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Over the past decade, many studies have demonstrated the critical contributions of Notch signaling in neurogenesis, including that in the developing telencephalon. However, in vivo evidence for the role of Notch signaling in cortical development still remains limited partly due to the redundant functions of four mammalian Notch paralogues and embryonic lethality of the knockout mice. Here, we utilized the conditional deletion and in vivo gene manipulation of Rbpj, a transcription factor that mediates signaling by all four Notch receptors, to overcome these challenges and examined the specific roles of Rbpj in cortical development. We report severe structural abnormalities in the embryonic and postnatal cerebral cortex in Rbpj conditional knockout mice, which provide strong in vivo corroboration of previously reported functions of Notch signaling in neural development. Our results also provide evidence for a novel dual role of Rbpj in cell type-specific regulation of two key developmental events in the cerebral cortex: the maintenance of the undifferentiated state of neural progenitor cells, and the radial and tangential allocation of neurons, possibly through stage-dependent differential regulation of Ngn1.<\/jats:p>","DOI":"10.1093\/cercor\/bhaa206","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T07:26:19Z","timestamp":1594797979000},"page":"6444-6457","source":"Crossref","is-referenced-by-count":16,"title":["Dual Role of Rbpj in the Maintenance of Neural Progenitor Cells and Neuronal Migration in Cortical Development"],"prefix":"10.1093","volume":"30","author":[{"given":"Alexander I","family":"Son","sequence":"first","affiliation":[{"name":"Center for Neuroscience Research, Children\u2019s Research Institute, Children\u2019s National Hospital, Washington, DC 20010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Research, Children\u2019s Research Institute, Children\u2019s National Hospital, Washington, DC 20010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Research, Children\u2019s Research Institute, Children\u2019s National Hospital, Washington, DC 20010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Ishii","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Research, Children\u2019s Research Institute, Children\u2019s National Hospital, Washington, DC 20010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Research, Children\u2019s Research Institute, Children\u2019s National Hospital, Washington, DC 20010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazue","family":"Hashimoto-Torii","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Research, Children\u2019s Research Institute, Children\u2019s National Hospital, Washington, DC 20010, USA"},{"name":"Department of Pediatrics, Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20052, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Torii","sequence":"additional","affiliation":[{"name":"Center for Neuroscience Research, Children\u2019s Research Institute, Children\u2019s National Hospital, Washington, DC 20010, USA"},{"name":"Department of Pediatrics, Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20052, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"2020110401214446600_ref1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrn3024","article-title":"Not(ch) just development: notch signalling in the adult brain","volume":"12","author":"Ables","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"2020110401214446600_ref2","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1242\/dev.063610","article-title":"Notch signaling: simplicity in design, versatility in function","volume":"138","author":"Andersson","year":"2011","journal-title":"Development"},{"key":"2020110401214446600_ref3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: cell fate control and signal integration in 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