{"name":"Department of Psychology, Stanford University, Stanford, CA 94305, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara C","family":"Foland-Ross","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie 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