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Electroencephalography was recorded while participants performed a task specifically designed to engage working memory and inhibitory processes, and the associations among functional activity, structural integrity, and cognitive performance were assessed. We found that the association between white matter microstructural integrity and cognitive functioning with aging is mediated by time-varying alpha and gamma phase-locking value. Specifically, better preservation of the inferior fronto-occipital fasciculus in older individuals drives faster task-related modulations of alpha and gamma long-range phase-locking value between the inferior frontal gyrus and occipital lobe and lower local phase-amplitude coupling in occipital lobes, which in turn drives better cognitive control performance. Our results help delineate the role of individual variability of white matter microstructure in dynamic synchrony and cognitive performance during normal aging.<\/jats:p>","DOI":"10.1093\/cercor\/bhaa141","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T15:09:30Z","timestamp":1588864170000},"page":"5570-5582","source":"Crossref","is-referenced-by-count":35,"title":["Disrupted Neural Synchrony Mediates the Relationship between White Matter Integrity and Cognitive Performance in Older Adults"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9939-0640","authenticated-orcid":false,"given":"T","family":"Hinault","sequence":"first","affiliation":[{"name":"U1077 INSERM-EPHE-UNICAEN, Caen, 14000, France"},{"name":"Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, 21218, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kraut","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA"},{"name":"F.M. 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