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To examine the relationships between cognitive function and the hippocampal subfields (HSs) in first-episode never-treated (FENT) schizophrenia patients, the HSs were segmented in 39 FENT patients and 30 healthy controls using a state-of the-art automated algorithm. We found no significant differences in any HSs between the patients and controls. However, multivariate regression analysis showed that the left cornu ammonis 1 (CA1), left hippocampal tail, left presubiculum, and right molecular layer contributed 40% to the variance of the PANSS negative symptom score. After adjusting for sex, age, education, and intracranial volume, the partial correlation analysis showed that the volumes of left CA1, CA3, CA4, molecular layer, granule cell layer and both left and right subiculum were negatively correlated with the MATRICS consensus cognitive battery (MCCB) Hopkins Verbal Learning Test (HVLT). Multiple regression analysis showed that the left CA1 and CA3 hippocampal abnormalities contributed 66% to the variance of the HVLT. Our results suggest no detectable HS deficits were found in FENT schizophrenia patients. However, the HSs may be involved in the symptoms and cognitive deficits of schizophrenia patients in the early phase of their illness.<\/jats:p>","DOI":"10.1093\/cercor\/bhaa208","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T19:19:39Z","timestamp":1595445579000},"page":"89-96","source":"Crossref","is-referenced-by-count":19,"title":["Cognitive Deficits and Clinical Symptoms with Hippocampal Subfields in First-Episode and Never-Treated Patients with Schizophrenia"],"prefix":"10.1093","volume":"31","author":[{"given":"Mei Hong","family":"Xiu","sequence":"first","affiliation":[{"name":"Beijing HuiLongGuan Hospital, Peking University HuiLongGuan Clinical Medical School, Beijing, 100096, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoE","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, First Hospital\/First Clinical Medical College of Shanxi Medical University, Taiyuan, 03000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing HuiLongGuan Hospital, Peking University HuiLongGuan Clinical Medical School, Beijing, 100096, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, T6G 2B7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R","family":"Kosten","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond Y","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Shi","sequence":"additional","affiliation":[{"name":"Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An Shi","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China"},{"name":"Department of Psychology, University of Chinese Academy of Sciences, Beijing, 100101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"2020121009133732600_ref1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/1073858410395147","article-title":"Hippocampal volume reduction in first-episode and chronic schizophrenia: a review and meta-analysis","volume":"18","author":"Adriano","year":"2012","journal-title":"Neuroscientist."},{"key":"2020121009133732600_ref2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00406-012-0350-7","article-title":"Association between fully automated MRI-based volumetry of different brain regions and neuropsychological test performance in patients with amnestic mild cognitive impairment and Alzheimer's disease","volume":"263","author":"Arlt","year":"2013","journal-title":"Eur Arch Psychiatry Clin Neurosci."},{"key":"2020121009133732600_ref3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3389\/fnhum.2013.00643","article-title":"Ten year neurocognitive trajectories in first-episode psychosis","volume":"7","author":"Barder","year":"2013","journal-title":"Front Hum Neurosci."},{"key":"2020121009133732600_ref4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13195-015-0147-9","article-title":"Verbal and non-verbal memory and hippocampal volumes in a memory clinic population","volume":"7","author":"Bonner-Jackson","year":"2015","journal-title":"Alzheimers Res Ther."},{"key":"2020121009133732600_ref5","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/mp.2016.262","article-title":"Hippocampal subfield volumes in mood disorders","volume":"22","author":"Cao","year":"2017","journal-title":"Mol Psychiatry."},{"key":"2020121009133732600_ref6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis. 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