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Memories of spatial sensory experience are encoded by means of synaptic plasticity in the hippocampus. Hippocampal dependency on sensory information is highlighted by the fact that sudden and complete loss of a sensory modality results in an impairment of hippocampal function that persists for months. Effects are accompanied by extensive changes in the expression of neurotransmitter receptors in cortex and hippocampus, consistent with a substantial adaptive reorganization of cortical function. Whether gradual sensory loss affects hippocampal function is unclear. Progressive age-dependent hearing loss (presbycusis) is a risk factor for cognitive decline. Here, we scrutinized C57BL\/6 mice that experience hereditary and cumulative deafness starting in young adulthood. We observed that 2\u20134\u00a0months postnatally, increases in the cortical and hippocampal expression of GluN2A and GluN2B subunits of the N-methyl-D-aspartate receptor occurred compared to control mice that lack sensory deficits. Furthermore, GABA and metabotropic glutamate receptor expression were significantly altered. Hippocampal synaptic plasticity was profoundly impaired and mice exhibited significant deficits in spatial memory. These data show that during cortical adaptation to cumulative loss of hearing, plasticity-related neurotransmitter expression is extensively altered in the cortex and hippocampus. Furthermore, cumulative sensory loss compromises hippocampal function.<\/jats:p>","DOI":"10.1093\/cercor\/bhaa061","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T20:17:44Z","timestamp":1583180264000},"page":"4581-4596","source":"Crossref","is-referenced-by-count":52,"title":["Hippocampal Synaptic Plasticity, Spatial Memory, and Neurotransmitter Receptor Expression Are Profoundly Altered by Gradual Loss of Hearing Ability"],"prefix":"10.1093","volume":"30","author":[{"given":"Daniela","family":"Beckmann","sequence":"first","affiliation":[{"name":"Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum 44780, Germany"},{"name":"International Graduate School of Neuroscience, Ruhr University Bochum, Bochum 44780, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Feldmann","sequence":"first","affiliation":[{"name":"Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum 44780, Germany"},{"name":"International Graduate School of Neuroscience, Ruhr University Bochum, Bochum 44780, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Shchyglo","sequence":"first","affiliation":[{"name":"Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum 44780, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Manahan-Vaughan","sequence":"first","affiliation":[{"name":"Department of Neurophysiology, Medical Faculty, Ruhr University Bochum, Bochum 44780, Germany"},{"name":"International Graduate School of Neuroscience, Ruhr University Bochum, Bochum 44780, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"key":"2020063011041273700_ref1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/hipo.22158","article-title":"Spatial olfactory learning facilitates long-term depression in the hippocampus","volume":"23","author":"Andr\u00e9","year":"2014","journal-title":"Hippocampus"},{"issue":"6","key":"2020063011041273700_ref2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1159\/000381619","article-title":"Olfaction and aging: a mini-review","volume":"61","author":"Attems","year":"2015","journal-title":"Gerontology"},{"key":"2020063011041273700_ref3","first-page":"33","article-title":"Afferent input selects NMDA receptor subtype to determine the persistency of hippocampal LTP in freely behaving mice","volume":"8","author":"Ballesteros","year":"2016","journal-title":"Front Behav Neurosci"},{"key":"2020063011041273700_ref4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuropharm.2006.07.016","article-title":"The role of NMDAR subtypes and charge transfer during hippocampal LTP induction","volume":"52","author":"Berberich","year":"2007","journal-title":"Neuropharmacology"},{"key":"2020063011041273700_ref5","doi-asserted-by":"crossref","first-page":"6907","DOI":"10.1523\/JNEUROSCI.1905-05.2005","article-title":"Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation","volume":"25","author":"Berberich","year":"2005","journal-title":"J Neurosci"},{"key":"2020063011041273700_ref6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbr.2005.08.009","article-title":"Rat ultrasonic vocalization in aversively motivated situations and the role of individual differences in anxiety-related behavior","volume":"166","author":"Borta","year":"2005","journal-title":"Behav Brain Res"},{"issue":"2","key":"2020063011041273700_ref7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000368399","article-title":"The mouse as a model for age-related hearing loss-a mini-review","volume":"61","author":"Bowl","year":"2015","journal-title":"Gerontology"},{"key":"2020063011041273700_ref8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neurobiolaging.2017.10.004","article-title":"Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer\u2019s disease pathology in older adults","volume":"62","author":"Brenowitz","year":"2018","journal-title":"Neurobiol Aging"},{"key":"2020063011041273700_ref9","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1601-183X.2004.00072.x","article-title":"Behavioural profiles of inbred mouse strains used as transgenic backgrounds. 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