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The medial OFC and ventromedial prefrontal cortex have direct connections with the pregenual and subgenual parts of the anterior cingulate cortex; all of which are reward-related areas. The lateral OFC (OFClat) and its closely connected right inferior frontal gyrus (rIFG) have direct connections with the supracallosal anterior cingulate cortex; all of which are punishment or nonreward-related areas. The OFClat and rIFG also have direct connections with the right supramarginal gyrus and inferior parietal cortex, and with some premotor cortical areas, which may provide outputs for the OFClat and rIFG. Another key finding is that the ventromedial prefrontal cortex shares with the medial OFC especially strong outputs to the nucleus accumbens and olfactory tubercle, which comprise the ventral striatum, whereas the other regions have more widespread outputs to the striatum. Direct connections of the OFC and IFG were with especially the temporal pole part of the temporal lobe. The left IFG, which includes Broca\u2019s area, has direct connections with the left angular and supramarginal gyri.<\/jats:p>","DOI":"10.1093\/cercor\/bhaa160","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T03:22:52Z","timestamp":1590117772000},"page":"5830-5843","source":"Crossref","is-referenced-by-count":70,"title":["Connections of the Human Orbitofrontal Cortex and Inferior Frontal Gyrus"],"prefix":"10.1093","volume":"30","author":[{"given":"Chih-Chin","family":"Heather Hsu","sequence":"first","affiliation":[{"name":"Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 11221, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund T","family":"Rolls","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai 200433, China"},{"name":"Department of Computer Science, University of Warwick, 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